The modern view of congenital cytomegalovirus infection: diagnosis, treatment and prevention

Abstract

A literature review of the works of foreign and domestic authors is devoted to modern approaches to the diagnosis, treatment and prevention of congenital cytomegalovirus infection (cCMV). The data of international consensuses are presented: «Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management» adopted by the cCMV group from the European society for pediatric infectious diseases (ESPID) in Leipzig, Germany in 2015, and «Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy» by an informal International Congenital Cytomegalovirus Recommendations Group (ICCRG), established in Brisbane, Australia in 2015 as part of the 5th International cCMV Conference about evidence-based treatment cCMV using antiviral drugs and immunotherapy. Particular attention is paid to the prevention of cCMV in both pregnant and newborns, as well as data from international studies on the cytomegalovirus vaccination.

Dendritic cells loaded with pp65 CMV mRNA nanoparticles as tool for generating CMV specific T cells

“…Это связано с ролью, которую ДК играют в организме не только в развитии иммунного ответа, но также в формировании и поддержании различных патологических процессов. ДК рассматриваются как важный инструмент в иммунотерапии инфекционных, онкологических, а также аутоиммунных и аллергических заболеваний [2,3].…”