The monitoring of gingival crevicular fluid volume during orthodontic treatment: a longitudinal randomized split-mouth study

Drummond, Stephanie; Canavarro, Cristiane; Perinetti, Giuseppe; Teles, Ricardo; Capelli, Jonas

doi:10.1093/ejo/cjq172

Cited by 35 publications

(54 citation statements)

References 24 publications

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“…Here, we investigated the effect of vibratory stimuli provided by an electric toothbrush on the level of IL-1b in GCF. The GCF volumes at each time point were not significantly different between the experimental and control sites, in agreement with the findings of Drummond et al, 20 who showed that GCF volume is not a reliable biomarker of tissue remodeling during orthodontic treatment. However, in this study, the levels of IL-1b in GCF increased after application of vibratory stimuli combined with orthodontic force, even though the GCF volumes did not vary significantly between control and experimental teeth at any time point.…”

Section: Discussionsupporting

confidence: 91%

Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Leethanakul

Suamphan

Jitpukdeebodintra

et al. 2015

The Angle Orthodontist

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Objectives: To investigate the effects of application of vibratory stimuli on interleukin (IL)-1b secretion during maxillary canine distalization. Materials and Methods: Split-mouth design study in 15 subjects (mean age, 22.9 years; range 19-25 years) whose bilateral maxillary first premolars were extracted with subsequent canine distalization. On the experimental side, light force (60 g) was applied to the canine for 3 months in combination with vibratory stimuli provided using an electric toothbrush 15 minutes a day for 2 months; only orthodontic force was applied to the contralateral control canine. Gingival crevicular fluid (GCF) was collected from the mesial and distal sides of each canine at each monthly appointment. IL-1b levels were analyzed using an enzyme-linked immunosorbent assay. Canine movement was measured monthly. Results: Overall, enhanced IL-1b secretion was observed at the pressure sites of experimental canines compared to control canines (mean, 0.64 6 0.33 pg/mL vs 0.10 6 0.11 pg/mL, respectively, P , .001). The accumulative amount of tooth movement was greater for the experimental canine than for the control canine (mean, 2.85 6 0.17 mm vs 1.77 6 0.11 mm, respectively, P , .001).Conclusions: This study demonstrates that, in combination with light orthodontic force, application of vibratory stimuli using an electric toothbrush enhanced the secretion of IL-1b in GCF and accelerated orthodontic tooth movement. (Angle Orthod. 2016;86:74-80.)

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Section: Discussionsupporting

confidence: 91%

Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Leethanakul

Suamphan

Jitpukdeebodintra

et al. 2015

The Angle Orthodontist

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“…The GCF volumes at each time point were of low statistical relevance in differences between the conventional and experimental groups, in agreement with the findings of Drummond et al (31) and Leethanakul et al (16) who showed that GCF volume is not a reliable biomarker of tissue remodeling during orthodontic treatment. Hence, it seems reasonable to continue using quantity of GCF only as a measurement necessary for estimating concentration of biomarkers into GCF and not for direct assumptions on orthodontic tooth movement.…”

Section: Discussionsupporting

confidence: 90%

Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Kalemaj¹,

Buti²,

Deregibus³

et al. 2017

J. Biomed

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Aims: The aims of the present study were to investigate rate of mandibular incisors alignment, levels of IL-1β and pain and discomfort during orthodontic alignment with the following: 1) conventional-ligating appliance (CLA); 2) self-ligating appliance (SLA); 3) self-ligating appliance combined to vibrational appliance (SLA-VA). Methods: This was a three-armed parallel group randomized clinical trial with allocation ratio 1:1:1. The main inclusion criteria were: full permanent dentition, age below 25 years, no missing teeth, first skeletal and molar class, non-extraction treatment, Little's Irregularity Index (LII) from 3mm to 6mm. The main outcomes were rate of mandibular incisors alignment, concentration of IL-1β and pain and discomfort. Measurements on models were performed at appliance placement (t0) and at monthly intervals for the first 3 months (T1, T2, T3), whereas IL-1β levels were measured at weekly intervals for the first 3 weeks (t1, t2, t3). Differences between groups for normally-distributed variables were initially estimated through Analyses of Variance (ANOVAs) tests, followed by Post-Hoc Scheffe analysis for pair wise comparisons. Results: Thirty-three patients were recruited and randomized with no lost to follow-up. During the first two months, faster alignment was observed for SLA (P=0.0491) and SLA-VA (P=0.0134) compared to CLA. At each time-point of measurement no differences were observed between SLA and SLA-VA. At t1 and t2 were found higher values of IL-1β for SLA-VA compared to SLA (P=0.0209, P=0.0352) and CLA (P=0.0018, P=0.0029), whereas at t3 the difference persisted only versus CLA (P=0.0304). No relevant differences in terms of pain and discomfort were observed between groups at any time point. Conclusions: Self-ligating appliances seem to perform better than conventional-ligating appliances in terms of timing of teeth leveling and alignment. Vibrational devices seem to enhance secretion of IL-1β but do not increase effectiveness of leveling and alignment with regard to treatment acceleration or pain reduction.

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“…Van Gastel et al [21], in their study, have examined periodontal parameters at the beginning of orthodontic treatment at and 3 month after the removal of brackets and reported that GCF volume increased at the removal of the brackets compared with baseline and that this volume is still higher than baseline 3 months later. Drummond et al [29] reported that GCF volume is not a reliable parameter reflecting orthodontic treatment-related tissue remodeling. In consistent with the studies indicating no change in GCF volume with orthodontic tooth movements [30, 31] we have found no significant change in GCF volume in all measurements prior to and at different stages of the treatment.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress Biomarkers in Patients with Fixed Orthodontic Appliances

Özcan

Ceylan

Özcan³

et al. 2014

Disease Markers

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Aim. The aim of this study was to examine the changes in the levels of interleukine-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), malondialdehyde (MDA), nitric oxide (NO), and 8-hydroxydeoxyguanosine (8-OHdG) in saliva and IL-1β, TNF-α, and NO in gingival crevicular fluid (GCF) samples of patients with fixed orthodontic appliances. Material and Method. The subject population consisted of 50 volunteers who were in need of orthodontic treatment with fixed orthodontic appliances. GCF and saliva samples were obtained from all individuals before treatment, at 1st month of treatment and at 6th month of treatment. Periodontal clinical parameters were measured. Samples were investigated to detect IL-1β, TNF-α, and 8-OHdG levels using ELISA method and NO and MDA levels using spectrophotometric method. Results. Since IL-1β level detected in GCF at the 6th month of orthodontic treatment is statistically significant according to baseline (P < 0.05), all other biochemical parameters detected both in saliva and in GCF did not show any significant change at any measurement periods. Conclusion. Orthodontic tooth movement and orthodontic materials used in orthodontic treatment do not lead to a change above the physiological limits that is suggestive of oxidative damage in both GCF and saliva.

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The monitoring of gingival crevicular fluid volume during orthodontic treatment: a longitudinal randomized split-mouth study

Cited by 35 publications

References 24 publications

Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Evaluation of Oxidative Stress Biomarkers in Patients with Fixed Orthodontic Appliances

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