The multi‐faceted role of allergen exposure to the local airway mucosa

Golebski, Korneliusz; Röschmann, Kristina; Toppila‐Salmi, Sanna; Hammad, Hamida; Lambrecht, Bart N.; Renkonen, Risto; Fokkens, W. J.; Drunen, Cornelis M. van

doi:10.1111/all.12080

Cited by 42 publications

(45 citation statements)

References 123 publications

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“…The epithelial cells are covered by a viscous mucosal lining rich in immune cells and soluble components, such as antioxidants, complement proteins, and surfactant proteins. 201,395,396 As the epithelium is more than a passive protective barrier, it recruits and activates more specialized immune cells and promotes inflammatory responses, 397 allergy is also discussed to be an epithelial barrier disease. 15,131,398−400 For example, nasal epithelium is clearly different between healthy and allergic subjects and only in allergic subjects the transport of Bet v 1 is caveolar-mediated.…”

Section: Epithelial Surface Interactionsmentioning

confidence: 99%

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Reinmuth-Selzle

Kampf

Lucas

et al. 2017

Environ. Sci. Technol.

237

177

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Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.

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Section: Epithelial Surface Interactionsmentioning

confidence: 99%

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Reinmuth-Selzle

Kampf

Lucas

et al. 2017

Environ. Sci. Technol.

237

177

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“…Children who exhibited at least one protease positive aeroallergen (Houst dust mite, mould mix, olea, grass mix) [14] sensitivity in the allergen skin prick test were included in the atopic asthma group, while those with negative allergen skin prick test results were included in the nonatopic asthma group. The ages of the children in the nonatopic group were similar to those in the atopic group.…”

Section: Study Populationmentioning

confidence: 99%

IL-5, IL-8 and MMP -9 levels in exhaled breath condensate of atopic and nonatopic asthmatic children

Türkeli

Yılmaz

Taneli

et al. 2015

Respiratory Medicine

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IL-5 levels, as a marker of eosinophilic inflammation, were demonstrated to be higher in the children with atopic asthma when compared to those with nonatopic asthma in EBC. The fact that no significant difference was apparent in the IL-8 levels between the groups suggests that it is the severity of the disease rather than the atopic state that plays an important role in IL-8 levels. Since no difference was recorded between the groups in terms of MMP-9 levels, lung damage in asthma sufferers seems to develop independent of atopia.

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“…Epithelial cells serve as barrier with the formation of tight junction including zona occludens (ZO), occludin and claudins [93]. As the epithelial barrier is breached by antigens, including microorganisms or allergens, through proteases, the epithelium starts secreting cytokines and chemokines to attract DCs to the site of contact or breach (Figure 3).…”

Section: Dcs Interaction With Airway Epithelial Cellsmentioning

confidence: 99%

Clinical view on the importance of dendritic cells in asthma

Gaurav

Agrawal

2013

Expert Review of Clinical Immunology

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Summary Allergic asthma is characterized by airway hyperresponsiveness and inflammation and may lead to airway remodeling in uncontrolled cases. Genetic predisposition to an atopic phenotype plays a major component in the pathophysiology of asthma. However, with tremendous role of epigenetic factors and environmental stimuli in precipitating an immune response, the underlying pathophysiological mechanisms are complicated. Dendritic cells are principal antigen presenting cells and initiators of the immune response in allergic asthma. Their phenotype, guided by multiple factors may dictate the immune reaction to an allergic or tolerogenic response. Involvement of the local cytokine milieu, microbiome and interplay between immune cells add dimension to the fate of immune response. In addition to allergen exposure, these factors modulate DC phenotype and function. In this article, integration of many factors and pathways associated with the recruitment and activation of DCs in the pathophysiology of allergic asthma is presented in a clinical and translational manner.

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The multi‐faceted role of allergen exposure to the local airway mucosa

Abstract: To cite this article: Golebski K, R€ oschmann KIL, Toppila-Salmi S, Hammad H, Lambrecht BN, Renkonen R, Fokkens WJ, van Drunen CM. The multi-faceted role of allergen exposure to the local airway mucosa. Allergy 2013; 68: 152-160.

Cited by 42 publications

References 123 publications

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

IL-5, IL-8 and MMP -9 levels in exhaled breath condensate of atopic and nonatopic asthmatic children

Clinical view on the importance of dendritic cells in asthma

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