The mycotoxins deoxynivalenol and nivalenol show in vivo synergism on jejunum enterocytes apoptosis

Cheat, Sophal; Pinton, Philippe; Cossalter, Anne Marie; Cognié, Juliette; Vilariño, M.; Callu, P.; Raymond‐Letron, Isabelle; Oswald, Isabelle P.; Kolf‐Clauw, Martine

doi:10.1016/j.fct.2015.11.019

Cited by 31 publications

(12 citation statements)

References 55 publications

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“…These results were consistent with the findings of Cheat et al. (), who reported that receiving a naturally contaminated feed with DON (3.5 mg/kg feed) for 28 days did not affect weight gain and feed intake in piglets. Further, 5‐week‐old piglets fed a naturally contaminated diet with DON (1.5 mg/kg feed) for 28 days showed no difference in weight gain when compared with pigs fed the control diet (Gerez et al., ).…”

Section: Discussionsupporting

confidence: 93%

Short‐term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion

Su³

et al. 2018

Animal Science Journal

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The mycotoxin deoxynivalenol (DON) generally exists in cereals and affects human and animal health. The aim of this study is to analyze the impacts of DON in naturally contaminated feed on piglet growth performance and intestinal hormone secretion in the short term. We randomly divided 5-week-old piglets into four groups: Control, DON 1,000, DON 2,000 and DON 3,000 groups. Piglets received a feed naturally contaminated with DON (approximately 400, 1,000, 2,000 or 3,000 μg/kg) for 21 days. Body weight showed no significant difference following exposure to DON. The balance of anti-oxidation and oxidation was disrupted by DON after 21 days. The concentration of tumor necrosis factor-alpha (TNF-α) and cyclooxgenase-2 (COX-2) significantly increased (p < .001) in all DON-treated groups. Gut anorexigenic hormone secretion of peptide YY (PYY) and cholecystokinin (CCK) had a time- and dose-dependent relationship with DON exposure; however, there was no effect on orexigenic hormone ghrelin secretion. Changes of histomorphology in the jejunum were observed in DON-treated groups, including villi flattening and fusion, and apical necrosis of villi. These results indicated that DON could suppress piglet growth performance and alter gut hormone secretion in the short term.

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Section: Discussionsupporting

confidence: 93%

Short‐term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion

Su³

et al. 2018

Animal Science Journal

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“…Luongo et al reported that NIV induced necrosis in murine dendritic cells, but necrosis was not observed in DON-treated cells 25) . On the other hand, the number of reports regarding synergisms between these two toxins is growing [26][27][28][29][30][31] . These reports reinforce my idea that if two toxins exert their toxicities through the same mechanism, synergism of toxicities is not considered to be observed.…”

Section: Other Groups' Resultsmentioning

confidence: 99%

Deoxynivalenol and Nivalenol Toxicities in Cultured Cells: a Review of Comparative Studies

Nagashima

2018

Food Safety

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The in vitro studies of the toxicities of trichothecene mycotoxins deoxynivalenol (DON) and nivalenol (NIV) including cell proliferation, cytokine secretion, and the involvement of heat shock protein 90 (Hsp90) in their toxicities were reviewed. Trichothecene mycotoxins are extremely toxic to leukocytes and leukopenia is one of the leading signs of trichothecene toxicosis, implying that trichothecenes hinder cell proliferation. Both toxins retarded proliferation of all four cell lines tested. NIV was more potent than DON in human promyelocytic leukemia cell line HL60, human lymphoblastic leukemia cell line MOLT-4, and rat aortic myoblast cell line A-10. In contrast, both toxins exhibited almost the same potencies in human hepatoblastoma cell line HepG2. While exposure to 0.3 μg/mL DON greatly induced the secretion of anti-hematopoietic cytokines CCL3 and CCL4, treatment with NIV decreased the secretion of these cytokines in HL60 cells, indicating that the toxicity mechanisms of these mycotoxins differ. Because molecular chaperone Hsp90 occupies a pivotal position in a wide range of pathological processes, the effects of an Hsp90-specific inhibitor radicicol on cytokine secretions were investigated. Radicicol counteracted the effect of DON on cytokine secretion, indicating that Hsp90 plays a crucial role in DON-induced cytokine secretion in HL60 cells. Conversely, the results of co-treatment with NIV and radicicol indicate that radicicol does not mitigate the effect of NIV. Regarding CCL3 and CCL4 secretions, DON and NIV have Hsp90-related and -unrelated mechanisms of toxicities, respectively. Taken together the results suggest that, although these toxins share similar chemical structure, there are differences in their toxic mechanisms.

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“…It has nephrotoxic, hepatotoxic, teratogenic, and immunotoxic properties. Previous studies suggest that ZEN, OTA, and other mycotoxins may coexist in a single product and hence could synergize the toxicity (Yan et al, 2015;Cheat et al, 2016). To guarantee food safety, the European Union has established the provisional maximum tolerable levels of 5 and 100 μg/kg in unprocessed cereals for OTA and ZEN, respectively (Yang et al, 2012;Majdinasab et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Dual flow immunochromatographic assay for rapid and simultaneous quantitative detection of ochratoxin A and zearalenone in corn, wheat, and feed samples

Zhang

Fang³

et al. 2018

J. Zhejiang Univ. Sci. B

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A one-step dual flow immunochromatographic assay (DICGA), based on a competitive format, was developed for simultaneous quantification of ochratoxin A (OTA) and zearalenone (ZEN) in corn, wheat, and feed samples. The limit of detection for OTA was 0.32 ng/ml with a detection range of 0.53-12.16 ng/ml, while for ZEN it was 0.58 ng/ml with a detection range of 1.06-39.72 ng/ml. The recovery rates in corn, wheat, and feed samples ranged from 77.3% to 106.3% with the coefficient of variation lower than 15%. Naturally contaminated corn, wheat, and feed samples were analyzed using both DICGA and liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the correlation between the two methods was evaluated using a regression analysis. The DICGA method shows great potential for simple, rapid, sensitive, and cost-effective quantitative detection of OTA and ZEN in food safety control.

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The mycotoxins deoxynivalenol and nivalenol show in vivo synergism on jejunum enterocytes apoptosis

Cited by 31 publications

References 55 publications

Short‐term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion

Short‐term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion

Deoxynivalenol and Nivalenol Toxicities in Cultured Cells: a Review of Comparative Studies

Dual flow immunochromatographic assay for rapid and simultaneous quantitative detection of ochratoxin A and zearalenone in corn, wheat, and feed samples

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