The pathology and management of endocervical glandular neoplasia

El‐Ghobashy, Alaa; Shaaban, Abeer M.; Herod, Jonathan; Herrington, C. Simon

doi:10.1111/j.1525-1438.2005.00113.x

Cited by 14 publications

(8 citation statements)

References 74 publications

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“…While the sequence of events leading to malignant transformation of receptive primary cells following infection by oncogenic viruses has been studied in great detail (22) , very little is known about the effect of nononcogenic viral infection on transformed cells. To gain insight to the biology of nononcogenic virus-transformed cell system interactions, we activated the stress responsive mechanisms of immortal adenocarcinoma cells (HeLa) using infection with influenza B virus and compared the resulting morphologic, phenotypic, and divisional properties of surviving infected hosts to those of their uninfected precursors and normal primary endocervical adenoepithelial and metaplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Comparing normal primary endocervical adenoepithelial cells to uninfected and influenza B virus infected human cervical adenocarcinoma HeLa cells

Sioutopoulou

Plakokefalos

Anifandis

et al. 2006

Int J Gynecol Cancer

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Human adenocarcinoma HeLa cells surviving infection with low (10(-9) units), medium (10(-6) units), and high (10(-2) units) influenza B titers were compared to their uninfected precursors and to normal endocervical adenoepithelial and metaplastic cells using Papanikolaou-staining method and immunocytochemistry. Normal primary endocervical and infected HeLa cells surviving infection shared similar morphologic, phenotypic, and divisional patterns that differed drastically from those of uninfected HeLa cells. The number of infected hosts surviving 6-7 days of viral exposure did not change during 3-week follow-up period, and their cyclin E levels suggested that they had been arrested to the G1 phase of the cell cycle by viral stress. Our findings suggest that in addition to apoptosis, nononcogenic viral stress activated the expression of endocervical metaplastic-like motifs in surviving hosts. A mechanism of cell response to nononcogenic viral stress was proposed to explain these findings. We conclude that nononcogenic respiratory viruses specifically target and eliminate abnormal cells ectopically overexpressing appropriate receptors and may complement current treatments of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Comparing normal primary endocervical adenoepithelial cells to uninfected and influenza B virus infected human cervical adenocarcinoma HeLa cells

Sioutopoulou

Plakokefalos

Anifandis

et al. 2006

Int J Gynecol Cancer

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“…A rise in the proportion of patients with adenocarcinoma of the cervix [29] has been described. Use of estrogen therapy was associated with a RR of 2.7 (95% CI 1.1-6.8) for adenocarcinoma [30] but there is currently no study on recurrence risk in survivors of adenocarcinoma of the cervix.…”

Section: Cervical Cancermentioning

confidence: 98%

Managing menopausal symptoms after gynecological cancer

Michaelson‐Cohen¹,

Beller²

2009

Current Opinion in Oncology

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There is no evidence showing hormones negatively influence survival after treatment for epithelial ovarian, squamous cervical or vulvar cancer. Their use can be considered in symptomatic patients with endometrial cancer, after weighing the benefits against the risk of recurrence. Gynecologic cancer survivors suffering from menopausal symptoms should be supported by advice about the alternatives to hormonal replacement therapy and by giving them nonbiased information on the present knowledge on the effects of hormonal use in women with a previous cancer. It is reasonable to prescribe hormonal replacement therapy to symptomatic, well informed patients.

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“…Microscopically, the evolution of the lesion is characterized by the differentiation of epithelial cells that proliferate and invade the epithelial tissue. Progression is described in terms of increase in the degree of dysplasia (mild, moderate, severe) and carcinoma in situ (El-Ghobashy et al, 2005). Early lesions are now considered manifestations of HPV infection, which are characterized by the presence of nuclear changes and cell proliferation of the epithelium.…”

Section: Introductionmentioning

confidence: 99%