The potential of enzyme entrapment in konjac cold-melting gel beads

Preparation, composition analysis and antioxidant activities of konjac oligo-glucomannan

“…KG cannot be hydrolyzed by digestive enzymes in the human upper gastrointestinal tract and is therefore regarded as an indigestible dietary fiber, which has been demonstrated to be effective in weight reduction, regulation of lipid metabolism, improvement of glucose metabolism and cholesterol reduction (Chua, Baldwin, Hocking, & Chan, 2010;Xiong et al, 2009;Zhou et al, 2013). Konjac is recognized as a safe material according to the FDA (Pérols, Piffaut, Scher, Ramet, & Poncelet, 1997), and it is also used as a functional healthcare drug for diabetics and adiposis in China.…”

Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery

“…KGM is a high-molecular weight, watersoluble, non-ionic, natural polysaccharide isolated from the tubers of the amorphophallus konjac plants and the main crop in mountainous areas of China (Yu, Huang, & Xiao, 2006). It is mainly composed of a high-molecular weight glucomannan in which mannose and glucose units in a ratio of 1.6:1 are connected by b-(1,4) linkages (PéCrols et al,1997). Due to its biodegradability, biocompatibility, not degradable by digestive enzymes in upper gastrointestinal tract but degradable by b-mannanase (He, Zhang, & Huang, 2001) or other b-glycosidases abundant in colon, KGM shows promise in controlled release systems and serves as biomedical materials (Gonzalez et al, 2004;Liu, Hu, & Zhuo, 2004;Liu, Shao, & Lü, 2006;Wen, Cao, Yin, Wang, & Zhao, 2009).…”

Characteristics of konjac glucomannan and poly(acrylic acid) blend films for controlled drug release

“…9,10 Moreover, characters of low cost, excellent film-forming ability and good biocompatibility, biodegradability, and hydrophilicity entitle KGM to be a novel polymer material applied in the fields of coating, food preservative, 11 and enzyme entrapment. 12 In recent years, by modifying with physicochemical methods, KGM shows promise in controlled release systems and serves as biomedical materials. [12][13][14][15] Except for the natural polysaccharide mentioned earlier, several synthetic polymers including poly-(acrylic acid) (PAA), poly(vinyl alcohol), and polymethacrylate have been described as bioadhesive polymers and used in controlled release systems.…”

“…12 In recent years, by modifying with physicochemical methods, KGM shows promise in controlled release systems and serves as biomedical materials. [12][13][14][15] Except for the natural polysaccharide mentioned earlier, several synthetic polymers including poly-(acrylic acid) (PAA), poly(vinyl alcohol), and polymethacrylate have been described as bioadhesive polymers and used in controlled release systems. 16 -18 Of these, PAA exhibits strongest mucosal adhesion and wide applications as biomedical material.…”