The potential value of the protein S-100B level as a criterion for hyperbaric oxygen treatment and prognostic marker in carbon monoxide poisoned patients

Brvar, Miran; Možina, Hugon; Osredkar, Joško; Možina, Martin; Brucan, A; Bunc, Matjaž

doi:10.1016/s0300-9572(02)00289-7

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…Boettiger et al presented similar results in 66 patients after cardiac arrest [121]. Moreover, Brvar et al in a pilot study showed that carbon monoxide poisoning appears to be associated with elevated S-100B levels and used S-100B values to select patients for hyperbaric oxygen therapy [122,123].…”

Section: Stroke-cerebral Hypoxiamentioning

confidence: 87%

Serum S-100B Protein as A Biochemical Marker of Brain Injury: A Review of Current Concepts

Korfias

Stranjalis²,

Papadimitriou³

et al. 2006

CMC

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S-100 protein, described initially by Moore, constitutes a large family of at least 20 proteins with calcium binding ability. It is found as homo- or hetero-dimers of two different subunits (A and B). Types S-100AB and S-100BB are described as S-100B protein and are shown to be highly specific for nervous tissue. It is present in the cytosol of glial and Schwann cells, and also in adipocytes and chondrocytes, although in very low concentrations in the latter two. The role of protein S-100B is not yet fully understood. It is suggested that it has intracellular and extracellular neurotropic as well as neurotoxic function. At nanomolar levels, S-100B stimulates neurite outgrowth and enhances survival of neurons. However, at micromolar levels it stimulates the expression of inflammatory cytokines and induces apoptosis. Recently, serum S-100B protein has been proved to be an attractive surrogate marker of primary severe brain injury and secondary insults. It can be measured in the arterial and venous serum; it is not affected by haemolysis and remains stable for several hours without the need for immediate analysis. Its short half-life makes measurements crucial in the emergency and intensive care settings. This review summarises published findings on S-100B regarding its role as a serum biochemical marker of brain injury, i.e., after severe, moderate or mild neuro-trauma, subarachnoid haemorrhage, thrombo-embolic stroke, cerebral ischaemia and brain tumours, as well as extracranial trauma, neurodegenerative and psychiatric disorders.

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Section: Stroke-cerebral Hypoxiamentioning

confidence: 87%

Serum S-100B Protein as A Biochemical Marker of Brain Injury: A Review of Current Concepts

Korfias

Stranjalis²,

Papadimitriou³

et al. 2006

CMC

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“…Because the level of consciousness is one of the major parameters for the treatment of CO-poisoned humans, the results of this study should encourage the prospective and controlled studies of prognostic values of S100B in CO-poisoned patients. S100B could be used as a biochemical marker, a prognostic parameter, and an additional criterion for the treatment of CO-poisoned patients (10,11).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, neurobiochemical markers of brain damage, such as S100B, have gained increasing interest in clinical research as useful biochemical markers of brain damage in circulatory arrest (4,5), stroke (6), intracranial hemorrhage (7), and traumatic head injury (5,8,9). S100B, a structural protein of astroglial cells, has been shown to be a possible marker of CO poisoning in humans (10,11), but its prognostic value has not yet been demonstrated. The aim of the study was to assess the possible use of S100B as a biochemical marker and prognostic parameter in acute carbon monoxide poisoning.…”

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confidence: 99%

Prognostic value of S100B protein in carbon monoxide-poisoned rats

Brvar

Možina²,

Osredkar³

et al. 2004

Critical Care Medicine

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“…Fetal monitoring may be helpful to detect fetal compromise in the COpoisoned pregnant patient [171]. Most recently, the role of biochemical markers of brain damage (neuron-specific enolase, S-100 beta) after CO poisoning has been investigated [172][173][174]. In one series of 38 CO-poisoned patients, S-100 beta levels correlated well with severity of illness [173].…”

Section: Other Diagnostic Testingmentioning

confidence: 99%