The Preclinical and Clinical Effects of Herbal Product Containing Rosa mutiflora Roots Extracts as a Main Component on the Hair Growth Promotion

Abstract

: In this study, to develop hair growth agents using natural products which has excellent ability to promote hair growth effect and fewer side effect, animal experiment and clinical trials was performed to evaluate hair growth promotion effect of herbal product containing Rosa multiflora roots extracts as a main component (RMHP). 4-week-old male C57BL/6 mice were removed the dorsal hair using thioglycolate, and applied 15% EtOH solution as a negative control, 5% minoxidil as a positive control and RMHP to dorsal skin. In the results of macroscopy and photo-interpretation, RMHP group recorded 100% (+++++) of hair growth was proved to significantly stimulate hair growth against 80% (++++) negative control group. 37 patients were treated with RMHP and evaluated the therapeutic effect at 16 weeks. Hair density was significantly increased at 16 weeks after applying RMHP (125.0 ± 4.9 FU/㎠) compared to before treatment (104.3 ± 4.7 FU/㎠, p < 0.05), and hair thickness were also significantly increased (0.066 ± 0.003 ㎜) than before treatment (0.055 ± 0.002 ㎜, p < 0.05). The result of clinical photo-interpretation using 7-point rating scale assessment, after 16 weeks clinical symptoms were evaluated to significantly improve with 1.23 ± 0.05 (p < 0.05). Therefore, the results of this study were observed that RMHP have hair loss prevention effect and hair growth promotion effect to hair loss patients.

Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity

“…erefore, our study sought to investigate the hair-growth- Evidence-Based Complementary and Alternative Medicine promoting properties of NS extract through in vitro experiments using hDPCs and in vivo experiments using C57BL/6 mice. According to previous studies, antioxidant substances suppress hair loss-promoting cytokine activity, thereby promoting hair growth [34,36]. A study by Kim et al [37] reported that the average flavonoid content of 40 native plants was 70 mg NE/g.…”

“…In addition to genetic factors, alopecia is caused by excessive stress, malnutrition, hormonal imbalances, and aging and is accompanied by a reduction in hair follicle size and anagen follicles [28][29][30]. Currently, many studies have been conducted using natural materials, such as herbal medicines and biopharmaceuticals, to identify therapeutic compounds capable of promoting hair growth and reducing hair loss [31][32][33][34]. While the activity of glutathione and SOD etc.…”

“…While the activity of glutathione and SOD etc. in the blood of hair loss patients has been found to be significantly low in hair loss patients, the levels of thiobarbituric acid reactive substances (TBARS) are significantly higher than those of patients without hair loss [ 34 ]. The resulting oxidative stress has been reported as the likely cause of hair loss [ 19 ].…”

“…According to previous studies, antioxidant substances suppress hair loss-promoting cytokine activity, thereby promoting hair growth [ 34 , 36 ]. A study by Kim et al [ 37 ] reported that the average flavonoid content of 40 native plants was 70 mg NE/g.…”

Platycarya strobilacea S. et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-promoting Effects in Male C57BL/6 Mice

“…Because the current alopecia treatments, minoxidil and finasteride, have temporary effects and cause numerous side effects, there has been a growing interest in natural materials that encourage hair growth and have no side effects. Previous research indicates that high-antioxidant materials such as fermented Liriope platyphylla , green tea, onion extract, and wild rose root extract, have high anti-oxidant activities and high hair growth-promoting effects ( 22 – 25 ), with suppression of alopecia-promoting cytokine activities. Researchers are actively seeking natural materials that promote hair growth ( 26 ).…”