The prevalence of Peyronie's disease in diabetic patients -2018- Yazd

Askari, Maryam; Mirjalili, Seyed Ali Mohamad; Bozorg, Mina; Azizi, Rasoul; Namiranian, Nasim

doi:10.1016/j.dsx.2018.11.039

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…Also, the questionnaire was prepared by combining and integrating similar questionnaires used in previous major prevalence studies. 19 Diabetic patients with erectile dysfunction 20.3 Chung et al 2018 18 Web based-general population 19 Dibenedetti et al 2011 16 General population 0.5e13.1 Stuntz et al 2016 17 General population 0.7e11 Mulhall et al 2004 15 Men screened for prostate cancer 8.9 El-Sakka 2006 6 Patients with erectile dysfunction 7.9 La Pera et al 2001 8 General population 7.1 Askari et al 2019 22 Diabetic patients 3.8 Rhoden et al 2001 20 Men older than 50 years undergoing prostate cancer screening 3.7 Schwarzer et al 2001 3 Sommer et al 2002 14 General population 3.2…”

Section: Discussionmentioning

confidence: 99%

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

et al. 2020

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Introduction: Peyronie's disease (PD) prevalence varies between 0.39% and 20% and studies on PD prevalence are limited. Aim: This study aims to determine the prevalence of PD in males aged 30 years in Turkey and to evaluate etiological factors associated with it. Methods: The study was conducted in 12 regions of Turkey according to the Eurostat Nomenclature of Territorial Units for Statistics 1 classification and included 1,208 patients. Survey questionnaires including questions about demographic features and basic health status as well as about diagnosis and etiology of PD were put forth to the volunteers who agreed to participate in the study. Diagnosis of probable PD was established by evaluating the questionnaires. Patients with a diagnosis of congenital penile curvature were excluded from the group with PD. Chi-square test, Fisher's exact test, and Mann-Whitney U test were used. Main Outcome Measure: The primary outcome analyzed in this article was the prevalence rate of PD in Turkey and the associated comorbidities. Results: The prevalence of PD was determined as 5.3%. The rates of participants with PD were found to be the highest in the 50e59 years group (27%) and in the NorthEast Region (20%). Compared with participants without PD, participants with PD were older (median: 52 interquartile range [41e64] vs 45 [37e55]; P < .001) and the rates of smokers (73% vs 60.9%; P ¼ .036) and those having diabetes mellitus (17.5% vs 9.2%; P ¼ .045), hypertension (14.3% vs 6.9%; P ¼ .041), and heart failure were higher (7.9% vs 2.5%; P ¼ .027). Male with PD symptoms preferred their partners on top during sexual intercourse (15.2% vs 34.1%; P < .001). This is the first study to evaluate premature ejaculation prevalence and related comorbidities with face-to-face interviews. Conclusion: The prevalence of PD was 5.3% in Turkey. Besides advanced age, smoking, position of sexual intercourse, and presence of comorbidities especially diabetes mellitus, hypertension, and heart failure were the factors associated with PD prevalence.

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Section: Discussionmentioning

confidence: 99%

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

et al. 2020

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“…Estimating epidemiological data on PD can be challenging, in part due to patients’ reluctance to report their symptoms. Although there are three studies that have reported on prevalence of PD in the general U.S. population [ 5 , 7 , 9 ], there is a paucity of incidence reports. Additionally, previous studies were conducted in different subpopulations, or in single communities or cohorts that do not represent the general demographic of adult men in the U.S.…”

Section: Discussionmentioning

confidence: 99%

“…This conclusion is supported by our results, although the calculated prevalence in the Southern U.S. (0.083%) is lower than what was reported by Stuntz. While the exact association between geographic region and PD diagnosis is unclear, conditions such as hypertension, obesity, and diabetes, which have been previously linked to increased risk of PD [ 9 – 11 , 13 ], are more prevalent in the Southern U.S [ 14 ]. Further work, however, is needed to strengthen this conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies report similar prevalence rates, and estimated incidence rate of 22.4–25.6 cases per 100,000 men, with the highest found in men 50 to 59 years old [ 5 – 8 ]. Some studies have observed an increased incidence of PD in individuals with certain conditions, thus presenting a possible link between these diseases and developing PD [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Regional variation in the incidence and prevalence of Peyronie’s disease in the United States—results from an encounters and claims database

et al. 2020

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In recent years there have been more studies dedicated to Peyronie’s disease (PD). However, prevalence and incidence are likely underestimated, with limited information on regional variation in the rate of diagnosis. In this study, we sought to estimate age and regional variation of the annual incidence and prevalence of PD in the United States. We reviewed data from the IBM MarketScan™ Claims and Encounters database between 2008–2017 for men ≥18 years. Inclusion required ≥1 medical claim with PD, identified by ICD-9 and ICD-10 codes or ≥1 claim for intralesional injection for PD, identified by Current Procedure Terminology (CPT) code. Overall average annual incidence was estimated at 20.9 cases per 100 000, with the highest rate of 41.6 cases per 100 000 observed in men 55–64 years (RR=8.2; p<0.0001). Geographically, the highest incidence rate was observed in the South (23.9 cases per 100,000 men; RR=1.30; p<0.0001). Across all ages, overall prevalence of PD showed a general upward trend, from 0.052% in 2008 to 0.096% in 2017. Our findings suggest men in the southern U.S. are diagnosed more with PD compared to other regions. Identification of associated factors may allow for a more proactive approach to diagnosis and management.

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“…Several studies have suggested a relationship between Peyronie's disease and diabetes (Table 1, Peyronie's disease) 14,17,18 . In addition, a 2019 Iranian study reported a prevalence of Peyronie's disease of 3.8% among 317 men with type 2 diabetes 19 . In a retrospective study of 1622 men presenting to a urology health centre, the presence of type 2 diabetes (n = 387; 24%) was significantly associated with Peyronie's disease ( P = .005); logistic regression analysis identified a significant association between glycated HbA 1c > 69 mmol/mol (8.5%; eg poorly controlled) and Peyronie's disease (odds ratio [OR] = 1.6 [95% CI, 1.1‐2.5]; P = .025) 20 .…”

Section: Introductionmentioning

confidence: 99%

Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes

Gelbard

Rosenbloom

2020

Endocrino Diabet & Metabol

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Introduction Fibrosis is characterized by dysregulation and accumulation of extracellular matrix. Peyronie's disease and Dupuytren disease are fibroproliferative disorders of the tunica albuginea of the penis and fascia of the hand, respectively. Chronic hyperglycaemia due to diabetes mellitus can also lead to tissue injury and fibrosis. A meta‐analysis has shown a relationship between Dupuytren disease and diabetes (overall odds ratio, 3.1; 95% confidence interval, 2.7‐3.5). This review explores commonalities in the pathogenesis of Peyronie's disease, Dupuytren disease and diabetes. Methods A search of the PubMed database was conducted using the search terms “diabetes” AND “Peyronie's disease”; and “diabetes” AND “Dupuytren.” Results Genome‐wide association and gene expression studies conducted with tissue from people with Peyronie's disease or Dupuytren disease identified signalling pathways associated with wingless‐type mammary‐tumour virus integration site signalling, extracellular matrix modulation and inflammation. Biochemical studies confirmed the importance of these pathways in the pathogenesis of fibrosis with Peyronie's disease and Dupuytren disease. Dysregulation of matrix metalloproteinase activity associated with extracellular matrix breakdown was implicated in fibroproliferative complications of diabetes and in the aetiology of Peyronie's disease and Dupuytren disease. A notable percentage of people with diabetes have comorbid Peyronie's disease and/or Dupuytren disease. Conclusions Studies have not been performed to identify fibroproliferative pathways that all 3 conditions might have in common, but data suggest that common pathways are involved in the fibroproliferative processes of Peyronie's disease, Dupuytren disease, and diabetes.

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The prevalence of Peyronie's disease in diabetic patients -2018- Yazd

Cited by 10 publications

References 10 publications

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

Regional variation in the incidence and prevalence of Peyronie’s disease in the United States—results from an encounters and claims database

Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes

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