The protective effect of resveratrol on diazinon‐induced oxidative stress and glucose hemostasis disorder in rats' liver

Abstract

This study was intended to assess the possible protective effect of resveratrol (Res) against oxidative stress and glucose hemostasis disorder in rats exposed to diazinon (DZN) for 4 weeks. Totally 25 Sprague-Dawley rats were divided randomly into five groups: Control (orally received corn oil), DZN group (orally received 70 mg/kg/day), and Res groups (received DZN 70 mg/kg/day plus Res doses of 5, 10, and 20 mg/kg bodyweight/-day), respectively. DZN significantly inhibited serum acetylcholinesterase enzyme (Ach E), serum and liver catalase, glutathione peroxidase activities, also total antioxidant capacities. On the other hand, DZN increased serum and liver malondialdehyde. DZN significantly increased Forkhead box protein O1 (Foxo1) expression and decreased phosphatase and tensin homolog (PTEN) and sirtuin 1 (Sirt-1) expression. DZN impaired glucose hemostasis. Instead, Res treatment significantly reversed status of oxidative stress and antioxidant enzymes activities induced by DZN. Also, Res improved glucose hemostasis. Res increased PTEN and Sirt-1 expression and reduced Foxo1 expression. Res administration ameliorated liver histopathological changes induced by DZN. These data confirmed that DZN significantly enhances oxidative stress and impairs glucose hemostasis. While Res showed a protective effect against the toxicity induced by DZN in rats.

The role of oxidative stress in ovarian aging: a review

“…It can maintain the balance between cell proliferation and apoptosis, and reduce nuclear chromatin clumping in ovarian granulosa cells [245]. Resveratrol (Res) is a natural plant-derived phenol with excellent antioxidant activity [246]. Res has been found to attenuate the damage caused by cyclophosphamide on ovarian function, including reducing OS damage, inhibiting apoptosis and promoting ovarian stem cell repair [18].…”

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin

“…As noted throughout this manuscript, oxidative stress has been proposed to play a pathological role in DZN poisoning and the liver is an important target organ of this pesticide. In this way, natural antioxidants compounds from different sources have been studied as protective agents of the DZN-induced liver toxicity [42] , [46] , [5] , [11] . The present study demonstrated that THC prevented HepG2 cell death induced by DZN.…”

Review of the Potential Therapeutic Effects and Molecular Mechanisms of Resveratrol on Endometriosis

“…Resveratrol treatment can reverse the experimental induced oxidative stress condition and upregulate SIRT1 expression. 111 Taguchi et al reported that resveratrol ameliorates local inflammation in endometriosis by suppressing TNF-α-induced IL-8 release in a dose-dependent manner via the SIRT1 pathway. 112 …”

“… 127 In diazinon (DZN)-induced oxidative stress rat models, Mehri et a reported that DZN inhibits serum acetylcholinesterase (AChE) as well as serum and liver CAT, GSH-Px, and total antioxidant abilities, and they also demonstrated that resveratrol reverses the oxidative stress conditions, improves the activity of antioxidant enzymes, and lower MDA level in the serum and liver. 111 …”