The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose

Piconi, Ludovica; Corgnali, Maddalena; Ros, Roberto Da; Assaloni, Roberta; Piliego, T.; Ceriello, Antonio

doi:10.1016/j.jdiacomp.2007.03.004

Cited by 37 publications

(17 citation statements)

References 25 publications

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“…All methods confirm that IHG is more effective than constant high glucose in producing SC apoptosis. These data suggests that glucose variations may be more deleterious for the cells than stable high glucose, which were consistent with previous observations in human umbilical endothelial cells (Piconi et al, 2008;Risso et al, 2001), mesangial cells (Takeuchi et al, 1995), and tubulointerstitial cells (Jones et al, 1999). We also characterized the molecular pathways by which IHG triggered SCs apoptosis and found that IHG significantly up-regulated the Bax expression, but down-regulated the BcL-2 expression in SCs.…”

Section: Discussionsupporting

confidence: 91%

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Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

Sun

Xue

et al. 2012

Life Sciences

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Section: Discussionsupporting

confidence: 91%

“…It is now recognized that glucose fluctuation may be more dangerous for diabetes than constant high glucose (Piconi et al, 2008). However, the mechanism underlying the action of IHG is a mystery.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

Sun

Xue

et al. 2012

Life Sciences

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“…[44] Rosuvastatin was shown to have a regulatory effect on the NOS enzyme, and this effect was reported to be independent of the lipid-decreasing effect. [45] Similarly, we observed that when rosuvastatin was given singly in our study, NO levels were significantly lower compared to the control group only in the cerebellum; in the brainstem and cerebral cortex, they were similar to the control group. In spite of the fact that in noise exposure, rosuvastatin treatment does not significantly change the NO levels in the brainstem and cerebellum, NO levels were found to be lower compared to the group only exposed to noise.…”

Section: Discussionsupporting

confidence: 76%

Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

et al. 2014

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The problem of noise has recently gained more attention as it has become an integral part of our daily lives. However, its influence has yet to be fully elucidated. Other than being an unpleasant stimulus, noise may cause health disorders through annoyance and stress, including oxidative stress. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, may possess antioxidant properties. Based on rat models, our project investigates the effect of rosuvastatin on noise-induced oxidative stress in the brain tissue. Thirty-two male Wistar albino rats were used. The rats were divided into four groups: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage, and control. After the data had been collected, oxidant and antioxidant parameters were analyzed in the cerebral cortex, brain stem, and cerebellum. Results indicated that superoxide dismutase values were significantly decreased in the cerebral cortex, while malondialdehyde values in the brainstem and cerebellum were significantly increased in the group with only noise exposure. Superoxide dismutase values in the brainstem were significantly increased, but nitric oxide values in the cerebellum and brainstem and malondialdehyde values in the cerebellum and cerebral cortex were significantly decreased in the group where only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased superoxide dismutase values in the cerebral cortex and brainstem, but significantly reduced malondialdehyde values in the brain stem. Consequently, our data show that brain tissue was affected by oxidative stress due to continued exposure to noise. This noise-induced stress decreases with rosuvastatin therapy.

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“…Therefore, detailed studies focusing on the endothelial cell responses during hyperglycemia was still needed. MicroRNAs (miRNAs) were an abundant class of endogenous, noncoding transcripts of [18][19][20][21][22][23][24][25] nucleotides. MiRNAs are considered as a novel sort of gene regulators, by binding to their target Introduction ▼ Diabetes, as well as its associated complications, was a frequent and increasing public health problem in modern society.…”

Section: Mir-21 Is Overexpressed In Response To High Glucose and Protmentioning

confidence: 99%

MiR-21 is Overexpressed in Response to High Glucose and Protects Endothelial Cells from Apoptosis

Zeng

Xiong

et al. 2013

Exp Clin Endocrinol Diabetes

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Diabetes was an increasing public health problem nowadays. Accumulating evidences had shed a light on the involvement of endothelial cell dysfunction in the pathogenesis of diabetes-associated vascular diseases. MiR-21, a multiple-functional miRNA, was evidenced to be involved in endothelial dysfunction, however, the underlying molecular mechanisms were still unknown. In current study, we investigated the intrinsic link between miR-21 and high glucose-induced endothelial dysfunction. We demonstrated that expression of miR-21 was elevated in circulating endothelial progenitor cells from diabetes patients. Further, inhibition of miR-21 markedly enhanced high glucose-induced endothelial cytotoxicity. Furthermore, proteomic profiling was applied to analyze the downstream effectors involved in miR-21-meidated protection of endothelial cells. A total of 31 proteins were positively identified, including Annexin A2, S100A4, SOD2, Thioredoxin and DAXX. Altered expression of these proteins was validated by immunoblot. Finally, mechanistic study showed that miR-21 protected endothelial cell against high glucose-induced endothelial cytotoxicity probably by inhibiting the expression of DAXX. Our findings were considered as a significant step toward a better understanding of diabetes-associated vascular diseases.

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The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose

Cited by 37 publications

References 25 publications

Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

MiR-21 is Overexpressed in Response to High Glucose and Protects Endothelial Cells from Apoptosis

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