The purity identification and radiolabeling of α-mangostin with technetium-99m

Muchtaridi, Muchtaridi; Setyawati, Luthfi Utami; Islamiaty, Risda Rahmi; Lie, Kevin Reinard; Nurhidayah, Wiwit

doi:10.4103/japtr.japtr_94_19

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Contoh pengotor radiokimia dalam kompleks bertanda 99m Tc adalah pertechnetate ( 99m TcO4 -) bebas dan 99m Tc terhidrolisis. 13,14 Uji kemurnian radiokimia harus dilakukan dengan waktu yang singkat agar efisien karena radioisotop yang terkandung didalam radiofarmaka mudah meluruh dengan waktu paro yang cukup singkat. Uji kemurnian radiokimia umumnya menggunakan metode kromatografi lapis tipis karena pengerjaannya relatif mudah, waktu yang digunakan singkat, serta biaya pengerjaan relatif murah.…”

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Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

Chaerunisa¹,

Rosilawati²,

Muchtaridi³

2022

IJPST

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Coronary Heart Disease (CHD) is a heart disorder caused by blockage of blood vessels. CHD can bedetected by Myocardial Perfusion Imaging (MPI). MPI is performed by injecting a radiopharmaceuticalinto the patient's body. 99mTc-sestamibi is a radiopharmaceutical that is commonly used in MPI.Sestamibi is available in the form of a multidose vial, but the cost of the examination will be expensiveif it is only used for one patient. Cost effectiveness can be increased by fractionating the sestamibi kitbefore labelled by 99mTc. 99mTc-sestamibi needs to be tested for quality control before it is administeredto the patients. One of the tests is the radiochemical purity test. The aim of this study was to determinethe radiochemical purity of the fractionated sestamibi kit labelled by 50 mCi 99mTc. 2 vials of sestamibikit was fractionated by adding 5 mL of 0.9% NaCl solution to each vial and divided into 10 new vials.Radiochemical purity was measured using the thin layer chromatography (TLC) method. The resultsof this study indicated that all samples had radiochemical purity of 100% up to 6 hours after labellingKeywords: Radiopharmaceutical, 99mTc-sestamibi, fractionation, radiochemical purity

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unclassified

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

Chaerunisa¹,

Rosilawati²,

Muchtaridi³

2022

IJPST

Self Cite

View full text Add to dashboard Cite

show abstract

“…Pengotor dapat terjadi karena adanya radioisotop bebas, produk degradasi, atau produk limbah selama proses reaksi. Contoh pengotor radiokimia dalam kompleks bertanda 99m Tc adalah pertechnetate ( 99m TcO4 -) bebas dan 99mTc terhidrolisis 13,14 .…”

unclassified

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

Chaerunisa

Rosilawati²,

Muchtaridi

2022

IJPST

View full text Add to dashboard Cite

Coronary Heart Disease (CHD) is a heart disorder caused by blockage of blood vessels. CHD can bedetected by Myocardial Perfusion Imaging (MPI). MPI is performed by injecting a radiopharmaceuticalinto the patient's body. 99mTc-sestamibi is a radiopharmaceutical that is commonly used in MPI.Sestamibi is available in the form of a multidose vial, but the cost of the examination will be expensiveif it is only used for one patient. Cost effectiveness can be increased by fractionating the sestamibi kitbefore labelled by 99mTc. 99mTc-sestamibi needs to be tested for quality control before it is administeredto the patients. One of the tests is the radiochemical purity test. The aim of this study was to determinethe radiochemical purity of the fractionated sestamibi kit labelled by 50 mCi 99mTc. 2 vials of sestamibikit were fractionated by adding 5 mL of 0.9% NaCl solution to each vial and divided into 10 new vials.Radiochemical purity was measured using the thin layer chromatography (TLC) method. The resultsof this study indicated that all samples had radiochemical purity of 100% up to 6 hours after labelling.

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General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review

Setyawati

Nurhidayah

Ikram

et al. 2023

Heliyon

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The purity identification and radiolabeling of α-mangostin with technetium-99m

Cited by 6 publications

References 10 publications

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m

General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review

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