The Relation Between Lung Dust and Lung Pathology in Pneumoconiosis

Nagelschmidt, G.

doi:10.1136/oem.17.4.247

Cited by 40 publications

(37 citation statements)

References 25 publications

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“…For instance, an exposure to silica with concomitant dusts could be insucient to induce health eects at the same loads of retained silica that would produce silicosis if it was in a relatively pure state (Nagelschmidt 1960;Wallace et al 1995). This surprising phenomenon may re¯ect a modulation of silica surface properties by other substances, and could have important implications for the prevention of silicosis.…”

Section: Resultsmentioning

confidence: 97%

8-Hydroxydeoxyguanosine in leukocyte DNA and urine of quartz-exposed workers and patients with silicosis

Pilger

Germadnik

Schäffer

et al. 2000

International Archives of Occupational and Environmental Health

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Section: Resultsmentioning

confidence: 97%

8-Hydroxydeoxyguanosine in leukocyte DNA and urine of quartz-exposed workers and patients with silicosis

Pilger

Germadnik

Schäffer

et al. 2000

International Archives of Occupational and Environmental Health

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“…This is in contrast to intratracheal administration of dust (Schoenberger et al, 1982) and acute toxic agents such as bleomycin (Snider et al, 1978). It is also in contrast to the human situation, where pure dust exposures are rare and the environment contains many respirable pathogenic agents (Nagelschmidt, 1960). It may be that crocidolite is a weak fibrogenic agent that requires co-agents or prior inflammatory response to produce a rapid and severe fibrotic lesion.…”

Section: Discussionmentioning

confidence: 98%

Asbestos‐induced changes in rat lung parenchyma

Johnson

1987

Journal of Toxicology and Environmental Health

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Fischer 344 rats have been exposed to UICC crocidolite by whole-body inhalation procedures for periods of 1 d to 12 mo. Material was obtained from the same location in the left lung, and the numbers of cells in the parenchyma were identified and determined by transmission electron microscopy. An immediate increase (1 d of exposure) was evident in the number of type II cells, suggesting a direct action of the dust on these cells. The number of interstitial and alveolar macrophages showed a significant increase after 3 mo of exposure. The number of alveolar macrophages containing dust particles after a 1-d exposure was 49%, and the corresponding value after 12 mo of exposure was 92%. The longer periods of exposure were associated with an increase in the number of particles per macrophage. Polymorphs appeared in the interstitium at airway bifurcations, prior to their appearance in the alveolar space. These bifurcations were also the initial sites where evidence of cell damage and collagen deposition was seen. In this experiment crocidolite appears to be weakly fibrogenic, and other factors may be needed to produce the marked lesions seen in human asbestosis.

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“…The interleukin-4 and the growth factors stimulate fibroblasts to proliferate and produce collagen around the silica particle, thus resulting in fibrosis and the formation of nodular lesions. 3,4 In this report, our patient with a typical occupational history of stone mining for a decade and chest imaging result was diagnosed silicosis by definite histopathology result.…”

Section: Discussion Of Managementmentioning

confidence: 99%

“…2,3 While some others believed the trace metals found on silica dusts played the major role in silicosis pathogenesis. 4,5 Risk of lung cancer is 3 folds more in silicosis than in general population. 6 Patients with silicosis are 20-30 folds more susceptible to pulmonary tuberculosis.…”

Section: Pathological Discussionmentioning

confidence: 99%