The Relationship Between Anion Gap and Elevated Lactate

Mehta, Ketan C.; Kruse, Janes A.; Carlson, Richard W.

doi:10.1097/00003246-198604000-00186

Search citation statements

Order By: Relevance

Paper Sections

Select...

Clinical Utility Of Anion Gap1

Identifying Unmeasured Anions1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1987

2020

Publication Types

Select...

Book4

Article2

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 24 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unmeasured anions have been reported in the blood of patients with sepsis [35,36], patients with liver disease [37,38], and experimental animals that received endotoxin [39]. These anions may be the source of much of the unexplained acidosis seen in patients with critical illness [40].…”

Section: Clinical Utility Of Anion Gapmentioning

confidence: 99%

Acid–Base Physiology

Agarwal

Liepert

2014

Surgical Metabolism

View full text Add to dashboard Cite

Section: Clinical Utility Of Anion Gapmentioning

confidence: 99%

Acid–Base Physiology

Agarwal

Liepert

2014

Surgical Metabolism

View full text Add to dashboard Cite

“…They proposed that disturbances in the oxidation of succinate to oxaloacetate could account for this. Interest in this area was rekindled by studies on critically ill patients in which elevations in anion gap could not be accounted for solely by increased lactate levels [11,12]. Further work examining the concentrations of other hitherto unmeasured ions such as urate and phosphate as well as plasma proteins could not account for the observed anion gap [13,14].…”

Section: Identifying Unmeasured Anionsmentioning

confidence: 99%

Untitled

2006

View full text Add to dashboard Cite

In the critically ill, metabolic acidosis is a common observation and, in clinical practice, the cause of this derangement is often multifactorial. Various measures are often employed to try and characterise the aetiology of metabolic acidosis, the most popular of which is the anion gap. The purpose of the anion gap can be perceived as a means by which the physician is alerted to the presence of unmeasured anions in plasma that contribute to the observed acidosis. In many cases, the causative ion may be easily identified, such as lactate, but often the causative ion(s) remain unidentified, even after exclusion of the 'classic' causes. We describe here the various attempts in the literature that have been made to address this observation and highlight recent studies that reveal potential sources of such hitherto unmeasured anions.

show abstract

Controversies in Lactic Acidosis

Mizock¹

1987

JAMA

View full text Add to dashboard Cite

Lactic acidosis is common in critically ill patients and is usually caused by tissue perfusion that is inadequate to meet metabolic demand. However, it has also been noted in conditions in which tissue perfusion is apparently adequate. Hyperlactatemia can occur in the absence of acidosis, usually in the setting of hypermetabolic disease. Numerous areas of controversy exist regarding the pathogenesis of lactic acidosis, as well as certain of its diagnostic, therapeutic, and prognostic features. Knowledge of these areas of controversy should facilitate the clinician's approach to diagnosis and management.

show abstract

The Relationship Between Anion Gap and Elevated Lactate

Cited by 24 publications

References 0 publications

Acid–Base Physiology

Acid–Base Physiology

Untitled

Controversies in Lactic Acidosis

Contact Info

Product

Resources

About