The relationship between stool weight and the lithocholate/deoxycholate ratio in faeces

Brydon, W. G.; Eastwood, M. A.; Elton, R. A.

doi:10.1038/bjc.1988.145

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…LCA: DCA has been suggested to be an indicator for the risk of colo-rectal cancer in humans (Owen et al 1983). It has been observed in humans that there is a significant regression for log,, LCA:DCA v. log,, stool weight (Brydon et al 1988). In the present animal experiment we observed a similar result; log,, LCA(tota1): DCA(tota1) was well correlated with log,, faecal dry weight (Fig.…”

Section: Discussionsupporting

confidence: 88%

Effects of oat rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus)

et al. 1993

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The effects of bran and starchy endosperm fractions of oat and rye on faecal weight and on biliary and faecal bile acids were studied in Syrian golden hamsters (Mesocricetus auratus). The animals fed on diets supplemented with steam-flaked oat bran, oat bran or rye bran had higher wet and dry weights of faeces compared with the animals fed on the fibre-free or low-fibre endosperm diets. A higher mean percentage of biliary cholic acid and a lower mean percentage of chenodeoxycholic and Lithocholic (LCA) acids was observed in the bran-supplemented dietary groups. Animals fed on the bran-supplemented diets had increased daily faecal excretion of both total saponifiable and total free bile acids compared with the animals fed on fibre-free or endosperm-supplemented diets. The mean percentage of total saponifiable bile acids in the faeces was higher, and that of free bile acids lower in the animals fed on bransupplemented diets. A significantly lower concentration of faecal free LCA was observed in the animals fed on the rye-bran diet. Both bran and endosperm diets reduced the faecal LCA:deoxycholic acid compared with the fibre-free diet, but the bran diets had a more pronounced effect than endosperm diets.

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Section: Discussionsupporting

confidence: 88%

Effects of oat rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus)

et al. 1993

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“…The observation (Zhang et al 1993) that the LCA:DCA ratio in the bile is well correlated with that in the faeces implies that rye bran may, in some way, affect the metabolism of the microflora in the large intestine. It is also proposed (Brydon et al 1988) that dietary fibre may reduce transit time and thus make less time available for fermentation and reabsorption of secondary bile acids especially lithocholic acid which is poorly absorbed. Low SBA: PBA and LCA: DCA ratios have been suggested to be related to a lower risk of colon cancer in humans (Turjman et al 1984;Owen et al 1986Owen et al , 1987.…”

Section: Discussionmentioning

confidence: 99%

Effects of rye bran, oat bran and soya-bean fibre on bile composition, gallstone formation, gall-bladder morphology and serum cholesterol in Syrian golden hamsters (Mesocricetus auratus)

et al. 1994

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~The effects of rye bran, oat bran and soya-bean fibre on serum lipids, bile composition and gallstone formation were studied in male Syrian golden hamsters (Mesocvicetus auvatus). The control groups received fibre-free stone-provoking (01 diet) or non-stone-provoking ( 0 2 diet) diets. The serum cholesterol levels were lower for all groups fed on the diets supplemented with the dietary fibre sources compared with the control groups. The total content of bile acids in bile was higher in groups given ryebran diets compared with the corresponding controls. The proportion of cholic acid was higher and that of chenodeoxycholic and lithocholic acid lower in the groups given rye-bran-, oat-bran-or soya-beanfibre-supplemented diets, compared with the corresponding controls. The secondary : primary bile acid ratio was lower in the group given the rye-bran-supplemented 0 1 diet. The lithocho1ic:deoxycholic acid ratio was lower in the groups given rye-bran-, oat-bran-or soya-bean-fibre-supplemented diets than in the corresponding controls. A lower frequency of gallstones was observed only for the group receiving the rye-bran-supplemented 01 diet while the lithogenic index was lower in the groups given the rye-bransupplemented 0 2 diet. A decreased epithelial volume density of the gall-bladder and an increased smooth muscular volume density were observed in animals given oat-bran-and rye-bran-supplemented 0 1 diets, whereas for the soya-bean-fibre-supplemented 0 1 diet, only the smooth muscular volume density was increased.Rye bran: Oat bran: Soya-bean fibre: Bile: Serum lipids: Hamsters

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Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber)

et al. 1992

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The relationship between stool weight and the lithocholate/deoxycholate ratio in faeces

Cited by 9 publications

References 13 publications

Effects of oat rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus)

Effects of oat rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus)

Effects of rye bran, oat bran and soya-bean fibre on bile composition, gallstone formation, gall-bladder morphology and serum cholesterol in Syrian golden hamsters (Mesocricetus auratus)

Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber)

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