Background: Healthcare organization managers need to be far more nimble and adaptable to thrive in a cutthroat market. In order to foster organizational agility, administrators, managers, and leaders in the healthcare industry must provide the highest level of patient and employee needs, expectations, and demands. Organizational agility has a mediating role in fostering professional development and career goals for nurses transitioning into advanced practice, as well as improving nurses' competence (Al Humdan, Shi, and Behnia, 2020). Aim: The current study conducted to investigate the relation between organizational agility and career aspirations as perceived by staff nurses at selected hospitals. Research design: A descriptive correlational design was utilized to carry out the present study. Setting: The current study was conducted at