The Risk Factors of Coronary Heart Disease and its Relationship with Endothelial Nitric Oxide Synthase

Abstract

BACKGROUND: Coronary heart disease (CHD) is the leading cause of death and start with injury to the endothelium of a coronary artery. The common feature of endothelial dysfunction is a decrease of nitric oxide (NO) bioavailability that regulated by endothelial NO synthase (eNOS) activity. AIM: The aim of our study was to study the relationship between risk factors of CHD patients with the level of eNOS. METHODS: Thirty-seven outpatients in cardiology department of the regional public hospital diagnosed as CHD were included in our study. Thirty healthy individuals were included as the control group. Risk factors of CHD were identified according to anamnesis and laboratory finding. eNOS was measured by ELISA methods. RESULTS: Endothelial NOS levels were significantly higher in the CHD when compared to the controls (p < 0.05). The most dominant risk factor for CHD is overweight, and followed by dyslipidemia, smoking, hypertension, history of CHD, and diabetes mellitus. eNOS in CHD patients who had one risk factor was 37.598 ± 0.1541 ng/ml, two risk factors 42.154 ± 22.329 ng/ml, three risk factors 25.329 ± 6.083 ng/ml, four risk factors 22.483 ± 4.022 ng/ml, and five risk factors 15.994 ± 4.774 ng/ml. There were significant differences in the average eNOS levels based on the number of risk factors (p < 0.05), and a tendency that more risk factors in CHD patients, the lower the average level of eNOS. CONCLUSION: In our study, eNOS levels showed highly significant relation with CHD and related to the number of risk factors those the CHD patients had.

Ramipril Increases Adma Concentration in Acute Myocardial Infarction in Rats Induced by Isoproterenol

“…Particularly, the inhibition of eNOS results in decreased NO levels, which is a crucial signaling molecule in endothelial cells involving cardiovascular diseases. The NO levels released by eNOS in endothelial cells are essential for the maintenance of basal vascular tone [15], [16], [17].…”

Gambaran Faktor yang Mempengaruhi Kejadian Penyakit Jantung Koroner (PJK) di Pusat Jantung Terpadu (PJT)

“…Penyakit tidak menular (PTM) merupakan salah satu penyebab angka kematian tertinggi di dunia. Salah satu jenis PTM yang menyebabkan kematian tertinggi adalah penyakit jantung atau oenyakit kardiovaskular (Elfi et al, 2021). Penyakit Kardiovaskular merupakan penyakit penyebab kematian dan kecacatan di negara maju maupun berkembang.…”