Kadar troponin T memberikan informasi penting dalam estimasi luas infark. Pada IMA, luas infark berhubungan erat dengan nilai prognosis. Luas infark yang melebihi 40% miokardium juga berkaitan dengan tingginya insiden syok kardiogenik. Keadaan ini yang diduga mendasari perburukan klinis pasien IMA sehingga dapat mempengaruhi lama perawatan. Tujuan penelitian ini adalah menganalisis hubungan kadar troponin T deng  n lama perawatan  pasien Infark Miokard Akut (IMA) di RSUP Dr. M. Djamil Padang dengan menggunakan desain penelitian Cross Sectional Study. Penelitian ini menggunakan data sekunder yang diambil di Instalasi Rekam Medik (Medical Record), yaitu data rekam medik pasien yang didiagnosis sebagai IMA yang dirawat inap di RSUP Dr. M. Djamil Padang periode 01 Januari – 31 Desember 2013. Data dianalisis dengan uji korelasi Spearman. Hasil penelitian ini menemukan sebagian besar pasien IMA masuk rumah sakit dengan kadar kadar Troponin T sebesar 0,1-2 ng/ml (68,0%) dan lama hari rawat sebesar ≥ 5 hari (74,0%). Berdasarkan hasil analisis bivariat yang telah dilakukan, dapat disimpulkan bahwa tidak terdapat hubungan signifikan antara kadar troponin T dengan lama perawatan pasien IMA dengan nilai p>0,05 dan nilai koefisien korelasi Spearman (r)=0,160 yang menunjukkan korelasi positif dengan derajat hubungan yang lemah/tidak ada hubungan.

AbstrakPenyakit arteri perifer (peripheral arterial disease, PAD) merupakan kumpulan kelainan yang menghambat aliran darah ke ekstremitas, pada umumnya terjadi akibat aterosklerosis dan bermanifestasi sebagai klaudikasio. Disamping terapi medikamentosa dan endovaskuler yang optimal, manajemen non farmakologi PAD terbukti efektif mengurangi gejala, meningkatkan kemampuan berjalan dan kualitas hidup. Telah dilaporkan laki-laki usia 58 tahun penderita klaudikasio intermitten karena oklusi arteri iliaka komunis sinistra. Pasien masih merasakan gejala setelah terapi medikamentosa dan angioplasty tranluminal percutaneous. Setelah dilakukan program latihan disupervisi, gejala, kemampuan berjalan, dan indeks brachial ankle meningkat signifikan. Program latihan disupervisi pada pasien PAD dinilai penting sebagai terapi primer untuk meningkatkan kapasitas fungsional dan kualitas hidup untuk manajemen jangka panjang.AbstractPeripheral arterial disease (PAD) is a disorder that obstruct the arterial blood supply to extremities, most commonly caused by atherosclerosis and manifests as claudicatio. Aside from optimal medical therapy and endovascular therapy, non pharmacological managements of PAD are proven effectively improving symptoms, increasing walking distance, and overall quality of life. The case report describe a 58 years old male with known claudicatio intermitten due to occlusion of left communis iliac artery. After medical therapy and percutaneous transluminal angioplasty, the patient still symptomatic. After supervised exercise training was prescribed to the patient, the symptom, walking distance, and ankle brachial index was improved significantly. Rehabilitation in PAD with supervised exercise training plays significant role as primary therapy in patients with PAD to improve functional capacity and quality of life in long term management.

Infark Miokard Akut Elevasi Segmen ST (IMA-EST) merupakan masalah kesehatan dengan morbiditas dan mortalitas yang tinggi di dunia. IMA-EST adalah gejala iskemia infark khas yang dikaitkan dengan gambaran EKG berupa elevasi segmen ST yang persisten. Kejadian IMA-EST tidak terlepas dengan berbagai faktor risiko serta manajemen reperfusi yang didapat pasien. Tujuan penelitian ini adalah untuk mengetahui gambaran faktor risiko dan manajemen reperfusi pasien IMA-EST di bangsal jantung RSUP Dr. M. Djamil Padang. Penelitian ini bersifat deskriptif retrospektif. Penelitian ini dilaksanakan pada Januari 2016-Maret 2016. Sampel penelitian adalah seluruh pasien IMA- EST yang memenuhi kriteria inklusi dan kemudian dilakukan pencatatan dari beberapa variabel yang diteliti. Hasil penelitian ini menunjukkan IMA-EST dengan karakteristik rentang usia terbanyak 45-54 tahun dengan jenis kelamin laki-laki. Faktor risiko yang paling banyak dimiliki adalah hipertensi dan merokok. Intervensi Koroner Perkutan (IKP) merupakan terapi yang paling sering dilakukan dengan waktu tindakan lebih dari 12 jam pasca infark.

Objective: The aim with the present study was to determine that arginine affect to the level of IL-6, IL-17 and TGF-β in high-fat diet-induced hypercholesterolemia in rats. Material and Methods: Male Wistar rats in eight weeks old (n=35) were divided into five groups, one group as a control (C) were given standard r fed and four groups were given high-fat diet (Hfd) with fats from beef tallow. One group of high-fat diet rats recieved no arginine, three groups were recieved arginine in doses of 100, 200 and 400 mg/kg/day each for three weeks. After two weeks of treatment, blood cholesterol were measured, while serum level of IL-6, IL-17 and TGF-β were measured at the final five weeks of this protocol by ELISA methods. Results: There were no significantly different between groups, which received different doses of arginine (p>0,05). IL-17 of high-fat diet received arginine of doses 100 and 200 mg/kg/day were significantly higher compared to high-fat diet received no arginine and control group. Interestingly, IL-17 in high-fat diet group received arginine of doses 400 mg/kg/day were lower compared to groups received lower doses of arginine. TGF-β levels in the high-fat diet group's recieved arginine were lower compared to control group. Conclusions: The effect of arginine on cytokines plays the role on vascular inflammation due to high-fat diet. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

BACKGROUND: Coronary heart disease (CHD) is the leading cause of death and start with injury to the endothelium of a coronary artery. The common feature of endothelial dysfunction is a decrease of nitric oxide (NO) bioavailability that regulated by endothelial NO synthase (eNOS) activity. AIM: The aim of our study was to study the relationship between risk factors of CHD patients with the level of eNOS. METHODS: Thirty-seven outpatients in cardiology department of the regional public hospital diagnosed as CHD were included in our study. Thirty healthy individuals were included as the control group. Risk factors of CHD were identified according to anamnesis and laboratory finding. eNOS was measured by ELISA methods. RESULTS: Endothelial NOS levels were significantly higher in the CHD when compared to the controls (p < 0.05). The most dominant risk factor for CHD is overweight, and followed by dyslipidemia, smoking, hypertension, history of CHD, and diabetes mellitus. eNOS in CHD patients who had one risk factor was 37.598 ± 0.1541 ng/ml, two risk factors 42.154 ± 22.329 ng/ml, three risk factors 25.329 ± 6.083 ng/ml, four risk factors 22.483 ± 4.022 ng/ml, and five risk factors 15.994 ± 4.774 ng/ml. There were significant differences in the average eNOS levels based on the number of risk factors (p < 0.05), and a tendency that more risk factors in CHD patients, the lower the average level of eNOS. CONCLUSION: In our study, eNOS levels showed highly significant relation with CHD and related to the number of risk factors those the CHD patients had.