The Role of Osteoimmunology in Periodontal Disease

Kayal, Rayyan A.

doi:10.1155/2013/639368

Cited by 84 publications

(90 citation statements)

References 119 publications

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“…A partir de esta se obtiene el índice de apnea-hipoapnea (IAH), el cual se calcula dividiendo el número de eventos por el número de horas de sueño, que es la forma más útil y objetiva de clasificar la severidad de la enfermedad. El uso del IAH en el SAHOS puede clasificarse como leve (IHA [5][6][7][8][9][10][11][12][13][14]9), moderado (IHA 15-29,9) o grave (IHA ≥ 30) (10).…”

Section: El Reporte De La Academia Americana De Medicina Delunclassified

“…Estas células liberan citocinas, como interleucina 1 (IL-1), interleucina 6 (IL-6), factor nuclear kappa beta (NF-κβ), factor de necrosis tumoral alfa (TNF-α) (3)(4)(5), rank ligando (RANK-L) y prostaglandina E2 (PGE2), que inducen la pérdida ósea (6). La respuesta inflamatoria local resultante de la periodontitis puede desencadenar una respuesta sistémica inflamatoria y constituirse en un factor de riesgo para patologías como enfermedad cardiovascular, diabetes, artritis y osteoporosis (7).…”

Section: Introductionunclassified

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Condición periodontal de pacientes con apnea obstructiva del sueño / Periodontal Status of Patients with Obstructive Sleep Apnea

et al. 2016

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RESUMENAntecedentes: Existen patologías sistémicas que tienen relación directa con la enfermedad periodontal; por esto es necesario identificarlas para controlarlas y así evitar que esta condición se agrave. Objetivo: Describir la condición periodontal de los pacientes que asistieron a un estudio polisomnográfico. Métodos: Este fue un estudio descriptivo de corte transversal. La muestra incluyó 166 pacientes con estudio polisomnográfico previo a quienes se les realizó el examen periodontal para determinar su diagnóstico periodontal fundamentado en la clasificación de Armitage, de 1999, y subclasificado de acuerdo con la localización. Resultados: De los 166 pacientes evaluados, el 99,40 % presentó afectación periodontal, de quienes el 71,08 % presentó síndrome de apnea/hipoapnea del sueño (SAHOS); el 58,4 %, periodontitis, y el 36,74 %, gingivitis. Las patologías de mayor prevalencia correspondieron al 60,39 % del total de la muestra y fueron gingivitis inducida por biopelícula con pérdida de inserción preexistente, periodontitis crónica severa localizada y periodontitis crónica moderada localizada. Afectaron a los pacientes con el diagnóstico de SAHOS en un 41,11 % y en el 19,28 % restante a los pacientes sin SAHOS. Conclusiones: El diagnóstico de mayor prevalencia en los pacientes que asistieron al examen polisomnográfico fue gingivitis con pérdida de inserción preexistente generalizada. El diagnóstico de periodontitis en pacientes con SAHOS estuvo más relacionado con la presencia de factores locales. A mayor severidad del diagnóstico periodontal, menor número de dientes presentes en boca, mayor movilidad, mayor cantidad de furcas afectadas, menor frecuencia de cepillado y mayor edad.PALABRAS CLAVE apnea obstructiva del sueño; enfermedad periodontal; hipoapnea obstructiva del sueño; periodontitis; síndrome de apnea o hipoapnea obstructiva del sueño (SAHOS) ÁREAS TEMÁTICAS neumología; otorrinolaringología; periodoncia ABSTRACT Background: There are systemic diseases that are directly related to periodontal disease, so it is necessary to identify them, in order to control them and prevent the worsening of this condition. Objective: To describe the periodontal condition of patients who underwent polysomnographic analysis. Methods: This was a cross-sectional study. The sample included 166 patients with prior polysomnography, who underwent periodontal examination to determine periodontal diagnosis based on the classification of Armitage 1999 and sub-classified according to location. Results: Of the 166 patients evaluated, 99.40 % had periodontal diseases, of which 71.08 % had obstructive sleep apnea/hypopnea syndrome (OSA), periodontitis 58.4% and gingivitis 36.74 %. The most prevalent periodontal diseases corresponded to 60.39 % of the total sample and gingivitis with preexisting insertion loss, severe chronic periodontitis, and moderate chronic periodontitis affected 41.11 % of patients with the diagnosis of OSA and remaining 19.28 % did not have OSA. Conclusions: The most prevalent diagnosis in patients with poly...

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Section: El Reporte De La Academia Americana De Medicina Delunclassified

Section: Introductionunclassified

Condición periodontal de pacientes con apnea obstructiva del sueño / Periodontal Status of Patients with Obstructive Sleep Apnea

et al. 2016

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“…In addition, MCPs, IP-10 and RANTES are chemotactic factors for monocytes/macrophages and T helper cells. IP-10 is a ligand for the CXCR3 receptor present in Th1 cells (15). Here, the expression of the MCP-1, RANTES and IP-10 chemokines were detected in gingival tissue in all periods studied, although all the chemokines expression was significantly higher in the PD60 group.…”

Section: Discussionmentioning

confidence: 66%

Evolution of Periodontal Disease: Immune Response and RANK/RANKL/OPG System

et al. 2017

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The aim of this study was to evaluate markers of bone loss and immune response present in evolution of periodontal disease. One hundred and two Wistar rats were divided into three animals groups: PD0, without ligation and PD15 days and PD60 days, submitted to ligation placement with a sterile 3-0 silk cord in the cervical region of the upper first molar on both sides. Samples were obtained from the gingival tissue for histomorphometric analysis, immunohistochemical analysis of RANK, RANKL, OPG, characterization of the inflammatory infiltrate, quantification of nitric oxide, MCP-1, RANTES, IP10 chemokines, and expression of the TGF-β1, VEG, and bFGF. The number of inflammatory cells in gingival tissue was higher in PD60 samples. The collagen content and the area occupied by birefringent collagen fibers were lower for PD60. Differential leukocyte counting showed that there was a significantly higher polymorphonuclear influx in group PD15, while PD60 showed a greater number of lymphocytes. PD60 showed higher RANTES, IP-10, MCP-1 gene transcripts, as well as a higher nitric oxide concentration. Clinical evaluation revealed that the PD60 group presented an increase in furcal area. In conclusion, in this animal model the increase of RANK/RANKL and HGF markers is related to a specific immune response, and probably contributed to the evolution of periodontal disease. Investigating the effect of these biomarkers can help in targeted therapy for bone resorption, since blocking these can inhibit bone loss.

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“…Taken together, these results suggest that FimA-specific plantibody is reactive with native fimbriae present on P. gingivalis; therefore, the plantibody can block The role of neutrophils or polymorphonuclear cells (PMNs) has generally been accepted as a double-edged sword in periodontitis (53). PMNs play an essential role in host defense against bacteria, while an excessive release of toxic products such as lysosomal enzymes and oxygen radicals during the microbial killing process has the potential to cause tissue destruction (53,54). The major protective function of the PMN, phagocytosis and killing of bacteria, is often dependent on serum opsonization (55).…”

Section: Discussionmentioning

confidence: 99%