The Role of Serum and Follicular IL-1Beta in Predicting the ICSI Outcome in Infertile Women

Comparing the ICSI outcome between different causes of subfertility and estimate the role of IL-1β in predicting ICSI outcome.

“…A lower pregnancy rate is found in patients with unexplained subfertility. This is concomitant with the significantly higher serum interleukins IL-1β level in the group of patients with unexplained subfertility so that it may be a negative predictor for ICSI outcome, and this was agreed with a study done by Rihab et al, which showed that there is a negative correlation between the serum IL-1β and ICSI outcome (6). Our finding can be explained that ICSI itself leads to no significant association between the subfertility cause and the clinical outcome as (25) had stated.…”

“…The physiological regulation of the ovary is a complicated process ; the growth factor, steroid hormones, gonadotropins, and cytokines all take part. Immune cells in the ovary cause immune-endocrine interaction ; this modulates the ovarian function through secreting a soluble regulatory factor, especially the cytokines (6). Inflammatory cytokines are found in many compartments of the ovary, such as the follicles.…”

Follicular fluid 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as biomarker for oxidative stress in intracytoplasmic sperm injection

“…Table (2) compares the level of 8-OHdG between the two groups (pregnant and non-pregnant) by independent sample t-test. As shown in the table, the level of 8-OHdG in the FF of pregnant women is lower than the non-pregnant women ; the difference was highly statistically significant (p < 0.05).…”

“…Subfertility is the failure to get pregnant despite having regular and unprotected (non-contraceptive) intra-vaginal sexual relationships for 12 months (1,2). Oxidative stress (OS) is a situation that results from un-equilibrium between reactive oxygen species (ROS) formation and the antioxidant defense system.…”