The Role of the Posterior Hypothalamus in the Modulation and Production of Rhythmic Theta Oscillations

Kowalczyk, Tomasz; Staszelis, Agata; Kazmierska-Grebowska, Paulina; Tokarski, Krzysztof; Caban, Bartosz

doi:10.1016/j.neuroscience.2021.07.001

Cited by 11 publications

(19 citation statements)

References 157 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Timing cells are a particularly interesting subtype of posterior hypothalamic neurons when considering the dual function of the PHa in theta field potential generation. As presented earlier, the PHa is considered a crucial part of the ascending brainstem‐hippocampal synchronizing system and is involved in the emergence and control of theta appearance in the hippocampal formation (Bland & Oddie, 1998; Kowalczyk et al, 2021; Pignatelli et al, 2012; Vertes, 1992). On the other hand, the SuM and posterior hypothalamic nuclei are capable of generating local theta field potentials (Grass et al, 1995; Kocsis & Vertes, 1997; Kowalczyk et al, 2014; Ruan et al, 2011; Sławińska & Kasicki, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The MSDB collects inputs from lower parts of the ascending synchronizing system (the pontine nuclei, SuM, and PH), processes this information, and distributes outputs to the entorhinal cortex, cingulate cortex, and the hippocampal formation, that is, limbic structures in which theta field potentials are locally generated (Bland, 1986; Bland & Oddie, 1998). The SuM and the posterior hypothalamic nuclei are considered together as the posterior hypothalamic area (PHa) and are involved in frequency programming and modulation of rhythmic theta activity observed in limbic sites (Bland et al, 1995; Bland & Oddie, 1998; Kirk, 1998; Kowalczyk et al, 2021; Oddie et al, 1994; Pan & McNaughton, 2002; Vertes, 1992; Woodnorth et al, 2003). Additionally, there is accumulating data showing that this diencephalic region is not only capable of controlling and modulating limbic theta rhythm but is also an independent generator of theta field potentials.…”

Section: Introductionmentioning

confidence: 99%

“…The SuM and the posterior hypothalamic nuclei are considered together as the posterior hypothalamic area (PHa) and are involved in frequency programming and modulation of rhythmic theta activity observed in limbic sites (Bland et al, 1995;Kirk, 1998;Kowalczyk et al, 2021;Oddie et al, 1994;Pan & McNaughton, 2002;Vertes, 1992;Woodnorth et al, 2003). Additionally, there is accumulating data showing that this diencephalic region is not only capable of controlling and modulating limbic theta rhythm but is also an independent generator of theta field potentials.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Posterior hypothalamic theta rhythm: Electrophysiological basis and involvement of glutamatergic receptors

et al. 2023

Self Cite

View full text Add to dashboard Cite

The posterior hypothalamic area (PHa), including the supramammillary nucleus (SuM) and posterior hypothalamic nuclei, forms a crucial part of the ascending brainstem hippocampal synchronizing pathway, that is involved in the frequency programming and modulation of rhythmic theta activity generated in limbic structures. Recent investigations show that in addition to being a modulator of limbic theta activity, the PHa is capable of producing well‐synchronized local theta field potentials by itself. The purpose of this study was to examine the ability of the PHa to generate theta field potentials and accompanying cell discharges in response to glutamatergic stimulation under both in vitro and in vivo conditions. The second objective was to examine the electrophysiological properties of neurons located in the SuM and posterior hypothalamic nuclei. Extracellular in vivo and in vitro as well as intracellular in vitro experiments revealed that glutamatergic stimulation of PHa with kainic acid induces well‐synchronized local theta field oscillations in both the supramammillary and posterior hypothalamic nuclei. Furthermore, the glutamatergic PHa theta rhythm recorded extracellularly was accompanied by the activity of specific subtypes of theta‐related neurons. We identify, for the first time, a subpopulation of supramammillary and posterior hypothalamic neurons that express clear subthreshold membrane potential oscillations in the theta frequency range.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Posterior hypothalamic theta rhythm: Electrophysiological basis and involvement of glutamatergic receptors

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, the supramammillary nucleus contained dense AR labeling. This area, considered a part of the posterior hypothalamus, is implicated to play a role in memory, movement, learning, emotion, and arousal (Kowalczyk et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Androgen receptors in the forebrain: A study in adult male cats

Coolen

Cambier

Asselt

et al. 2023

Journal of Morphology

View full text Add to dashboard Cite

Androgens and their receptors are present throughout the body. Various structures such as muscles, genitals, and prostate express androgen receptors. The central nervous system also expresses androgen receptors. Androgens cross the blood-brain barrier to reach these central areas. In the central nervous system, androgens are involved in multiple functions. The current study investigated in which forebrain areas androgens are expressed in the male cat. Androgen receptor immunoreactive (AR-IR) nuclei were plotted and the results were quantified with a Heidelberg Topaz II + scanner and Linocolor 5.0 software. The density and intensity of the labeled cells were the main outcomes of interest. The analysis revealed a dense distribution of AR-IR nuclei in the preoptic area, periventricular complex of the hypothalamus, posterior hypothalamic area, ventromedial hypothalamic, parvocellular hypothalamic, infundibular, and supramammillary nucleus. Numerous AR-IR cells were also observed in the dorsal division of the anterior olfactory nucleus, lateral septal nucleus, medial and lateral divisions of the bed nucleus of the stria terminalis, lateral olfactory tract nucleus, anterior amygdaloid area, and the central and medial amygdaloid nuclei. AR-IR nuclei were predominantly observed in areas involved in autonomic and neuroendocrinergic responses which are important for many physiological processes and behaviors.

show abstract

“…Additionally, the anterodorsal thalamic nucleus expressed cFOS at higher levels at P5 and P9 than the adult, while the septum showed expression at all ages. Together, these regions can be roughly clustered into the "head-direction circuit" (Taube, 2007) and the "ascending brainstem-hippocampal synchronizing pathway" that modulates theta-band oscillations (∼4-10 Hz) (e.g., Kowalczyk et al, 2021) and their initial points of entry to the entorhinal and hippocampal cortex.…”

Section: Early Activation Of the Egocentric Monitoring Systemsmentioning

confidence: 99%

cFOS as a biomarker of activity maturation in the hippocampal formation

Pompeiano

Colonnese

2023

Front. Neurosci.

View full text Add to dashboard Cite

We explored the potential for cFOS expression as a marker of functional development of “resting-state” waking activity in the extended network of the hippocampus and entorhinal cortex. We examined sleeping and awake mice at (P)ostnatal days 5, 9, 13, and 17 as well as in adulthood. We find that cFOS expression is state-dependent even at 5 days old, with reliable staining occurring only in the awake mice. Even during waking, cFOS expression was rare and weak at P5. The septal nuclei, entorhinal cortex layer (L)2, and anterodorsal thalamus were exceptional in that they had robust cFOS expression at P5 that was similar to or greater than in adulthood. Significant P5 expression was also observed in the dentate gyrus, entorhinal cortex L6, postsubiculum L4-6, ventral subiculum, supramammillary nucleus, and posterior hypothalamic nucleus. The expression in these regions grew stronger with age, and the expression in new regions was added progressively at P9 and P13 by which point the overall expression pattern in many regions was qualitatively similar to the adult. Six regions—CA1, dorsal subiculum, postsubiculum L2-3, reuniens nucleus, and perirhinal and postrhinal cortices—were very late developing, mostly achieving adult levels only after P17. Our findings support a number of developmental principles. First, early spontaneous activity patterns induced by muscle twitches during sleep do not induce robust cFOS expression in the extended hippocampal network. Second, the development of cFOS expression follows the progressive activation along the trisynaptic circuit, rather than birth date or cellular maturation. Third, we reveal components of the egocentric head-direction and theta-rhythm circuits as the earliest cFOS active circuits in the forebrain. Our results suggest that cFOS staining may provide a reliable and sensitive biomarker for hippocampal formation activity development, particularly in regard to the attainment of a normal waking state and synchronizing rhythms such as theta and gamma.

show abstract

The Role of the Posterior Hypothalamus in the Modulation and Production of Rhythmic Theta Oscillations

Cited by 11 publications

References 157 publications

Posterior hypothalamic theta rhythm: Electrophysiological basis and involvement of glutamatergic receptors

Posterior hypothalamic theta rhythm: Electrophysiological basis and involvement of glutamatergic receptors

Androgen receptors in the forebrain: A study in adult male cats

cFOS as a biomarker of activity maturation in the hippocampal formation

Contact Info

Product

Resources

About