The Saga of Endocrine FGFs

Phan, Phuc; Saikia, Bibhuti Ballav; Sonnaila, Shivakumar; Agrawal, Shilpi; Alraawi, Zeina; Kumar, Thallapuranam Krishnaswamy Suresh; Iyer, Shilpa

doi:10.3390/cells10092418

Cited by 38 publications

(28 citation statements)

References 267 publications

(593 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FGF21 was first identified in 2000 principally in the liver (131) but was first described as a metabolic regulator in 2005 (132), involved in lipid metabolism, by decreasing adipose tissue lipolysis, increasing fatty acid oxidation and reducing hepatic lipids. Secondly, it is involved in glucose metabolism by decreasing plasma glucose, which mainly explain its higher circulating expression in patients with obesity and/or hepatic steatosis as a compensatory effect (14,133).…”

Section: Fgf21mentioning

confidence: 99%

“…Secondly, it is involved in glucose metabolism by decreasing plasma glucose, which mainly explain its higher circulating expression in patients with obesity and/or hepatic steatosis as a compensatory effect (14,133). In addition to its metabolic regulator role, FGF21 has been reported as a potential anti-diabetic therapy thanks to its ability to improve b-cell function and mass (132). This anti-diabetic role is explained by different mechanisms: decrease in plasma glucose and triglyceride levels which reduces b-cells' glucolipotoxicity and activate AKT signaling pathway which improves insulin sensitivity (14,134,135).…”

Section: Fgf21mentioning

confidence: 99%

See 1 more Smart Citation

Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

et al. 2022

View full text Add to dashboard Cite

The regulation of insulin secretion is under control of a complex inter-organ/cells crosstalk involving various metabolites and/or physical connections. In this review, we try to illustrate with current knowledge how β-cells communicate with other cell types and organs in physiological and pathological contexts. Moreover, this review will provide a better understanding of the microenvironment and of the context in which β-cells exist and how this can influence their survival and function. Recent studies showed that β-cell insulin secretion is regulated also by a direct and indirect inter-organ/inter-cellular communication involving various factors, illustrating the idea of “the hidden face of the iceberg”. Moreover, any disruption on the physiological communication between β-cells and other cells or organs can participate on diabetes onset. Therefore, for new anti-diabetic treatments’ development, it is necessary to consider the entire network of cells and organs involved in the regulation of β-cellular function and no longer just β-cell or pancreatic islet alone. In this context, we discuss here the intra-islet communication, the β-cell/skeletal muscle, β-cell/adipose tissue and β-cell/liver cross talk.

show abstract

Section: Fgf21mentioning

confidence: 99%

Section: Fgf21mentioning

confidence: 99%

Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

et al. 2022

View full text Add to dashboard Cite

show abstract

“…FGFs contain a homologous core region of 120-130 amino acids arranged into 12 antiparallel β-strands, flanked by divergent amino-and carboxyl-termini. Sequence variation of the amino-and carboxyl-terminal tails usually accounts for the different biological functions of FGFs [3,4]. To date, twenty-two FGFs and four FGFRs have been identified in mammals.…”

Section: Introductionmentioning

confidence: 99%

Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

Shimizu

Sato

2022

Cells

View full text Add to dashboard Cite

Fibroblast growth factors (FGFs) play important roles in various growth signaling processes, including proliferation, development, and differentiation. Endocrine FGFs, i.e., atypical FGFs, including FGF15/19, FGF21, and FGF23, function as endocrine hormones that regulate energy metabolism. Nutritional status is known to regulate the expression of endocrine FGFs through nuclear hormone receptors. The increased expression of endocrine FGFs regulates energy metabolism processes, such as fatty acid metabolism and glucose metabolism. Recently, a relationship was found between the FGF19 subfamily and stress signaling during stresses such as endoplasmic reticulum stress and oxidative stress. This review focuses on endocrine FGFs and the recent progress in FGF studies in relation to stress signaling. In addition, the relevance of the stress–FGF pathway to disease and human health is discussed.

show abstract

“…Recently, the scenario of possible biomarkers in chronic renal failure has been enriched by new players such as Fibroblast Growth Factor-23 (FGF-23) and Klotho. The progressive deterioration of renal function is characterized by a progressive reduction of Klotho protein and an increase of the FGF-23 levels [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

Guarneri

Scola

Giarratana

et al. 2022

Genes

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is characterized by an increased risk of kidney failure and end-stage renal disease (ESRD). Aging and comorbidities as cardiovascular diseases, metabolic disorders, infectious diseases, or tumors, might increase the risk of dialysis. In addition, genetic susceptibility factors might modulate kidney damage evolution. We have analyzed, in a group of ESRD patients and matched controls, a set of SNPs of genes (Klotho rs577912, rs564481, rs9536314; FGF23 rs7955866; IGF1 rs35767; TNFA rs1800629; IL6 rs1800795; MIF rs755622, rs1007888) chosen in relation to their possible involvement with renal disease and concomitant pathologies. Analysis of the raw data did indicate that IL6 rs180795 and MIF rs755622 SNPs might be markers of genetic susceptibility to ESRD. In particular, the C positive genotypes of MIF rs755622, (dominant model) seem to be an independent risk factor for ESDR patients (data adjusted for age, gender, and associated pathologies). Stratifying results according to age MIF rs755622 C positive genotype frequencies are increased in both the two age classes considered (<59 and ≥59-year-old subjects). Analyses of data according to gender allowed us to observe that ESRD women shoved a significantly reduced frequency of genotypes bearing IL6 rs180795 C allele. In addition, MIF rs755622 might interact with diabetes or hypercholesterolemia in increasing susceptibility to ESRD. In conclusion, our data indicate that some polymorphisms involved in the regulation of both renal function and inflammatory response can influence the evolution of chronic kidney disease and suggest that the modulation of the activities of these and other genes should also be considered as therapeutic targets on to intervene with innovative therapies.

show abstract

The Saga of Endocrine FGFs

Cited by 38 publications

References 267 publications

Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

Contact Info

Product

Resources

About