The screening and evaluation of herbs and identification of herbal combinations with anti-viral effects on Newcastle disease virus

Wang, M.; Yu, Ying; Brad, Korbanjhon; Xie, Wenyan; Zhang, X.-Y.

doi:10.1080/00071668.2015.1119245

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…APS regulates immune functions by stimulating the release of cytokines and affecting the secretion of immunoglobulin and conduction of immune signals. The immunomodulatory effects of APS against various viruses have been demonstrated (Shi et al, 2014;Xue et al, 2015;Wang et al, 2016;Zheng et al, 2020). APS has also been investigated for its enhancement of the immunity of COVID-19 patients (Adhikari et al, 2020;Meletis and Wilkes, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Honeysuckle is safe to be used as food and medicine because it has been used for thousand years of practicing TCM (Li RJ et al, 2020). Moreover, Huangqi is rich in the anti-viral immunomodulatory compound Astragalus polysaccharide (APS) (Shi et al, 2014;Xue et al, 2015;Wang et al, 2016;Zheng et al, 2020); thus, it may be effective against SARS-CoV-2 infections.…”

Section: Introductionmentioning

confidence: 99%

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Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro

et al. 2022

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COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host immunity, but not both. Traditional Chinese medicine (TCM) compounds could be promising candidates due to their safety and minimal toxicity. In this study, we have developed a novel in silico bioinformatics workflow that integrates multiple databases to predict the use of honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) as potential anti-SARS-CoV-2 agents. Using extracts from honeysuckle and Huangqi, these two herbs upregulated a group of microRNAs including let-7a, miR-148b, and miR-146a, which are critical to reduce the pathogenesis of SARS-CoV-2. Moreover, these herbs suppressed pro-inflammatory cytokines including IL-6 or TNF-α, which were both identified in the cytokine storm of acute respiratory distress syndrome, a major cause of COVID-19 death. Furthermore, both herbs partially inhibited the fusion of SARS-CoV-2 spike protein-transfected BHK-21 cells with the human lung cancer cell line Calu-3 that was expressing ACE2 receptors. These herbs inhibited SARS-CoV-2 Mpro activity, thereby alleviating viral entry as well as replication. In conclusion, our findings demonstrate that honeysuckle and Huangqi have the potential to be used as an inhibitor of SARS-CoV-2 virus entry that warrants further in vivo analysis and functional assessment of miRNAs to confirm their clinical importance. This fast-screening platform can also be applied to other drug discovery studies for other infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro

et al. 2022

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“…Among these, 5 herbs that have the highest inhibitor effect are used including Herba agastaches, Flos chrysanthemi indici, Rhizoma anemarrhenae, Astragalus root, and Baikal skullcap root. The results suggested that formulation components have a synergistic effect to improve NDV resistance (Wang et al, 2016). These are some researches on Chinese herbal medicine in recent years for the control and treatment of the New Castle Disease Virus.…”

Section: Chinamentioning

confidence: 89%

Utilisation of Herbal Bullets against Newcastle Disease in Poultry Sector of Asia and Africa (2012-2022)

2023

IJAB

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Poultry industry is rapidly booming in developing countries with increased demand for consumption. Reportedly, chicken meat is highly expected to be used as a major source of protein. With rising popularity and expansion comes greater risk to health and economic losses due to lethal diseases like New Castle disease. Such diseases not only make flocks vulnerable to morbidity but also increases mortality risks for the whole flock. Thus, controlling, managing, and treating these diseases is direly needed. Developing countries, for example, Asian and African countries, rely on a number of control methods and treatments. One of these is the use of ethnoveterinary medicine. Many researchers have also tested the efficacy of these medicines in various terms. In Pakistan, Azadirachta indica, Nigella sativa, Glycyrrhiza glabra, Iresine herbstii, etc. have been found effective against Newcastle Disease. Phyllanthus embolic, Curcuma long and Ocimum tenuiflorum, Allium cepa, Cuminum cyminum, Withania somnifera, Tinospora cordifolia, Allium sativum, Azadirachta indica, Trigonella foenum-graecum and Laurus nobilis are also found effective against ND in India. China is the largest poultry industry in the world that has also been employing various ethnoveterinary medicines for disease control in farms. Some of the most used ethnoveterinary medicines include Astragalus membranaceus, Angelicae sinensis extract and Danggui Buxue San, Scutellaria baicalensis, Chinese plant, ginseng (Chinese plant) stem-leaf saponins, Rheum rhabarbarum, Glycyrrhiza glabra, Sijunzi Decoction, Dangguibuxue Tang and Morus alba with vaccine adjuant. In African countries, Ethnoveterinary botanical medicines are also used. The use of Allium sativum, Azadirachta indica, Allium sativum with NDV lasota vaccine, Aloe barbadensis miller, Moringa oleifera, Lagenaria breviflora, Cucumis metuliferus, Piper guineense, Aframomum melegueta, and Psidium guajava are known to be effective. Survey-based studies in Ethiopia have shown that Acmella caulirhiza, Zingibar officinale, Mixture of Alcohol, Citrus limon and Allium cepa, Capsicum annum, Rumex abyssinicus root and Brasica compestris are used as ethnoveterinary Similarly, In Zimbabwe, Capsicum annum, Sesamum angustifolium fruit, Tridactyle bicaudata leaves, Strychnos cocculoides, Senna singueana leaves, Abyssinia bark, Aloe greatheadii pods, and other aloe species are used effectively against NDV. This literature review will highlight some herbs and ethnoveterinary medicines that have been researched to be effective against Newcastle Disease.

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Determination of flavonoids inFlos ChrysanthemiandFlos Chrysanthemi Indiciby capillary electrophoresis

Rong

2016

Instrumentation Science & Technology

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The screening and evaluation of herbs and identification of herbal combinations with anti-viral effects on Newcastle disease virus

Cited by 6 publications

References 12 publications

Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro

Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro

Utilisation of Herbal Bullets against Newcastle Disease in Poultry Sector of Asia and Africa (2012-2022)

Determination of flavonoids inFlos ChrysanthemiandFlos Chrysanthemi Indiciby capillary electrophoresis

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