The value of serum uric acid in predicting adverse pregnancy outcomes of women with hypertensive disorders of pregnancy

Jing, Lin; Hong, Xun-Yu; Tu, Rong-Zu

doi:10.5603/gp.a2018.0064

Cited by 6 publications

(5 citation statements)

References 17 publications

(20 reference statements)

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“…The odds ratio of adverse pregnancy outcomes with serum uric acid levels >357μmol/L was 1.258, p<0.05. 11 This is similar to the findings of the current study, as stated above. Two other studies reported similar findings.…”

Section: Discussionsupporting

confidence: 92%

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Correlation of Uric Acid Levels with Feto-Maternal Outcomes in Hypertensive Disorders in Pregnancy

Saleem

Noman²,

Yaqub³

et al. 2023

PAFMJ

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Objective: To explore the correlation between uric acid levels and feto-maternal outcomes in women with hypertensive disorders of pregnancy. Study Design: Comparative cross-sectional study. Place and Duration of Study: Obstetrics & Gynaecology Department, Combined Military Hospital, Rawalpindi Pakistan, from Feb to Aug 2021. Methodology: In this cross-sectional study, 90 pregnant women with hypertensive disorders having greater than 26 weeks of gestation were included after seeking Ethical Committee approval. Selected parameters were noted on a structured proforma. Results: Among the participants, 38(42.2%) had pregnancy-induced hypertension, 32(35.5%) had pre-eclampsia, 13(14.5%) had chronic hypertension with pre-eclampsia, and 7(7.8%) had eclampsia. Mean Uric acid levels ranged between 363.66±50.45 μmol/L and 451.86±120.62μmol/L, with a significant difference between PIH and eclampsia (p<0.001). Mode of delivery was avaginal, primary cesarean section, and repeat cesarean section in 31(34.4%), 38(42.2%), and 21(23.4%) patients, respectively(p<0.001). Liquor was meconium stained in 49(54.4%) while clear in 41(45.6%) births, with (p<0.001). Early neonatal deaths6(6.7%) participants had significantly higher uric acid levels than no NICU admission 22(24.4%). In maternal outcomes, 83 patients (92.2%) required routine post-operative care, while 7(7.8 %) went to the intensive care unit. Uric acid levels had a negative correlation with gestational age. Conclusion: Maternal uric acid levels differ significantly in different hypertensive disorders of pregnancy and affect the mode of delivery and neonatal outcomes.

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Section: Discussionsupporting

confidence: 92%

“…The sample size was calculated using Net's sample size calculator taking 6% Population Proportion. 11 The subjects were enrolled through nonprobability, consecutive technique.…”

Section: Methodsmentioning

confidence: 99%

Correlation of Uric Acid Levels with Feto-Maternal Outcomes in Hypertensive Disorders in Pregnancy

Saleem

Noman²,

Yaqub³

et al. 2023

PAFMJ

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“…In a study by Lin et al from 2015 to 2017, 180 pregnant women with hypertensive disease of pregnancy were put into two sub Group-s based on their uric acid levels. 13 One Group-had raised maternal serum uric acid (n=137), and the other had normal levels (n=43). The pregnancy outcomes were compared with another Group of 180 healthy pregnant women.…”

Section: Discussionmentioning

confidence: 96%

Maternal Serum Uric Acid as a Marker of Predicting Low Birth Weight at Term Pregnancy: A Study Based in CMH Lahore

Ghaffar

Nawaz

Shaheen

et al. 2022

PAFMJ

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Objective: To determine the association of hyperuricemia with adverse pregnancy outcomes in terms of low birth weight at term pregnancy registered at CMH Lahore. Study Design: Prospective cohort study. Place and Duration of Study: Department of Obstetrics and Gynecology of CMH, Lahore Pakistan, from Aug 2018 to Feb 2019. Methodology: A total of 60 pregnant women with a singleton pregnancy were included in the study. Patients with serum uric acid levels greater or equal to 360 umol/L were included in Group-A or the at-risk Group, and Patients with serum uric acid levels less than 360 umol/L were included in Group-B or the control Group. All women were followed till the delivery. Data regarding adverse pregnancy outcomes (low birth weight) was noted. Results: Mean Serum uric acid levels of 380.33±12.92 umol/L in the Exposed Group and mean Serum uric acid levels of 265.66±29.44 umol/L in the Control Group were noted. Low birth weight was seen 12 (40%) in Exposed Group as compared to 7(23.3%) in Unexposed Group (p=0.165) (RR=1.71). Conclusion: Low birth weight at term was not associated with hyperuricemic pregnancy more than normouricemic pregnancy in our study, probably due to the small sample size.

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“…4 One study found that frequency of low birth weight was 36.2% in women having hyperuricemia & hypertension during pregnancy. 5 Study carried by Ryu et al mean uric acid level was 5.8 ranging from (4.7 -6.6) in pre-eclamptic women compared to 3.9 and ranging from (3.1 -4.6) in patients with normal blood pressure. Pre-eclampsia was associated significantly with preterm labor, LBW (low birth weight) and SGA (small for Gestational age).…”

Section: Introductionmentioning

confidence: 94%

Assessment Of Predictive Value Of Serum Uric Acid Levels For Low Birth Weight In Pre-Eclampsia

Asma,

Muntaha,

Liaqat

et al. 2023

JRMC

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OBJECTIVE: To assess the diagnostic accuracy of raised serum uric acid level in females with pre-eclampsia, in predicting low birth weight. SUBJESTS & METHODS: Cross sectional study carried out at Gynecology Department, FGSH Poly Clinic, Islamabad & duration of study was 6 months from July 21, 2021 to Jan 20, 2022. A total of 225 Preeclampsia pregnant female were clinically examined and included in the study. Blood sample were collected for serum uric acid and followed till the birth of the baby. RESULTS: The study included age ranged from 18 up to 40 years. Average age was 28.69years +5.01SD. Sensitivity & specificity of uric acid level in Serum in diagnosis of low birth weight are 85.71% and 81.42% respectively while it has positive predictive & negative predictive value of 51.43% & 96.13% respectively. Diagnostic accuracy of uric acid level in serum was 82.22%. CONCLUSION: Uric acid level in serum is of great diagnostic and prognostic importance in women with pre-eclampsia & helps in predicting low birth weight.

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The value of serum uric acid in predicting adverse pregnancy outcomes of women with hypertensive disorders of pregnancy

Abstract: Women with HDP and HUA are often accompanied with a variety of abnormal biochemical indicators, and is correlated with the severity of the disease and APOs.

Cited by 6 publications

References 17 publications

Correlation of Uric Acid Levels with Feto-Maternal Outcomes in Hypertensive Disorders in Pregnancy

Correlation of Uric Acid Levels with Feto-Maternal Outcomes in Hypertensive Disorders in Pregnancy

Maternal Serum Uric Acid as a Marker of Predicting Low Birth Weight at Term Pregnancy: A Study Based in CMH Lahore

Assessment Of Predictive Value Of Serum Uric Acid Levels For Low Birth Weight In Pre-Eclampsia

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