Therapeutic Applications of Naringenin, a Flavanone Enriched in Citrus Fruits, for Disorders beyond Diabetes

Abstract

In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than diabetes and its role in regulating gene expression by altering chromatin structure as histone deacetylase inhibitor. The understanding of these phenomena will increase the overall knowledge of the various health-promoting effects of citrus fruits.

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“…15 The pharmacological and curative activities of naringenin on human health have been intensively studied showing a multitude of beneficial effects, such as anti-carcinogenic, anti-estrogenic, anti-atherosclerotic, anti-diabetic, anti-viral, anti-bacterial, etc . 16–18 Complementary to its applicability in the medical field, naringenin is also used in perfumery and cosmetics. In the domain of materials, there are only very few studies reporting the use of naringenin.…”