Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Alotaibi, Badriyah; Ijaz, Munazza; Buabeid, Manal; Kharaba, Zelal; Yaseen, Hafiza Sidra; Murtaza, Ghulam

doi:10.2147/dddt.s327238

Cited by 52 publications

(17 citation statements)

References 113 publications

(117 reference statements)

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“…Polyphenols occupy an important place in the life of plants by intervening in their metabolism. There are known about 8.000 plant-derived polyphenol compounds with antioxidant and antitumor properties [53][54][55][56][57][58]. Polyphenols are organic, watersoluble compounds that contain in their molecule one or more aromatic rings with one or more hydroxyl groups.…”

Section: Polyphenols -Chemical Structure and Classificationmentioning

confidence: 99%

On Overview Of Bioactive Compounds, Biological And Pharmacological Effects Of Mistletoe (Viscum Album L)

Kleszken¹,

Timar²,

Memete³

et al. 2022

Pharmacophore

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The genus Viscum includes many species that are mainly distributed in Europe, Africa, Asia, America, and Australia. Viscum extracts or their various preparations are widely used as complementary and alternative medicines in the treatment of various ailments. In the present review, articles related to the phytochemical composition of mistletoe were selected, depending on the host tree on which it grows, as well as articles in which its beneficial effects were highlighted. Viscum contains different active ingredients, including lectins, viscotoxins along with phenolic acids, flavonoids, alkaloids, terpenoids, and polysaccharides. Based on its composition, mistletoe extract is associated with multiple bioactivities, including anticancer, anti-inflammatory, and cardiovascular disease, attenuating the side effects of chemotherapy and enhancing immunity. The purpose of this review was to highlight the link between the host tree and the bioactive components of mistletoe such as lectin and viscotoxin, with a focus on phenolic compounds such as flavonoids and phenolic acids. The potential therapeutic effects of mistletoe are summarized by subspecies and host trees. Numerous mistletoe-based patents with various applications have been developed and presented in this review. Mistletoe is a medicinal plant with great biological potential that is worth exploring for various targeted treatments.

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Section: Polyphenols -Chemical Structure and Classificationmentioning

confidence: 99%

On Overview Of Bioactive Compounds, Biological And Pharmacological Effects Of Mistletoe (Viscum Album L)

Kleszken¹,

Timar²,

Memete³

et al. 2022

Pharmacophore

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show abstract

“…The plant-derived polyphenolic compounds exert powerful antioxidant activity and have showed their beneficial effects in cardiovascular disease, such as DIC (149). The polyphenolic compounds can be classified as flavonoids, stilbenes, phenolic acids, and lignans based on the molecular structure (150).…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Chen

Yan

Yang

2022

Front. Cardiovasc. Med.

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Left ventricular (LV) mass loss is prevalent in doxorubicin (DOX)-induced cardiotoxicity and is responsible for the progressive decline of cardiac function. Comparing with the well-studied role of cell death, the part of cardiomyocyte atrophy (CMA) playing in the LV mass loss is underestimated and the knowledge of the underlying mechanism is still limited. In this review, we summarized the recent advances in the DOX-induced CMA. We found that the CMA caused by DOX is associated with the upregulation of FOXOs and “atrogenes,” the activation of transient receptor potential canonical 3-NADPH oxidase 2 (TRPC3-Nox2) axis, and the suppression of IGF-1-PI3K signaling pathway. The imbalance of anabolic and catabolic process may be the common final pathway of these mechanisms. At last, we provided some strategies that have been demonstrated to alleviate the DOX-induced CMA in animal models.

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“…Globally, due to extensive changes in living standards throughout the past 10 years, society's inclination towards natural productivity and a healthy lifestyle has now shifted to processed food and a sedentary way of life 14 . The risk features of cardiac disorders have increased with such harmful lifestyle factors with increased smoking.…”

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic, hypoglycaemic and antioxidative potential of Juglans Regia (walnuts) in an experimental animal model of dietary hyperlipidemia.

Sangi

Shamim

Khan

2022

Int. j. endorsing health sci. res.

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Background: Cardiovascular diseases (CVD) are recognized as the world's primary cause of fatality, particularly in the developing countries. Stroke and ischemic heart disease have reportedly been the principal manifestations of vascular disease mainly because of the gradual increase in the incidence of the risk factors. In this aspect, the present study is planned to investigate the cardio-protective potential of Juglans regia (JR) (walnuts) consumption in controlling dyslipidemia. JR has notable therapeutic effects and, it has been used since ancient times for its anti-inflammatory, cardio-protective, and anti-bacterial properties. Methodology: In this study, 32 age-matched females, Wistar albino rats of 5-6 weeks weighing 200 g, were selected and equally divided into four experimental groups. Group I was used as control, Group II was positively induced hyperlipidemia through a high-fat diet; Group III animals were fed normal rat chow along with 153 mg JR powder, and Group IV animals have also inducted hyperlipidemia through a high-fat diet incorporated with 153 mg JR powder/Kg for 15 days. Bodyweight changes along with daily diet consumption were measured on alternate days. Results: In comparison to the control group, animals fed with a high-fat diet (Group II) showed a non-significant increase in plasma lipid profile, total cholesterol (TC), triglycerides (TG), and plasma high-density lipoprotein (HDL) levels. Group III and IV animals, after walnut powder supplementation, showed a significant decrease in lipid profile change in very Low-Density Lipoprotein levels (VLDL) of 10.3 ± 0.60 mg/dl and 12.27 ± 0.94 mg/dl together with nephron-protective & reno-protective enzymatic alterations. Histological analysis revealed signs of inflammation in high fat treated groups while well-maintained cardiac tissues within walnut treated groups, respectively. Conclusion: Daily consumption of Juglans Regia (walnut) in the dosage mentioned earlier is beneficial in protectively modulating dyslipidemia, hyperglycemic, and oxidative tissue potential of high-fat diet consumption in an experimental animal model.

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Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review

Cited by 52 publications

References 113 publications

On Overview Of Bioactive Compounds, Biological And Pharmacological Effects Of Mistletoe (Viscum Album L)

On Overview Of Bioactive Compounds, Biological And Pharmacological Effects Of Mistletoe (Viscum Album L)

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Antihyperlipidemic, hypoglycaemic and antioxidative potential of Juglans Regia (walnuts) in an experimental animal model of dietary hyperlipidemia.

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