Therapeutic effects of ginsenosides on breast cancer growth and metastasis

Jin, Yujin; Huynh, Diem Thi Ngoc; Nguyen, Thuy Le Lam; Jeon, Hyesu; Heo, Kyung‐Sun

doi:10.1007/s12272-020-01265-8

Cited by 29 publications

(15 citation statements)

References 111 publications

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“…The activity of ginsenoside Rh2 against different types of cancer cells is mediated by upregulating miR-146a-5p, miR-21, miR-491, and miR128 ( 158 – 160 ) or by downregulating miR-4295, miR-31, and miR-638 ( 146 , 161 – 163 ). In addition, treatment with the ginsenoside Rh2 reduces anti-tumor drug resistance in breast cancer cells by reducing the expression of miR-222, miR-34a, and miR-29a ( 147 ). Further, treatment with 20(S)-ginsenoside Rg3 reverses epithelial–mesenchymal transition in ovarian cancer cells by downregulating DNMT3A-mediated miR-145 ( 148 ).…”

Section: Epigenetic Enzymes As Anticancer Targets Of Natural Compound...mentioning

confidence: 99%

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

et al. 2022

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Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor suppressor genes is closely associated with the occurrence, progression, and prognosis of tumors. Based on the reversibility of epigenetic mechanisms, small-molecule compounds that target epigenetic regulation have become promising therapeutics. These compounds target epigenetic regulatory enzymes, including DNA methylases, histone modifiers (methylation and acetylation), enzymes that specifically recognize post-translational modifications, chromatin-remodeling enzymes, and post-transcriptional regulators. Few compounds have been used in clinical trials and exhibit certain therapeutic effects. Herein, we summarize the classification and therapeutic roles of compounds that target epigenetic regulatory enzymes in cancer treatment. Finally, we highlight how the natural compounds berberine and ginsenosides can target epigenetic regulatory enzymes to treat cancer.

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Section: Epigenetic Enzymes As Anticancer Targets Of Natural Compound...mentioning

confidence: 99%

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

et al. 2022

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“…It also acts as an inhibitor of MDM2, which might be a potential target in BC therapy. These novel natural products are involved in downregulating the MDM2 pathway, thus acting as promising candidates for BC treatment [ 97 ].…”

Section: Downstream Regulation Of Signaling Pathways By Natural Productsmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. This review focused on the emerging roles of novel natural products and derived bioactive compounds as therapeutic agents against BC. The present review also discussed the mechanism of action through signaling pathways and the synergistic approach of natural compounds to improve their efficacy. We discussed the recent in vivo and in vitro studies for exploring the overexpression of oncogenes in the case of BC and the current status of newly discovered natural products in clinical investigations.

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“…Studies have shown that ginsenosides can mediating numerous processions of BC, including drive apoptosis and autophagy, regulate cell cycle and inhibit metastasis ( Jin et al, 2020 ). At present, a variety of ginsenosides have been reported to inhibit the proliferation of BC, such as ginsenoside Rg3 and ginsenoside Rd can inhibit the metastasis of BC cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

et al. 2022

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Breast cancer (BC) is one of the most common malignant tumor, the incidence of which has increased worldwide in recent years. Ginsenosides are the main active components of Panax ginseng C. A. Mey., in vitro and in vivo studies have confirmed that ginsenosides have significant anti-cancer activity, including BC. It is reported that ginsenosides can induce BC cells apoptosis, inhibit BC cells proliferation, migration, invasion, as well as autophagy and angiogenesis, thereby suppress the procession of BC. In this review, the therapeutic effects and the molecular mechanisms of ginsenosides on BC will be summarized. And the combination strategy of ginsenosides with other drugs on BC will also be discussed. In addition, epigenetic changes, especially microRNAs (miRNAs) targeted by ginsenosides in the treatment of BC are clarified.

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Therapeutic effects of ginsenosides on breast cancer growth and metastasis

Cited by 29 publications

References 111 publications

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

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