Therapeutic Potential of Dietary Phenolic Acids

Abstract

Although modern lifestyle has eased the quality of human life, this lifestyle's related patterns have imparted negative effects on health to acquire multiple diseases. Many synthetic drugs are invented during the last millennium but most if not all of them possess several side effects and proved to be costly. Convincing evidences have established the premise that the phytotherapeutic potential of natural compounds and need of search for novel drugs from natural sources are of high priority. Phenolic acids (PAs) are a class of secondary metabolites spread throughout the plant kingdom and generally involved in plethora of cellular processes involved in plant growth and reproduction and also produced as defense mechanism to sustain various environmental stresses. Extensive research on PAs strongly suggests that consumption of these compounds hold promise to offer protection against various ailments in humans. This paper focuses on the naturally derived PAs and summarizes the action mechanisms of these compounds during disease conditions. Based on the available information in the literature, it is suggested that use of PAs as drugs is very promising; however more research and clinical trials are necessary before these bioactive molecules can be made for treatment. Finally this review provides greater awareness of the promise that natural PAs hold for use in the disease prevention and therapy.

Antioxidant Potential and its Correlation with the Contents of Phenolic Compounds and Flavonoids of Methanolic Extracts from Different Medicinal Plants

“…6,7 Besides the reducing power of phenolic groups, many others therapeutic activities exhibited by plants, such as anti-HIV activity, the control of diabetes and cardiovascular diseases, and anti-inflammatory and anticarcinogen properties, are related to this class of compounds. 8,9 In Brazil, there is increasing interest in studying the antioxidant potential of natural compounds, which is mainly due to high biodiversity and the considerable number of plants already used in popular medicine. 6 There are currently many assays that can be used to determine antioxidant activity in vitro.…”

Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes

“…This might attribute to an increase in glucose utilization through mitochondrial respiratory chain which promotes peripheral glucose utilization by enhancing anaerobic glycolysis (Coller, ). In the study of Saibabu et al (), treatment with ellagic acid markedly elevated the insulin‐secreting activity from pancreatic β‐cell, which attenuated the dyslipidemia. On the other hand, ellagic acid could indirectly attenuate hypoglycemic effects through regulating blood glucose homeostasis and glucose uptake which were mediated through AMP‐activated protein kinase (AMPK) activation (Li, Yao, & Li, ).…”

“…It has been reported that ellagic acid plays cardioprotective, hepatoprotective, and gastroprotective roles in human body (Beserra et al, ). Meanwhile, p ‐coumaric acid has been proved to generate antiaging, anticancer, and antidiabetes functions (Saibabu, Fatima, Khan, & Hameed, ). Piceid, a precursor of resveratrol, had anticarcinogenic effects, antioxidation activity, and inhibition of platelet aggregation (Su et al, ).…”

Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model

“…The reduction in RBC and Hb levels at higher doses hypothesized potent competitive interaction among inorganic substances particularly Ca 2+ , Mn 2+ , Zn 2+ , Cd 2+ , and Pb 2+ . Previous studies had shown that hematotoxic effects could be traced to additive, competitive, or antagonistic interactions of macro‐nutrients overload, all of which eventually interrupts hematopoiesis (Akintunde, Oboh, & Akindahunsi, 2015; Kaustav, Melanie, Abishek, David, & Matthew, 2016; Venkata, Zeeshan, Luqman, & Saif, 2015). Moreover, the reduction in the levels of RBC and Hb at higher doses may be linked to the remarkable dietary depletion of Mn 2+ and Zn 2+ levels by MCF‐MORS.…”