Therapeutic use of platelet-rich plasma in oral surgery

Lazić, Zoran; Bubalo, Marija; Petković-Ćurčin, Aleksandra; Dukat, Milos; Mihajlović, Branko

doi:10.2298/vsp0910821l

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…This result is consistent with the role of WPLTs and PRP in promoting the proliferation of dental pulp cells, indicating that both PRP and WPLTs can be used for retention repair or for the regeneration treatment of dental pulp. However, the method for activation of blood platelets in WPLT used in our study is a simple physical approach (liquid nitrogen freeze-thawing) and therefore the overall biological safety of WPLTs is superior to that of PRP (Lazić et al, 2009). In addition, PRP exhibits a jelly-like consistency after being activated by bovine thrombin and it is difficult therefore to mix it sufficiently with the biological pulp capping material.…”

Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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ABSTRACT. We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used to observe the formation of mineralized nodules after cell mineralization and induction for 10 and 20 days under different culture conditions, and the areas of the mineralized nodules formed 20 days after induction were computed. The addition of 1, 10, and 100 mL/L WPLTs or PRP significantly promoted rat dental pulp cell proliferation (P < 0.05) whereas 500 mL/L WPLTs or PRP had no significant effect (P > 0.05). Under the same concentrations, no significant differences on cell proliferation were observed between WPLT and PRP treatments (P > 0.05 in all groups). After 10 days mineralization and culture, the 100 and 500 mL/L WPLT and PRP group positive nodule rates were significantly higher than those of the low concentration and the control groups (P < 0.05). After 20 days, the areas of the mineralized nodules formed in the 100 and 500 mL/L WPLT and 9487 Effects of WPLTs and PRP on rat dental pulp cells ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9486-9496 (2015) PRP groups were significantly larger than those in the control group (P < 0.05). These results demonstrate that both WPLTs and PRP are equally able to significantly promote the proliferation and calcification of rat dental pulp cells under a certain range of concentrations.

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Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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“…Blood growth factors chiefly originate in blood plasma and platelets. Among these, the essential growth factors are platelet derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and insulin-like growth factor 1 (IGF 1) [13,14]. It has been documented that blood obtained through patient venipuncture can be used to generate fibrin-rich gel (PRF) [4,6,15,16].…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

et al. 2020

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Background : The combined application of surgical and therapeutic modalities to improve the rate and or degree of healing and tissue regeneration is gaining in popularity. Aim : This study describes two case reports using piezoelectric surgery (PES), concentrated growth factors (CGF) and photobiomodulation (PBM) as a means of enhancing angiogenesis and tissue regeneration following dental implant sinus lift procedures. Materials and Methods : Sinus lateral windows were created using PES and the sinus membrane raised to make a new partition. Dental implants were inserted concurrently and packed with autologous fibrin rich CGF. Wound sites underwent PBM treatment using a multiwave locked system laser. The efficacy of the multidisciplinary approach was assessed by radiographic and clinical evaluation one, three, six, ten, and twelve-months post-surgery. Results : Postoperative revival was ordinary with no noteworthy postoperative complications. Wound closure and angiogenesis occurred shortly after day one. New bone formation in all augmented maxillary sinuses was detected alongside the implants on plain radiographs and on conebeam computed tomograms. The patients were highly satisfied (>80%) with the treatment regime and the success rate of the implants was 100% after a usual 10 months loading period. Conclusion : PBM, PES, and CGF promoted angiogenesis and wound healing following lateral wall sinus lift by increasing wound approximation and decreasing bleeding and swelling. Patients recorded less postoperative pain, speech impairment, analgesic use and trismus.

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“…5 . This procedure is of particular relevance to implantology, especially regarding diverse augmentation procedures, unfavorable anatomic conditions (horizontal and vertical augmentation, sinus lift etc.)…”

Section: Fig 5 -Cone-beam Computed Tomography Scan and 3dmentioning

confidence: 99%

Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

Mirković¹,

Djurdjević-Mirković

Pugkar³

2015

VSP

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Therapeutic use of platelet-rich plasma in oral surgery

Cited by 7 publications

References 21 publications

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

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