Therapeutical use of probiotic formulations in clinical practice

Iannitti, Tommaso; Palmieri, Beniamino

doi:10.1016/j.clnu.2010.05.004

Cited by 220 publications

(147 citation statements)

References 106 publications

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“…Thus, during the exercise, IL-6 plays an antiinflammatuar action by elevating, but after the exercise program, the same effect is likely to be obtained by decreased levels. Probiotics are able to develop the mucosal barrier by increasing the production of innate immune molecules and some strains stimulate the adaptive immune responses (Iannitti and Palmieri 2010). Probiotic bacteria of Lactococcus lactis subsp.…”

Section: Discussionmentioning

confidence: 99%

In case of obesity, longevity-related mechanisms lead to anti-inflammation

Kaya

Bayiroğlu

Mıs

et al. 2013

AGE

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The exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model. Experimental obesity was promoted in a total of 32 young (2 months old) and 32 aged (16 months old) male Wistar albino rats through 8-week cafeteria diet (salami, chocolate, chips, and biscuits). Old and young animals were divided into groups each consisting of eight animals and also divided into four subgroups as obese control, obese food restriction, obese probiotic-fed and obese exercise groups. Probiotic group diet contained 0.05 %w/total diet inactive and lyophilized Lactobacillus casei str. Shirota. The exercise group was subjected to treadmill running 1 h/day, at 21 m/min and at an uphill incline of 15 % for 5 days a week. Food restriction group was formed by giving 40 % less food than the others. The control group was fed regular pellet feed ad libitum. This program was continued for 16 weeks. Blood samples from all the groups were analyzed for fasting glucose, insulin, IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3), interleukin (IL)-6, IL-12, malondialdehyde (MDA), fT3, TT3, fT4, TT4, and liver tissue MDA levels were measured. All applications showed anti-inflammatory effects through the observed changes in the levels of IGFBP-3, IL-6, and IL-12 in the young and old obese rats. While the interventions normally contribute to longevity by recruiting different action mechanisms, anti-inflammatory effect is the only mode of action for all the applications in the obesity model.

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Section: Discussionmentioning

confidence: 99%

In case of obesity, longevity-related mechanisms lead to anti-inflammation

Kaya

Bayiroğlu

Mıs

et al. 2013

AGE

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“…Moreover, Lactococcus, Streptococcus, Enterococcus, nonpathogenic strains of Escherichia coli, and certain bacilli and yeast strains such as Saccharomyces boulardii can also have probiotic activity; thus, they are considered probiotic-like microorganism (Howarth & Wang, 2013;Iannitti & Palmieri, 2010;Magalhães et al, 2011a). They are different from probiotics in that they are not found in the gastrointestinal tract of the host (Magalhães et al, 2011a).…”

Section: Probioticsmentioning

confidence: 99%

Labneh with probiotic properties produced from kefir: development and sensory evaluation

Rocha¹,

Martins²,

Santos³

et al. 2014

Food Sci. Technol (Campinas)

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The labneh or labaneh is a popular fermented milk in the Middle East. Another fermented product that deserves special mention is kefir since it has probiotic activity and unique sensory, nutritional, and therapeutic properties. The aim of the present study was to develop a functional probiotic labneh using kefir as a fermenting agent and to perform a sensory analysis of the obtained product. Kefir was obtained by growing grains in pasteurized milk. Samples of skimmed and whole labneh were prepared from the inoculation of 5% kefir milk (skimmed/whole) at 28 °C for 24h, followed by cooling (12-18h) and whey drainage (12-24h), both at 4 °C. Sensory analysis was performed with 70 untrained panelists using a 9-point scale hedonic in the acceptance tests. The paired t-test was used to compare the differences between the means of the scores obtained, with the significance level of 5%. The labneh prepared showed good acceptance by the judges, and the whole labneh samples had the highest scores in the acceptance test. Further studies on the analysis of microbiological viability, nutritional composition, and determination of shelf life, also to improve acceptability of the low-fat version of the product, are needed.

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“…10 6 cfu/ml regard to recommendation that probiotic concentrations must be greater than or equal to 10 6 cfu/ml in the small intestine and 10 8 cfu/g in the colon (Aureli et al, 2011, Collins et al, 1998. Recent data, a dose of 5 billion cfu (5 × 10 9 cfu/day) at least 5 days has been recommended for therapeutical use of probiotic bacteria in clinical practice (Iannitti and Palmieri, 2010). The results showed considerable variability in both dietary groups regardless the age of probands (Fig.…”

Section: Surviving Of Lactic Acid Bacteria At Low Phmentioning

confidence: 99%

Testing of selected probiotic properties of lactic acid bacteria isolated from vegetarians and meat-eaters faeces

Hybenová

Bírošová

Nagyová

et al. 2014

Acta Chimica Slovaca

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The aim of this work was to evaluate presence and properties of lactic acid bacteria in the faeces of 240 volunteers with various nutrition habits (vegetarians versus meat-eaters). Lactic acid bacteria counts in all age groups were nearly 5 or 6 logarithmic orders. Significantly higher amounts were found in women. Subsequently, based on the age and dietary pattern of probands, four samples were selected for isolation of lactic acid bacteria and identification of isolates in order to assign them to bacterial species. About 80 lactic acid bacteria were isolated from the faeces of young (21-30 years) and older (51-60 years) vegetarians and meateaters. The identification of the isolates was based on their morphological and biochemical characteristics. Isolates belong to lactobacilli, bifidobacteria, enterococci and propionibacteria. Surprisingly, bifidobacteria were predominated in older age group. The following probiotic properties were determined: survival at low pH value, and bile salt hydrolase activity. All strains were negative in bile salt hydrolase activity, but their growth was not inhibited in the presence of bile. The results from the study of survival at low pH value showed considerable variability in both dietary groups regardless the age of probands. However, it can be concluded, that bacteria isolated from the samples of older probands were more sensitive to acid pH.

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Therapeutical use of probiotic formulations in clinical practice

Abstract: Further future clinical trials, involving large numbers of patients, will be mandatory to achieve definite evidence of the preventive and curative role of probiotics in medical practice.

Cited by 220 publications

References 106 publications

In case of obesity, longevity-related mechanisms lead to anti-inflammation

In case of obesity, longevity-related mechanisms lead to anti-inflammation

Labneh with probiotic properties produced from kefir: development and sensory evaluation

Testing of selected probiotic properties of lactic acid bacteria isolated from vegetarians and meat-eaters faeces

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