2010
DOI: 10.1128/aac.01267-09
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Therapy of Murine Pulmonary Aspergillosis with Antibody-Alliinase Conjugates and Alliin

Abstract: Aspergillus fumigatus is an opportunistic fungal pathogen responsible for invasive aspergillosis in immunocompromised individuals. The high morbidity and mortality rates as well as the poor efficacy of antifungal agents remain major clinical concerns. Allicin (diallyl-dithiosulfinate), which is produced by the garlic enzyme alliinase from the harmless substrate alliin, has been shown to have wide-range antifungal specificity. A monoclonal antibody (MAb) against A. fumigatus was produced and chemically ligated … Show more

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Cited by 30 publications
(24 citation statements)
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“…The latter is known to have serious post infection consequences [24] . The plants are also used as anti mycotic and anti-cancer agents [25,26] . The ultimate aim will be the purification and concentration of the active ingredients of both plants as drugs against susceptible organisms.…”
Section: Discussionmentioning
confidence: 99%
“…The latter is known to have serious post infection consequences [24] . The plants are also used as anti mycotic and anti-cancer agents [25,26] . The ultimate aim will be the purification and concentration of the active ingredients of both plants as drugs against susceptible organisms.…”
Section: Discussionmentioning
confidence: 99%
“…Targeting is achieved by conjugating the enzyme to site-specific antibodies. Such conjugates produced pronounced therapeutic effects in experimental animals bearing various types of tumor [15][16][17] or suffering from pulmonary aspergillosis [18] when injected prior to administration of alliin.…”
Section: Stabilization Of Alliinase From Garlic By Osmolytes and The mentioning
confidence: 99%
“…fumigatus activities in vitro [80]. In a murine pulmonary aspergillosis model, A. fumigatus-specific IgM MAb-alliinase conjugate enhanced survival of immunosuppressed mice by causing specific killing of A. fumigatus without damaging the lung tissue [81].…”
Section: Demonstration Of Protective Role Of Antibodies In Fungal Infmentioning
confidence: 99%