Thermosensitive Ferromagnetic Implant for Hyperthermia Using a Mixture of Magnetic Micro-/Nanoparticles

Tonthat, Loi; Yamamoto, Yoshiyuki; Aki, Fumitaka; Saito, Hajime; Mitobe, Kazutaka

doi:10.1109/tmag.2018.2820061

Cited by 12 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the constructed system, the heating temperature was accurately controlled in vitro with a very small standard deviation temperature at steady state, overshoot, rise time, and settling time. Further studies are to optimize the developed system to achieve further improvements, validate it in vivo , and then attempt to develop a noninvasive temperature control system using our previously‐developed thermosensitive magnetic particles [11] as an alternative to the fiber optic thermometer.…”

Section: Discussionmentioning

confidence: 99%

A Simple and High‐Accuracy PID‐Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer

Shikano

Tonthat

Yabukami

2021

IEEJ Transactions Elec Engng

Self Cite

View full text Add to dashboard Cite

Magnetic hyperthermia is very promising cancer therapy in which heating temperature is expected to be a key determinant for its success. Herein, we present a simple, real-time, and high-accuracy proportional-integral-derivative-based temperature control system for magnetic hyperthermia using widely-used induction heater and fiber optic thermometer. Our in vitro result shows that the temperature of clinically-approved Resovist ® (0.5 ml) was accurately controlled with very small overshoot (e.g., 45.0 ± 0.07 • C and 55.0 ± 0.11 • C for low-and high-temperature magnetic hyperthermia). Our system has the potential to be used for magnetic hyperthermia either alone or together with other cancer treatment modalities for basic and clinical studies.

show abstract

Section: Discussionmentioning

confidence: 99%

A Simple and High‐Accuracy PID‐Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer

Shikano

Tonthat

Yabukami

2021

IEEJ Transactions Elec Engng

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is a liquid suspension consisting of superparamagnetic nanoparticles (maghemite, γ‐Fe 2 O 3 ) coated with carboxydextran, and the concentration of the nanoparticles is 39.9 mg/ml. The average particle size of the nanoparticles was 3.6 nm by measuring more than 200 particles from the images captured with a transmission electron microscopy (JEM‐2010, JEOL, Tokyo, Japan) . The total mass of the nanoparticles in the sample (0.3 ml of Resovist®) was 0.012 g.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Magnetic heating experiments were performed using a laboratory‐made experimental setup as shown in Fig. . Our setup was designed similar to the measurement systems found in the literature for evaluating heating and ac magnetization properties of magnetic particles.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Among the magnetic materials for biomedical applications, superparamagnetic nanoparticles have been gaining more attention due to their potential as not only therapeutic agents for magnetic hyperthermia but also as diagnostic agents for magnetic particle imaging, which has been proposed to visualize the spatial distribution of superparamagnetic nanoparticles recently . So far, a MRI contrast agent named Resovist® that is clinically approved for human use has been widely used to evaluate magnetic hyperthermia and/or magnetic particle imaging applications . To the best of our knowledge, there is little or no information on its heating property dependence on the applied magnetic field.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic field dependence of heating property of resovist® for magnetic hyperthermia

Tonthat

Yamamoto

Aki

et al. 2018

IEEJ Transactions Elec Engng

Self Cite

View full text Add to dashboard Cite

Resovist ® , a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H = 1.8-7.1 kA/m, f = 500 kHz, and H = 4.8 kA/m, f = 200-1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g at H = 7.1 kA/m, f = 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist ® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist ® required for treatment.

show abstract

“…In most cases, magnetic nanoparticles are added into the target tissue as well to increase the induction of heat. Can use hyperthermia treatment in combination with other forms of treatment for better performance [8,9]. In the past year, people have designed the magnets for magnetic hyperthermia applications in large models.…”

Section: Introductionmentioning

confidence: 99%

Analysis of High-Frequency C-Core Magnetic Flux Leakages for Bone Tumor With Induction Heating by Using Multi-Coil

Jokpudsa

Kotchapradit²,

Thongsopa³

et al. 2019

Proceedings 17th International Conference on Microwave and High Frequency Heating

View full text Add to dashboard Cite

High-frequency magnetic field has been developed pervasively. The induction of heat from the magnetic field can help to treat tumor tissue to a certain extent. Normally, treatment by the low-frequency magnetic field needed to be combined with magnetic substances. To assist in the induction of magnetic fields and reduce flux leakage. However, there are studies that have found that high frequencies can cause heat to tumor tissue. In this paper present, a new magnetic application will focus on the analysis of the high-frequency magnetic nickel core with multi-coil. In order to focus the heat energy using a high-frequency magnetic field into the tumor tissue. The magnetic coil was excited by 915 MHz signal and the combination of tissues used are muscle, bone, and tumor. The magnetic power on the heating predicted by the analytical model, the power loss density (2.98e-6 w/m3) was analyzed using the CST microwave studio.

show abstract

Thermosensitive Ferromagnetic Implant for Hyperthermia Using a Mixture of Magnetic Micro-/Nanoparticles

Cited by 12 publications

References 28 publications

A Simple and High‐Accuracy PID‐Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer

A Simple and High‐Accuracy PID‐Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer

Magnetic field dependence of heating property of resovist® for magnetic hyperthermia

Analysis of High-Frequency C-Core Magnetic Flux Leakages for Bone Tumor With Induction Heating by Using Multi-Coil

Contact Info

Product

Resources

About