Thermospray liquid chromatography-mass spectrometry for the characterization of sulphate ester conjugates

Bowers, Gary; Higton, David; Manchee, Gary R.; Oxford, Janet; Saynor, D. A.

doi:10.1016/s0021-9673(01)88447-8

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…Conventional HPLC flow rates (1-2 mL/min) were accommodated by this interface, using volatile buffers that contain ammonium acetate. New applications were realized, and higher standards of analytical performance were established for pharmaceutical analysis (Voyksner et al, 1985;Beattie and Blake, 1989;Oxford and Lant, 1989;Malcolm et al, 1990;Bowers et al, 1991).…”

Section: Lc/ms Interfacementioning

confidence: 99%

LC/MS applications in drug development

Lee¹,

Kerns²

1999

Mass Spectrom. Rev.

385

297

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At many times during this project I found myself asking the question,"Why am I doing this?" In my attempt to answer, I would always seem to recount my positive experiences with the analytical sciences. Thus, I feel compelled to give thanks to those who were integral to my education in the analytical sciences and inspirations to my professional development. First, I thank the University of Maryland for encouraging me to pursue an education in the sciences. Second, I thank the graduate program at the University of Florida for providing me an opportunity to focus in the analytical sciences and teaching me how to formulate question and thought. Third, I thank Bristol-Myers Squibb for balancing my hunger for the application of analytical sciences with the need to experience collaboration, interaction, and growth. To each of the above mentioned institutions, I am grateful for the support and continued source of inspiration. To all the people at the above mentioned institutions, I will hold dear the friendships, relationships, and memories that are the result of success and failure. And finally, I wish to thank my loving wife and family for their continual encouragement and support for everything I do. For this, I am truly blessed. xii ACKNOWLEDGMENTS CHAPTER 1 1

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Section: Lc/ms Interfacementioning

confidence: 99%

LC/MS applications in drug development

Lee¹,

Kerns²

1999

Mass Spectrom. Rev.

385

297

View full text Add to dashboard Cite

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Letter to the editors

1992

Biol. Mass Spectrom.

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Umespirone (KC-9172) is a new agent currently under development for the treatment of chronic psychosis and anxiety disorders', the structure of which we proved by EIMS and NMR investigations'. KC-S172 (UMESPIRONE)For studies on the metabolism of KC-9172 male Sprague Dawley CD rats were given 100 mg/kg of the I4C labelled drug in a volume of 4 ml/kg (aqueous suspension in tylose) p. 0. by gavage. The pooled urine was incubated with a mixture of fl-glucuronidase/arylsulphatase, and the urinary metabolites were isolated by direct HPLC of the urine samples on ODs-Hypersil-C-18 with radioactivity detection.

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Bioanalysis of β2-agonists by hyphenated chromatographic and mass spectrometric techniques

Polettini¹

1996

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Thermospray liquid chromatography-mass spectrometry for the characterization of sulphate ester conjugates

Cited by 6 publications

References 3 publications

LC/MS applications in drug development

LC/MS applications in drug development

Letter to the editors

Bioanalysis of β2-agonists by hyphenated chromatographic and mass spectrometric techniques

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