ABSTRACT.A study was performed to investigate the experimental conditions and systematic uncertainties that need to be considered in order to precisely characterize quantum efficiency (QE). Measurements were performed on a HAWAII-2RG1:7 μm detector but the methodology of characterization is applicable to other detectors as well and may be useful in characterization of detectors used in future ground and space based surveys. For this study the detector QE as a function of illumination intensity, total integrated signal, and temperature was measured. A 3% relative systematic uncertainty on the measured QE value was achieved at wavelengths longer than 800 nm but the total uncertainty in the determination of absolute QE is dominated by the uncertainty in the conversion gain, which adds an additional 3.4% scale uncertainty. It was found that the measured detector QE depends on illumination intensity and that temperature dependence of QE can, at least in part, be attributed to reciprocity failure. Well-chosen detector bias voltages can reduce integrated signal nonlinearity.