Three new Cu(II) and Cd(II) complexes with 3-(2-pyridyl)pyrazole-based ligand: Syntheses, crystal structures, and evaluations for bioactivities

Chen, Ran; Liu, Chun‐Sen; Zhang, Hang; Guo, Yue; Bu, Xian‐He; Yang, Ming

doi:10.1016/j.jinorgbio.2006.11.001

Cited by 53 publications

(12 citation statements)

References 45 publications

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“…192 Also the related complex (6c) was evaluated against six different cancer cell lines (HL-60 human leukemic cells, PC-3M-1E8 human prostate tumor cells, BGC-832 cells, MDA cells, Bel-7402 human hepatoma cells, and Hela human cervix cancer cells) showing considerable inhibitory rate and cytotoxic specificity. 193 The 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene ligand and the corresponding metal complexes have an extended aromatic p-system (like those shown by typical bidentate chelating ligands (bipy) and 1,10-phenanthroline (phen)) and they bound to DNA by intercalation mode showing a marked DNA-cleavage activity. 192 More recently, Padhye et al 194 have described the synthesis of the bis(3,6-pyrazol-1-yl)pyridazine ligand and of the related Cu(II) complex (6d).…”

Section: Copper Complexes With Imidazoles and Related Ligandsmentioning

confidence: 99%

Copper in diseases and treatments, and copper‐based anticancer strategies

Tisato¹,

Marzano

Porchia³

et al. 2009

Medicinal Research Reviews

671

420

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Copper is found in all living organisms and is a crucial trace element in redox chemistry, growth and development. It is important for the function of several enzymes and proteins involved in energy metabolism, respiration, and DNA synthesis, notably cytochrome oxidase, superoxide dismutase, ascorbate oxidase, and tyrosinase. The major functions of copper-biological molecules involve oxidation-reduction reactions in which they react directly with molecular oxygen to produce free radicals. Therefore, copper requires tightly regulated homeostatic mechanisms to ensure adequate supplies without any toxic effects. Overload or deficiency of copper is associated, respectively, with Wilson disease (WD) and Menkes disease (MD), which are of genetic origin. Researches on Menkes and Wilson disorders have provided useful insights in the field of copper homeostasis and in particular into the understanding of intracellular trafficking and distribution of copper at molecular levels. Therapies based on metal supplementation with copper histidine or removal of copper excess by means of specific copper chelators are currently effective in treating MD and WD, respectively. Copper chelation therapy is now attracting much attention for the investigation and treatment of various neurodegenerative disorders such as Alzheimer, Parkinson and CreutzfeldtJakob. An excess of copper appears to be an essential co-factor for angiogenesis. Moreover, elevated levels of copper have been found in many types of human cancers, including prostate, breast, colon, lung, and brain. On these basis, the employment of copper chelators has been reported to be of therapeutic value in the treatment of several types of cancers as anti-angiogenic molecules. More recently, mixtures of copper chelators with copper salts have been found to act as efficient proteasome inhibitors and apoptosis inducers, specifically in cancer cells. Moreover, following the worldwide success of platinum(II) compounds in cancer chemotherapy, several families of individual copper complexes have been studied as potential antitumor agents. These investigations, revealing the occurrence of mechanisms of action quite different from platinum drugs, head toward the development of new anticancer metallodrugs with improved specificity and decreased toxic side effects.

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Section: Copper Complexes With Imidazoles and Related Ligandsmentioning

confidence: 99%

Copper in diseases and treatments, and copper‐based anticancer strategies

Tisato¹,

Marzano

Porchia³

et al. 2009

Medicinal Research Reviews

671

420

View full text Add to dashboard Cite

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“…As shown in Figure 6B [64]. Some studies have reported that the nanoparticle toxicity varies with different cell lines [68,69]. But, such fact has not been fully understood.…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Cytotoxicity assessment of functionalized CdSe, CdTe and InP quantum dots in two human cancer cell models

Liu

et al. 2015

Materials Science and Engineering: C

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“…Its activity was also confirmed against other cell lines, including prostate cancer PC-3M-1E8, hepatoma cells Bel-7402, and cervical cancer HeLa). The cytotoxic properties were associated with the ability to intercalate and generate DNA breaks [ 93 ].…”

Section: Interaction Of Metal Complexes With Dnamentioning

confidence: 99%

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

2020

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Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.

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Three new Cu(II) and Cd(II) complexes with 3-(2-pyridyl)pyrazole-based ligand: Syntheses, crystal structures, and evaluations for bioactivities

Cited by 53 publications

References 45 publications

Copper in diseases and treatments, and copper‐based anticancer strategies

Copper in diseases and treatments, and copper‐based anticancer strategies

Cytotoxicity assessment of functionalized CdSe, CdTe and InP quantum dots in two human cancer cell models

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

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