Titania-coated 2D gold nanoplates as nanoagents for synergistic photothermal/sonodynamic therapy in the second near-infrared window

Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…Transition metal oxide (TMO) semiconductor nanomaterials have been attracting great attention in recent years owing to superior biocompatibility, easy preparation and flexibly tailored localized surface plasmon resonance (LSPR) effect [21,22]. Especially, more interest has been focused on the broadband absorbing TMOs and their derivatives for NIR-II PTT [23][24][25]. However, most of the reported TMOs suffer from relatively low photothermal conversion efficiencies (PTCEs) in NIR-II region.…”

Section: Introductionmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

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Research on deep-tissue photothermal therapy (PTT) in the near-infrared II (NIR-II, 1000-1350 nm) region has bloomed in recent years, owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I (NIR-I, 650-950 nm) region. However, more details need to be uncovered to facilitate a fundamental understanding of NIR-II PTT. Herein, a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide (MoO 2) nanoaggregates was fabricated. The photothermal conversion capabilities of MoO 2 in the NIR-I and II regions were investigated step by step, from a simple tissue phantom to a three-dimensional cellular system, and further to a tumor-bearing animal model. NIR-II laser exhibited a lower photothermal attenuation coefficient (0.541 at 1064 nm) in a tissue phantom compared with its counterpart (0.959 at 808 nm), which allows it to be more capable of deeptissue PTT in vitro and in vivo. Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth. Moreover, the depth-related tumor ablation was also studied by Raman fingerprint analysis, which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues, providing fundamental knowledge to NIR-II deeptissue photothermal therapy.

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“…These combinational therapy strategies for tumors showed obviously higher efficacy than the individual treatment in all the examples. Besides, Au nanoplates coated by a TiO 2 shell (Au NPL@TiO 2 ) was synthesized by Zhang and co‐workers to conduct NIR‐II PTT with the assistance of sonodynamic therapy (SDT) . SDT is a treatment modality to generate toxic reactive oxygen species (ROS) triggered by ultrasound for cell killing.…”

Section: Nir‐ii Pttmentioning

confidence: 99%

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

2019

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Photoacoustic (PA) imaging and photothermal therapy (PTT) provide useful tools for diagnosis and treatments of diseases. However, current applications of PA imaging and PTT are greatly limited by their relying on light source in the first near‐infrared (NIR) window (NIR‐I, 750–1000 nm), which shows shallow tissue penetration depth. Recently, this predicament is addressed by the use of second NIR (NIR‐II) light ranging from 1000 to 1700 nm due to reduced light–tissue interaction and increased allowable power density for light irradiation. Since a few endogenous biomolecules can absorb or emit NIR‐II light, it is necessary to develop contrast and therapeutic agents used for PA imaging and PTT in the NIR‐II window. This review summarizes the recent progresses of NIR‐II absorbing optical agents for PA imaging and PTT in living animal models. The prominent performance of NIR‐II PA imaging and NIR‐II PTT is first introduced with the use of optical agents, followed by discussion of the applications of NIR‐II PTT under the guidance of NIR‐I or NIR‐II PA imaging. At last, challenges and perspectives of NIR‐II absorbing optical agents for PA imaging and PTT are proposed.

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Titania-coated 2D gold nanoplates as nanoagents for synergistic photothermal/sonodynamic therapy in the second near-infrared window

Abstract: Au NPL@TiO2 nanostructures play the dual role of heat- and ROS-generating agents, which lead to synergetic photothermal/sonodynamic therapy in the second biological window.

Cited by 144 publications

References 41 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

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