To Study the Morphological Changes Seen in Stored Blood in a Blood Bank

Abstract

BACKGROUNDThe viability and functionality of stored human blood cells is an important clinical issue in transfusion. 1 During storage, in fact preserved blood cells undergo progressive structural and functional changes that may reduce red cell function and viability a fter transfusion. 2 Storage has a negative effect on RBC oxygen delivery 3 and emerging evidence suggests that allogenic RBC infusion may actually harm some recipients. Considerable evidence suggests that transfusion increases the risk of serious complications and death in critically ill patients, especially in patients who are undergoing cardiac surgery. Current research indicated that the RBC storage lesion is responsible for impaired tissue oxygen use, pro-inflammatory and immunomodulatory effects, increased infections, multiple organ system failure and ultimately increased morbidity and mortality. 4 The aim of present study was to evaluate the morphological changes in blood cells due to processing and storage at interval of 1 day, 1 week, 2 weeks, 3 weeks, 4 weeks and 5 weeks and compare with the morphology at the time of collection (day 0).

A Comparative Study of Storage Related Haematological Changes in Whole Blood and PRBC in Blood Bank of a Tertiary Care Hospital

“…Considering that Chabbra S et al (2017) included eligible donors for blood donation belonged to 18-25 age group (47%) followed age group of 26-30 years (23%). [15] Only 2 of the donors were female. While study conducted by Verma M et al (2015) in 30 donors 25 were males and 5 were females.…”

“…Also changes in WBC and platelet occur with storage. [15] Storage Related Changes in RBC Preservation and long term storage of Red Blood Cells (RBCs) is needed to ensure a readily available, safe blood supply for transfusion medicine. Storage has a negative effect on RBC oxygen delivery and emerging evidence suggests that allogenic RBC infusion may actually harm some recipients.…”

“…Reported that the non-significant changes in RBC indices on long storage. [16] Effect of Storage on lymphocytes and granulocytes Gupta P et al (2016) reported that no change in lymphocytes is seen. [15] Whereas in present study the mean lymphocytes count at decreases from first day to thirty fifth day.…”

“…[16] Effect of Storage on lymphocytes and granulocytes Gupta P et al (2016) reported that no change in lymphocytes is seen. [15] Whereas in present study the mean lymphocytes count at decreases from first day to thirty fifth day. Although, percentage of lymphocytes increases.…”

Some Studies on Red Blood Cells Morphology of Healthy and Diabetic Patients in Taiz, Yemen

“…Echinocytes were also occasionally encountered. Gupta et al, [81] recorded that with storage percentage, the discocytes decreased and that echinocytes and spherocytes increased. Blasi et al, [82] stated that significant alterations to RBC morphology over storage duration occur soon after the 14th day of storage, as to become significant enough within the 21st day.…”