Tocotrienol rich fraction supplementation confers protection on the ovary from cyclophasphamide induced apoptosis

Salleh, Hazar Shakir; Omar, Effat; Froemming, Gabriele Ruth Anisah; Said, Rozzana Mohd

doi:10.1016/s2222-1808(14)60532-6

Cited by 7 publications

(2 citation statements)

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“…Moreover, as reported in more recent findings, using co-incubation in media supplemented with γ-TCT and hydrogen peroxide (H 2 O 2 ), γ-TCT improved the development of porcine embryos through modulation of the apoptotic BCL-XL and BAX genes [ 135 ]. The beneficial effects of TCTs were also supported by the reports on the concomitant supplementation of TRF with the anti-cancer prodrug, cyclophosphamide (CPA) on ovarian cells, which was reported to provide protection against OS-induced apoptosis in the ovaries [ 132 , 133 ].…”

Section: Antioxidants and Their Roles In Reproductive Disordersmentioning

confidence: 89%

“…Following the first publication by Evans and Bishop [ 1 ], a later report discussed the role of vitamin E in reproduction after observations in which a vitamin-E deficient diet resulted in uterine discolorations in rats [ 128 ]. Decades later, research on the role of vitamin E in reproductive physiology was re-initiated, and it was reported to have beneficial effects against stress-induced oxidative stress (OS) [ 129 , 130 , 131 , 132 , 133 ].…”

Section: Antioxidants and Their Roles In Reproductive Disordersmentioning

confidence: 99%

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Vitamin E as an Antioxidant in Female Reproductive Health

2018

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Vitamin E was first discovered in 1922 as a substance necessary for reproduction. Following this discovery, vitamin E was extensively studied, and it has become widely known as a powerful lipid-soluble antioxidant. There has been increasing interest in the role of vitamin E as an antioxidant, as it has been discovered to lower body cholesterol levels and act as an anticancer agent. Numerous studies have reported that vitamin E exhibits anti-proliferative, anti-survival, pro-apoptotic, and anti-angiogenic effects in cancer, as well as anti-inflammatory activities. There are various reports on the benefits of vitamin E on health in general. However, despite it being initially discovered as a vitamin necessary for reproduction, to date, studies relating to its effects in this area are lacking. Hence, this paper was written with the intention of providing a review of the known roles of vitamin E as an antioxidant in female reproductive health.

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Section: Antioxidants and Their Roles In Reproductive Disordersmentioning

confidence: 89%