Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice

Abstract

This study aimed to assess the possible topical antinociceptive activity of Vanillosmopsis arborea Baker essential oil (EOVA) and to clarify the underlying mechanism, using the acute model of chemical (eye wiping) nociception in mice. EOVA (25 to 200 mg/kg; p.o. and topical) evidenced significant antinociception against chemogenic pain in the test model of formalin-induced neuroinflammatory pain. Local application of 5 M NaCl solution on the corneal surface of the eye produced a significant nociceptive behavior, characterized by eye wiping. The number of eye wipes was counted during the first 30 s. EOVA (25, 50, 100, and 200 mg/kg; p.o. and topical) significantly decreased the number of eye wipes. Naloxone, yohimbine, L-NAME, theophylline, glibenclamide, and ruthenium red had no effect on the antinociceptive effect of EOVA. However, ondansetron, p-chlorophenylalanine methyl ester (PCPA), capsazepine, prazosin, and atropine prevented the antinociception induced by EOVA. These results indicate the topical antinociceptive effect of EOVA and showed that 5-HT, α1, TRPV1, and central muscarinic receptors might be involved in the antinociceptive effect of EOVA in the acute corneal model of pain in mice.

Analgesic Potential of Essential Oils

“…The topical antinociceptive effect of Vanillosmopsis arborea Baker essential oil (25, 50, 100 and 200 mg/Kg, p.o. or topical) was studied by Leite et al [52] in mice subjected to formalin and eye wiping (corneal nociception) tests. The composition ( w / w ) of Vanillosmopsis arborea Baker essential oil revealed the presence of α-bisabolol (70%).…”

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

“…a-Bisabolol (Table 5, ID 03) is a monocyclic sesquiterpene extracted from the essential oils of various plants, mainly the flowers of Matricaria chamomilla and the bark of Vanillosmopsis arborea Baker (Kamatou and Viljoen, 2010;Inocencio Leite et al, 2014). Several biological effects have been described for abisabolol including neuroprotective (Fernandes et al, 2019), antiparasitic (de , anticancer (Wu et al, 2018), and antibacterial activity (de Sousa .…”

Antinociceptive and anti-inflammatory effects of hydrazone derivatives and their possible mechanism of action in mice

“…), naloxone (1.5 mg/kg, i.p. ), N (G)-Nitro- L -arginine methyl ester ( L -NAME, 20 mg/kg, i.p), and ondansetron (0.5 mg/kg, i.p) [ 14 , 22 ]. Then, the total licking and/or biting time was measured as described above.…”