Topical isoflavones provide effective photoprotection to skin

Lin, Jingyi; Tournas, Joshua A.; Burch, James A.; Monteiro‐Riviere, Nancy A.; Zielinski, Jan E.

doi:10.1111/j.1600-0781.2008.00329.x

Cited by 60 publications

(37 citation statements)

References 41 publications

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“…FA can be used as an additive in sunscreens available on the market to increase photoprotection of the skin, hair and combat premature and natural aging according to studies conducted by Lin et al (2008). Pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C, 1% vitamin E and 0.5% FA daily for 4 days.…”

Section: Uv Protection Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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Section: Uv Protection Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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“…In animal model, topical application of equol before solar simulated ultraviolet irradiation offers protection against the formation of UV induced cyclobutane pyrimidine dimers, formation of sunburn cell and erythema (Widyarini, 2006;Lin et al, 2008). However, the protection was less than that of other flavonoids, such as its precursor daidzein or genistein.…”

Section: Isoflavonesmentioning

confidence: 94%

“…UV radiation exerts its immunosuppressive effects in several different ways by (i) inhibiting the function of antigen-presenting cells, (ii) inducing T cells with suppressor activity, and (iii) causing the release of immunosuppressive cytokines (Schwarz et al, 2002). IL-10 appears to be a key mediator of UV radiation-induced immunosuppression (Loser et al, 2007). In contrast to the effects of IL-10, interleukin-12 (IL-12) prevents UVB radiation-induced local immunosuppression (Schwarz et al, 1996).…”

Section: * Corresponding Authormentioning

confidence: 99%

Photoprotection of natural flavonoids

Saewan

Jimtaisong²

2013

J App Pharm Sci

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Overexposure to ultraviolet (UV) radiation can cause a number of skin disorders such as erythema, edema, hyperpigmentation, immunosuppression, photoaging, and skin cancer. Since the level of UV radiation is increasing as a result of depletion of the stratospheric ozone and climate change, the protection of human skin against the harmful effects of UV radiation is an urgent need. Topical application of sunscreens is a strategy to protect the deleterious effect of UV radiation on the skin. Sunscreens today contain one or several synthetic UV filter molecules which protect the UV radiation exposed on the epidermis. These molecules are broadly divided into physical and chemical agents. Physical sunscreens reflect and scatter UVB, UVA and visible radiation. Chemical sunscreens act by absorbing ultraviolet radiation and re-emitting chemical energy as heat or light. Several synthetic UV filter molecules are available in the market but they have limited use because these active molecules may create adverse effects on human skin. Some information on possible photon induced reaction such as photoirritation, photosensitization and contact dermatitis by sunscreen products containing synthetic organic sunscreen agents. To overcome these side effects, naturally occurring compounds have gained considerable attention as photoprotective agents. Flavonoids, a group of natural occurring compounds, act as catalysts in the light phase of photosynthesis and as stress protectants in plant cells by scavenging reactive oxygen species (ROS). Natural flavonoids have the potential photoprotection because of their UV absorbing, their ability to act as direct and indirect antioxidants as well as anti-inflammatory and immunomodulatory agents which provide exciting platforms for the development of photoprotection. This review summarizes the structure and potential photoprotection activity of several natural flavonoids.

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“…Among the polyphenols found in our extract, efficacy of fumaric acid was depicted in psoriasis [15,16]. In various clinical studies ferulic acid was found to have protective effects against damage caused by the UV irradiation and chemically induced skin tumorigenesis [17][18][19]. Ferulic acid and sinapic acid analogues were reported to inhibit UVA induced oxidative stress in skin [20].…”

Section: Gene Expression Analysis (Real-time Qpcr)mentioning

confidence: 99%

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

Türkoğlu¹,

Kılıç²,

Pekmezci³

et al. 2018

Rec.Nat.Prod.

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Lepidium sativum L. (Brassicaceae) (Ls), garden cress, is an edible herb that is botanically related to watercress and mustard, sharing their peppery, tangy flavor and aroma. The various parts of the plant have been traditionally used for many respiratory, rheumatologic, cardiovasculary, metabolic, and gastrointestinal disorders. Several studies were performed showing its antiinflammatory, anticarcinogenic, antiproliferative as well as tissue protective effects. In all of these studies the positive effects of Ls were concluded as the result of its antioxidant features due to the polyphenols and organosulphur compounds. In this study, we investigated the molecular basis of antiinflammatory, antiproliferative, antimitotic and antiandrogenic effects of Ls leaf extract in HaCaT cells. The gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factoralpha (TNF-α), interleukin 1-alpha (IL-1α), and 5 alpha-reductase type II (SRD5A2) were studied. Gene expressions were determined by RT-qPCR analysis. Fold change results of the gene expression analyses showed that the plant extract caused statistically significant downregulation of VEGF (0.2167, p<0.0001), p = 0.0262), and SRD5A2 (0.0567, p<0.0001). The fold change for IL-1α was 0.6900 and this result was not statistically significant (p = 0.1522). These preliminary results may partially explain the clinical success of Ls in the traditional medicine. Considering these results, topical application of Lepidium sativum extract may be beneficial for inflammatory, androgen dependent disorders of the skin.

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Topical isoflavones provide effective photoprotection to skin

Abstract: Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage.

Cited by 60 publications

References 41 publications

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Photoprotection of natural flavonoids

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

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