Tough hydrogel with high water content and ordered fibrous structures as an artificial human ligament

Abstract

Natural biological tissues such as ligaments, due to their anisotropic across scale structure, have high water content, while still maintaining high strength and flexibility. Hydrogels are ideal artificial materials like...

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

“…In addition, the inherent absorbability, high porosity, and stable physical structure of hydrogels provide a favorable environment for wound healing. [17][18][19] Nevertheless, due to the permeability of the barrier, antibiotics as part of the treatment, still have an inevitable impact on the biological activity of probiotics.…”

Biomimetic Mineralization: From Microscopic to Macroscopic Materials and Their Biomedical Applications

“…Hydrogels exhibited great potential in biological applications, such as tissue engineering and drug delivery. − However, traditional hydrogels lack adequate mechanical strength under high water content, limiting their practical application. , Although many methods have been developed to enhance the mechanical properties of hydrogels, the modulus and stiffness of synthetic hydrogels cannot compete with natural hydrogels, such as cartilage. − To address the growing demand for tissue repair applications, a series of hydrogel–mineral composites have been fabricated to enhance the mechanical properties. Gong’s group fabricated a novel tough hydrogel via in situ mineralization .…”

Bionic ordered structured hydrogels: structure types, design strategies, optimization mechanism of mechanical properties and applications

“…115 1D nanomaterials. Nanowires (hydroxyapatite (HAP) nanowires), 36 nanotubes (carbon nanotubes (CNTs)), 117 and nanofibers (cellulose nanocrystals (CNCs), 118 cellulose nanoprimary fibers (CNFs), 119 and bacterial cellulose (BNC) 39,120 ) are common 1D nanomaterials used in constructing bionic ordered structured hydrogels. Nanowires such as HAP nanowires are highly biocompatible and can be assembled into hierarchical ordered structures, making them popular for constructing highly ordered nanostructures.…”

“…As a human medical implant, it provides effective mechanical support and developmental guidance for tissue growth and new tissue formation. 89,117 For example, the multi-layer gradient structure mimicking bones was implanted into the tissue as an implant for the repair and replacement of cartilage. Following several days of culture, histological examination indicated significant proliferation of somatic cells (Fig.…”