Towards nanoporous polymer thin film-based drug delivery systems

Yan, Wei; Hsiao, Vincent K. S.; Yong, Zheng; Shariff, Yasir M.; Gao, Tieyu; Huang, Tony Jun

doi:10.1016/j.tsf.2008.09.080

Cited by 43 publications

(35 citation statements)

References 59 publications

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“…To administer the drug release in the oral route, drug molecule is generally encapsulated in excipients, which protects the bioactive molecule from enzymatic degradation in gastrointestinal (GI) tract. These excipients can be in various physical forms such as micro/nanoparticles [3][4][5], hydrogels [6,7], thin films [8,9], micelle [10,11], micro/nanogels [12,13] etc. However over the past decade, nanofibers have been demonstrated as potential drug delivery systems due to their large surface area to volume ratio and controllable porosity, thereby resulting high drug loading capacity [14].…”

Section: Introductionmentioning

confidence: 99%

In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

Laha

Yadav

Majumdar

et al. 2016

Biochemical Engineering Journal

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a b s t r a c tDelivering hydrophobic drug within hydrophilic polymer matrix as carrier is usually a challenge. Here we report the synthesis of gelatin nanofibers by electrospinning, followed by testing them as a potential carrier for oral drug delivery system for a model hydrophobic drug, piperine. Electrospun gelatin nanofibers were crosslinked by exposing to saturated glutaraldehyde (GTA) vapor, to improve their water resistive properties. An exposure of only 6 min was not only adequate to control the early degradation with intact fiber morphology, but also significantly marginalized any adverse effects associated with the use of GTA. Scanning electron microscopy imaging, Fourier transform infrared spectroscopy and thermogravimetric analysis were done to study nanofiber morphology, stability of drug and effect of crosslinking. The pH of release medium was also varied as per the gastrointestinal tract for in-vitro drug release study. Results illustrate good compatibility of hydrophobic drug in gelatin nanofibers with promising controlled drug release patterns by varying crosslinking time and pH of release medium.

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Section: Introductionmentioning

confidence: 99%

In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

Laha

Yadav

Majumdar

et al. 2016

Biochemical Engineering Journal

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“…The adsorption rate of CHX was rapid during the initial 20 min, and then constant up to 24 h. This result agreed with Wei Yan et al who studied the loading of drugs into nanoporous polymer thin films. They found that the initial absorbance value increased suddenly and then became constant [21]. Considering all the absorbance values, the thickness and roughness of both films were higher for PDADMAC/Alginate than for PDADMAC /PSSMA.…”

Section: Loaded Chx Into Pemmentioning

confidence: 97%

Activity of Chlorhexidine Gluconate Loaded at Varying Polyelectrolyte Multilayers against Aggregatibacter Actinomycetemcomitans

et al. 2016

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Abtract. Chlorhexidine gluconate (CHX) has a bactericidal effect to Aggregatibacter actinomycetemcomitans (Aa) which causes periodontal disease. Therefore the controlled loading and release of CHX from multilayer thin film is beneficial for the local treatment of periodontitis. This study used ten bilayers of PDADMAC/PSSMA and PDADMAC/AL and loaded CHX into each film. Both un-loaded and loaded thin films were analysed using UV-Vis spectroscopy and AFM. The loaded film was thicker and rougher than the un-loaded film for both PDADMAC/PSSMA and PDADMAC/AL film. The loaded films were released in H2O2 for 24 h, and UV-Vis spectroscopy was measured and compared with the standard calibration curve of CHX. Results indicated that PDADMAC/PSSMA released 0.00052 M and PDADMAC/AL released 0.00071 M respectively. Both the loaded films were tested for toxicity to Aa. Neither film killed all colonies of Aa, however they reduced colony growth by 99% compared to the blank condition.

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“…Rhodamine B (Rh-B) is a fluorescent molecule roughly 1.6 nm in size and has been widely used as a model drug to study the behavior of novel drug delivery systems (Oh et al 2008;Yan et al 2009). Although it has little clinical significance, the convenience of detecting it through fluorescence spectrometry makes it a suitable molecule to evaluate the drug loading performance of porous coatings.…”

Section: Rhodamine B Loading and Releasementioning

confidence: 99%

“…Due to their high surface-area-tovolume ratio, nanoporous polymers show increased adsorption of molecules and, therefore, can be used in drug loading and release. In Yan et al (2009), nanoporous polymer membranes have proven to increase the release of the model drug Rhodamine B by a factor of two compared to their nonporous counterparts .…”

Section: Introductionmentioning

confidence: 99%

Porous polysulfone coatings for enhanced drug delivery

Sivaraman¹,

Kellenberger

Ergeneman³

et al. 2012

Biomed Microdevices

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The synthesis of a porous polysulfone (PSU) coating for use in drug delivery applications is presented. PSU can serve as a functional surface coating for drug delivery vehicles, such as intraocular biomicrorobots. The coatings can be applied using spin coating or dip coating. The porosity is introduced by selectively dissolving calcium carbonate nanoparticles embedded in the bulk polymer. The network of pores thus formed increases by a factor of thirty the amount of Rhodamine B (model drug) that can be loaded and by a factor of fifteen the amount that can be released. The films do not affect cell viability and exhibit poor cell adhesion. The straightforward synthesis and predictability of porosity enables the tuning of the amount of drug that can be loaded.

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Towards nanoporous polymer thin film-based drug delivery systems

Cited by 43 publications

References 59 publications

In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

Activity of Chlorhexidine Gluconate Loaded at Varying Polyelectrolyte Multilayers against Aggregatibacter Actinomycetemcomitans

Porous polysulfone coatings for enhanced drug delivery

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