Toxic effects of arsenic on semen and hormonal profile and their amelioration with vitamin E in Teddy goat bucks

Abstract

The present environmental study has been planned to investigate the toxic effects of arsenic on reproductive functions of Teddy bucks as well as to examine whether these toxic effects are ameliorated by vitamin E. Sixteen adult Teddy bucks were divided randomly into four equal groups A, B, C and D with following treatment: A (control), B (sodium arsenite 5 mg kg BW day ), C (vit E 200 mg kg BW day + Arsenic 5 mg kg BW day ) and D (vit E 200 mg kg BW day ). This treatment was continued for 84 days. Semen quality parameters were evaluated weekly. Male testosterone, luteinising hormone (LH), follicle-stimulating hormone (FSH) and cortisol levels were measured through enzyme-linked immunosorbent assay (ELISA) after every 2 weeks. The data were subjected to two-way analysis of variance followed by Duncan test for multiple comparisons. Semen evaluation parameters were reduced significantly (P < 0.05) in arsenic-treated animals. The serum hormonal profile of testosterone, LH and FSH was reduced significantly (P < 0.05) in arsenic group, while the serum level of cortisol was increased. Vitamin E alleviated the toxic effects of arsenic on semen and hormonal parameters. It may be concluded from this study that sodium arsenite causes major toxicity changes in semen and hormonal profile in Teddy goat bucks and vitamin E has ameliorative effects on these toxic changes.

Correlation of biochemical constituents of seminal plasma with semen quality in Teddy goat (Capra hircus) bucks

“…The results indicated an average semen volume 1.19 ± 0.03 ml. The results of our study are in well agreement with previous findings Zubair, Ahmad, Gul, and Ali () and Okere et al. ().…”

“…These findings were similar with Bitto and Egbunike () while Zubair et al. () reported the higher values. The morphological abnormal spermatozoa in the present study were 6.05% ± 0.29% which were similar with the Catunda et al.…”

“…Individual motility percentage in the present study was 89.18 ± 0.37. These findings are in close harmony with Zubair, Ahmad, Jamil, and Deeba () and Farshad, Yousefi, Moghaddam, and Khalili (). However, motility percentage found in this study was lower than the reported values (96.35% ± 0.9%) of Oliveira et al.…”

Toxicity in Goats Exposed to Arsenic in the Region Lagunera, Northern Mexico

“…Moreover, products manufactured from goat and sheep milk, such as yogurt, have be shown to contain metals such as arsenic [37]. In another context, arsenic has been shown to have a genotoxic and immunotoxic effect on goats [38], while effects have also been found on Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) concentrations and sperm quality in Teddy goats exposed to sodium arsenite [39]. In this sense, by means of the consumption of water with high concentrations of arsenic, environmental contamination is a significant problem for animal health and, consequently, for human health via its transmission up the food chain.…”

Heavy Metal Toxicosis and Male Fertility: The Role of Pentahydroxyflavone Quercetin: a Review

“…Animal and In-Vitro Studies; Sudha, (2012), reported that As caused the reduction in antioxidant enzymes by increasing oxidative stress, and this was corroborated by the damages of the sperm DNA and instability in nuclear constituents (Rajesh et al, 2002). The administration of 5 mg sodium arsenite/kg body weight for 12 weeks to Teddy buck goat caused a significant reduction in sperm count, motility, and male reproductive hormones (Zubair et al, 2016). Male rats exposed to sodium arsenite at 5 mg/L for 4 weeks in drinking water also resulted in decreased testicular weights, accessory sex organ weights, and epididymal sperm counts, as well as extensive degeneration of a wide variety of germ cells at stage VII of the spermatogenic cycle (Jana et al, 2006).…”