Toxic effects of oral administration of extracts of dried calyx of <i>Hibiscus sabdariffa</i> Linn. (Malvaceae)

Fakeye, Titilayo O.; Pal, Anirban; Bawankule, Dnyaneshwar Umrao; Yadav, N. P.; Khanuja, S. P. S.

doi:10.1002/ptr.2644

Cited by 55 publications

(40 citation statements)

References 22 publications

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“…kematian pada mencit (Reanmongkol and Itharat, 2007). Akan tetapi, hal ini berbeda dengan penelitian (Fakeye et al, 2009) …”

Section: Pendahuluanunclassified

Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Liem

Levita²

2017

JFG

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Liver cirrhosis has become a health problem in the world that caused mortality significantly. Treatment used herbs from various countries has been widely applied, one of them by consuming roselle (Hibiscus sabdariffa) calyx extract. This review will be discusse about the usage of H.sabdariffa calyx extract as hepatoprotectorwhich can inhibit the increasing of clinical parameters, such as ALT, AST, ALP, and LDH in various inducer, ie acetaminophen, CCl4, CdCl2, DNPH, and TAA. Its mechanism of action are as an antioxidant, inhibition of cytochrome enzyme, increase liver cell viability percentage, increase CAT, GSH and decrease protein expression of pJNK, tBid and Bax. Although, the consumption of H. Sabdariffa calyx extract may also cause acute, subchronic, and chronic toxicity depend on the dose.

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“…kematian pada mencit (Reanmongkol and Itharat, 2007). Akan tetapi, hal ini berbeda dengan penelitian (Fakeye et al, 2009) …”

Section: Pendahuluanunclassified

Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Liem

Levita²

2017

JFG

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“…These flavonoid substances are effective free radicals scavenger [16]. Anthocyanin found in the extract ethanol is less than one using water [12] hence the increase of Scr is not found to be significant in this research. If muscular dystrophy occurs, the creatinine production will diminish due to muscle formation inefficiency leading to increase in creatinine in the blood [17].…”

Section: Scr and Clcr Measurementsmentioning

confidence: 60%

“…Toxic effect occurs at 10,000-66,000 mg/kg body weight H. sabdariffa intake for rats (regular and long period intake). The effects could be muscular dystrophy leading to renal disturbance [12]. The increase in Scr level is due to the content of anthocyanin and quersetin found in H. sabdariffa extract.…”

Section: Scr and Clcr Measurementsmentioning

confidence: 99%

“…Calyx capsul-ethanol extract H. sabdariffa is safe for rats with an impact of an increase in Scr depending on the dosage [12]. The impact is found to be toxic for rats once they are given 10,000-66,000 mg/kg body weight of H. sabdariffa capsule regularly for a long period [13] also discovers that of H. sabdariffa capsule with a dosage of 50,100 dan 200 mg/kg body weight is safe and effective to reduce free radical on rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of calyx capsule-ethanol extract Hibiscus sabdariffa L. on renal function of healthy volunteers

Harun

Darmawan

Nurani

2017

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Hibiscus sabdariffa contains flavonoid, triterpenoid, anthocyanin which function as immunostimulant. H. sabdariffa is considered safe for animal renal; nonetheless, there are known side effects of which need to be further investigated for human renal. This research aims to investigate the effect of calyx capsule-ethanol extract H. sabdariffa for renal function of healthy male and female for 30 days period by monitoring Scr and Clcr component in their blood samples. The method of this experimental research was by pre and post-treatment by involving 20 healthy volunteers who have met inclusion and exclusion criteria. The volunteers have completed the informed consent for this experiment. Furthermore, volunteers were divided into two groups (10 male and 10 female). Each group was given orally 500 mg of calyx capsule-ethanol extract H. sabdariffa per day for 30 days period. Blood tests were taken on day 0, day 30 after consuming the capsule and day 45 (15 days after the last day of capsule intake) in order to measure the Scr and Clcr concentration in the blood samples by using Jaffe dan Cockcroft-Gault method. The results of each sampling day were further analyzed statistically and compared using Repeated ANOVA dan Friedman test. The results suggest that there was a difference in the renal function on day 0, 30 and 45 samplings. However, there was no significant difference in Scr dan Clcr concentrations on female and male volunteers (p>0.05). Specifically, the type of gender affects Scr concentration (p<0.05); however, it does not affect Clcr concentration (p>0.05). In addition, age and Body Mass Index (BMI) does not affect Scr and Clcr concentrations (p>0.05). The side effects discovered through the monitoring increased in mixturition and bloatedness. Calyx capsule-ethanol extract H. sabdariffa does not affect on renal function of healthy volunteers.

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“…The subchronic effect (12 weeks) of H. sabdariffa calyx aqueous extract at the doses of 1.15, 2.30, and 4.60 g/kg induced testicular toxicity (Orisakwe et al, 2004). Moreover, a 90-day oral administration in albino rats of water and alcohol extracts of dried calyx of H. sabdariffa at a dose of 2,000 mg/kg caused the death of the animals, preceded by a severe loss in weight accompanied with diarrhoea (Fakeye et al, 2009). Although, H. sabdariffa is long used in traditional medicines, the chronic toxicity study of water extract has never been determined.…”

Section: Introductionmentioning

confidence: 99%

Toxicity studies of the water extract from the calyces of <i>Hibiscus sabdariffa L. in rats

Sireeratawong¹,

Itharat²,

Khonsung³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Acute and chronic toxicities of the water extract from calyces of Hibiscus sabdariffa were studied in male and female rats. After 14 days of a single oral administration of test substance 5,000 mg/kg body weight, measurement of the body and organ weights, necropsy and health monitoring were performed. No signs and differences of the weights or behaviour compared to the control rats were observed. The results indicated that the single oral administration of H. sabdariffa extract in the amount of 5,000 mg/kg body weight does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with the extract at the doses of 50, 100, and 200 mg/kg body weight for 270 days. The examinations of signs, animal behaviour and health monitoring showed no defects in the test groups compared to the control groups. Both test and control groups (day 270th) and satellite group (day 298th) were analysed by measuring their final body and organ weights, taking necropsy, and examining haematology, blood clinical chemistry, and microanatomy. Results showed no differences from the control groups. Overall, our study demonstrated that an oral administration of H. sabdariffa extract at the doses of 50, 100 and 200 mg/kg body weight for 270 days does not cause chronic toxicity in rat.

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Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae)

Cited by 55 publications

References 22 publications

Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Effect of calyx capsule-ethanol extract Hibiscus sabdariffa L. on renal function of healthy volunteers

Toxicity studies of the water extract from the calyces of <i>Hibiscus sabdariffa L. in rats

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