Toxicity of Monosodium Glutamate on Male Rat Reproductive System and Effect of Curcumin and Propolis Co-Administeration

Abstract

The safety of monosodium glutamate (MSG) usage has generated much controversy locally and globally. MSG is known to affect the structure and function of male reproductive system as well as fertility. The aim of the present work was to study the toxic effect of MSG on reproductive system of adult male albino rats and to determine the possibility to reverse this effect using curcumin and propolis. Seventy sexually mature male albino rats were used for this study and divided into 7 groups. The first 3 were control groups administered (distelled water, curcumin, and propolis), the 4th group was the experimental and administered MSG at a dose of 4 g/kg body weight for 6ws, the 5 th and 6 th groups, MSG was co-administered with curcumin or propolis at the doses of 10 mg, and 50 mg/kg body weight respectively and the 7 th group received combination of MSG, curcumin and propolis. It was found that MSG has adverse impacts on male rat reproduction including decrease testicular weight, with histological structure alternation, decrease sperm count and plasma level of testosterone and luteinizing hormone (LH). Coadministration of curcumin and propolis either separately or combined ameliorate these effects where testicular weight and structure of seminiferous tubules with their lumens full of sperms were regained compared to MSG treated animals. Sperm count; testosterone and LH levels were improved.

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

“…In the present study, pregnant females in the different experimental treated groups showed a significant increase in body weight gain during the gestation period. This result agrees with Tala’a ( 2019 ), Mohamed et al ( 2017 ), and Savcheniuk et al ( 2014 ). Moreover, Abd El-Aziz et al ( 2014 ) found prolonged administration of MSG causes an initial increase in weight gain followed by terminal suppression and independent of food consumption.…”

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

“…Dosing of heavy metals mixture produced lower level of glutathione peroxidase (GPx) in liver (p < 0.0001) and kidney (p < 0.001) tissues at heavy metals group in comparison with control group, this could probably due to the utilization of its defense mechanism against toxic metals within these organs as a result of ROS generation; such suggestion is matched with Ercal et al, (2001); Saxena et al, (2005) and Bas & Kalender (2016). However, rats that exposed to toxic metals and treated with propolis exhibited signi cant improving in the activities of GPx in livers (p < 0.001) as well kidney (p < 0.01) when compared with heavy metals group; that issue clarify the protective role of propolis in recovering the affected tissues of liver and kidney as healthy rats through reducing combined toxicity of investigated metals; these ndings were corroborated very well with Salama & El-Bahr, (2007);Bhadauria, (2012) and Mohamed et al, (2017). Additionally, after propolis treatment, both livers and kidneys of rats exhibited statistical improving (p < 0.0001 and p < 0.01, respectively) in the activities of glutathione reductase (GR) which previously showed signi cant decrease among the livers (p < 0.0001) and kidneys (p < 0.001) of rats at heavy metals group comparing to control, this may attributed to the ability of investigated metals to overcome the vital role of GR in order to interfere with the disul de bond of glutathione enzyme and inhibits its activity therefore, prevent the optimal balance and make cells more susceptible to oxidative damage; our observations are in the same way of those obtained by; Ercal et al, (2001) and Jomova & Valko, (2011).…”

Emulgels Containing Propolis and Curcumin: The Effect of Type of Vegetable Oil, Poly(Acrylic Acid) and Bioactive Agent on Physicochemical Stability, Mechanical and Rheological Properties

“…The use of multiple antioxidant and healing chemotherapeutic agents can favor the treatment of skin lesions. Recent studies have shown the synergistic effects of propolis extract (PRP) and curcumin (CUR) increasing the therapeutic efficiency, mainly due to their antioxidant, anti-inflammatory and antimicrobial activities [34,35]. The PRP is a complex mixture of vegetable substances used to protect the comb by sealing gaps and keeping insects and microorganisms away [36,37].…”