Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae)

Awodele, Olufunsho; Oreagba, Ibrahim Adekunle; Odoma, Saidi; Silva, Jaime A. Teixeira da; Osunkalu, Vincent Oluseye

doi:10.1016/j.jep.2011.10.008

Cited by 162 publications

(141 citation statements)

References 25 publications

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“…The leaves of moringa are also reported to be a rich source of α and γ-tocopherol (Sánchez-Machado et al 2006). Results of all four antioxidant assays and earlier reports on nutritional and anti-nutritional properties reported by Awodele et al (2012) give positive references for introducing moringa leaves in human diet. Pearson correlation coefficient Non-significant correlation was observed between extract values (except for moringa) of TPC-PCL and TPC-ABTS (Table 6).…”

Section: Antioxidant Activitiesmentioning

confidence: 60%

Comparison of Measurements of Antioxidant Activity in the Selected Leafy Vegetables Depending on Extraction Solvent

Jaiswal

Patel

Saxena

et al. 2017

Journal of Horticultural Research

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Four leafy vegetable species, spinach (Spinacia oleracea), amaranthus (Amaranthus viridis), fenugreek (Trigonella foenum-graecum) and bathua (Chenopodium album), were extracted with three different solvents (80% ethanol, 80% acetone and water) for maximum recovery of phenol and antioxidant compounds in the extract. The results of extraction were compared with extraction from moringa (Moringa oleifera) leaves that is known as a very rich source of antioxidants. The study showed that, it is very difficult to justify a single solvent for extraction of antioxidant compounds from different plants. Results from different solvents used for extracting the bioactive compounds mostly depend on the type of compound extracted (polar/medium polar/non-polar) present in leafy matrices. Here, 80% acetone extract showed highest total phenol content in moringa leaves but the overall antioxidant activity in the leaves of four vegetables was observed to be better after extraction with 80% ethanol. Nevertheless, in most assays, independent of solvent used for extraction, the moringa leaves were the richest source of polyphenols and antioxidants.

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Section: Antioxidant Activitiesmentioning

confidence: 60%

Comparison of Measurements of Antioxidant Activity in the Selected Leafy Vegetables Depending on Extraction Solvent

Jaiswal

Patel

Saxena

et al. 2017

Journal of Horticultural Research

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“…Previous studies by Amaglo et al [3], Limon-Pacheco and Gonsebatt [19], and Mahajan and Mehta [20] have reported the pharmacological, antioxidant, and anti-inflammatory property of M. oleifera respectively. Furthermore, Awodele et al, [4] worked on the toxicological evaluation of the aqueous extract of Moringa oleifera Lam (Moringaceae). Oyedepo et al, [26] evaluated the anti-hyperlipidemic effect of aqueous leaves extract of Moringa oleifera while Gupta et al, [15] worked on the evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes.…”

Section: Introductionmentioning

confidence: 99%

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Denen¹,

Eze²,

Adams³

et al. 2014

IJNFS

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Abstract:The hypolipidaemic effect of ethanol leaf extract of Moringa oleifera in experimentally induced hypercholesterolemic rats was investigated. Thirty six (36) wistar rats of both sexes weighing 130.53±4.86 were used for the study. The animals were completely randomized into six groups (A-F) comprising 6 animals each. Groups A, B and C comprise female rats administered 1 ml of distilled water, high dose of 600 mg/kg and low dose of 300 mg/kg body weight of the extract respectively. Groups D, E and F comprise male rats administered 1 ml of distilled water, high dose of 600 mg/kg and low dose of 300 mg/kg body weight of the extract respectively. Hypercholesterolemia was induced by feeding the animals with high fat diet for 21 days before administration of the extract. After the 21 days of feeding, administration of extract lasted for 14 days. Preliminary phytochemical screening revealed that the ethanol leaf extract of M. oleifera contains alkaloids, tannins, carbohydrates and cardiac glycosides. Only the high dose female group (600 mg/kg body weight) lost or maintained their body weight significantly (p<0.05), the rest did not. Body weight was not significantly (p>0.05) altered in the male group administered low dose and high dose, showing that the dose of the extract slightly affected their weight. For serum lipids, serum total cholesterol concentration in both male and female reduced significantly (p<0.05), both in those given low and high doses of the extract. Serum high density lipoprotein cholesterol (HDLC) level significantly (p<0.05) increased both in male and female rats that were administered high dose of 600 mg/kg body weight of the extract, but was not significantly (p>0.05) affected in other groups. Serum low density lipoprotein cholesterol (LDLC) level also reduced significantly (p<0.05) in both male and female rats that were administered high dose of the extract, but was not significantly (p>0.05) altered for those that received low doses (300 mg/kg body weight) of the extract. There was no significant (p>0.05) reduction in the LDLC of the male rats. Serum triacylglycerol (TAG) concentration in male and female rats reduced significantly (p<0.05), in those that received low and high doses of the extract. Overall, findings from the present study suggest that the ethanol leaf extract of M. oleifera has hypolipidaemic effect. Therefore, the leafy vegetable may be recommended to patients that have problems with high serum lipid profiles and also for people that want to lose or maintain body weight.

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“…In an acute oral toxicity study by [16], Moringa Oleifera leaf extract was documented to be non-lethal in animals at 6400 mg/kg body weight. In addition, [17] found that Moringa Oleifera leaf extract was documented to be non-lethal in animals at 2000 mg/kg body weight.…”

Section: Discussionmentioning

confidence: 99%

Anti-coccidial Activity of Moringa Oleifera Plant

A.¹

2016

AVS

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Abstract:Moringa Oleifera leaves were screened for its toxicological effect and some pharmacological activities in broiler chicken. Toxicological effect was studied using upgrading oral doses of 75% ethanolic extract in different groups of mice with monitoring the toxicological symptoms and mortality rate. The anti-coccidal activity of Moringa Oleifera powdered leaves for prevention and its 75% ethanolic extract for treatment of coccidiosis were studied in broilers. The obtained result proved that there were no toxicological symptoms or mortalities obtained till oral administration of 6000 mg/kg b. wt. Inclusion of Moringa olifera powder (0.5 and 1%) to broiler's feed were very efficacious and equal to diclazuril (1ppm) in preventing symptoms of coccidiosis associated with experimental infection with mixed Eimeria species. The anti-coccidal activity of Moringa Oleifera powdered leaves and its 75% ethanolic extract were studied on one-day old chicks. The experimental infected chicks with mixed Eimeria species induced severe coccidiosis in non medicated chicks and led to high mortality reached to (26.76%). Addition of 200 and 400ppm of Moringa Oleifera ethanolic extract induced marked curative effect of cocci diosis manifested by reduced mortality percent and improved PM lesion to be 13.3 and 10% respectively compared to 13.3% for group treated with the reference drug (25ppm) toltrazuril.

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Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae)

Cited by 162 publications

References 25 publications

Comparison of Measurements of Antioxidant Activity in the Selected Leafy Vegetables Depending on Extraction Solvent

Comparison of Measurements of Antioxidant Activity in the Selected Leafy Vegetables Depending on Extraction Solvent

Hypolipidaemic Effect of Ethanol Leaf Extract of Moringa Oleifera Lam. in Experimentally induced Hypercholesterolemic Wistar Rats

Anti-coccidial Activity of Moringa Oleifera Plant

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