Toxicology and free radicals scavenging property of Tamra bhasma

Pattanaik, N.; Singh, Ajit; Pandey, Ravi Shankar; Singh, B. S.; Kumar, Manoj; Dixit, S. K.; Tripathi, Yamini B.

doi:10.1007/bf02867385

Cited by 32 publications

(18 citation statements)

References 5 publications

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“…It was also proved that Tamra Bhasma inhibits lipids peroxidation (LPO), prevents the rate of aerial oxidation of reduced glutathione (GSH) content and induces the activity of superoxide dismutase (SOD) 5 . Moreover all the herbal drugs present in the Tamra yoga have been proved for their antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Tamra Bhasma and Tamra Yoga: An in Vitro Evaluation

K¹,

Sridurga²,

Subbaiah³

2018

Int. J. Res. Ayurveda Pharm.

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The main objective of the present study is to investigate the antioxidant activity of Tamra Bhasma and Tamra Yoga. 2,2 -Diphenyl-1-Picrylhydrazyl (DPPH) scavenging assay has been used in the determination of In Vitro antioxidant activity. Increasing order of Percentage of Inhibition was seen in 100 µl, 200 µl, 300 µl, 400 µl and 500 µl sample concentrations in both Tamra Bhasma and Tamra Yoga. Tamra Bhasma showed 58.67% of inhibition and Tamra Yoga showed 55.47% of inhibition in 500 µl sample concentrations respectively. The present study revealed that both the Tamra Bhasma and Tamra yoga showed good antioxidant activity. Tamra Bhasma showed relatively higher antioxidant activity when compared to Tamra Yoga.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Tamra Bhasma and Tamra Yoga: An in Vitro Evaluation

K¹,

Sridurga²,

Subbaiah³

2018

Int. J. Res. Ayurveda Pharm.

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“…The animals of above experiment were sacrificed on 30th day blood was collected for hematology and biochemical study (renal function test and liver function tests). Their thymus and spleen were collected, dried with blotting paper and weighted 19. Their femur was collected from both legs and bone‐marrow cells were saved in RPMI 1640 media with 10% serum and counted with Trypan Blue exclusion method.…”

Section: Methodsmentioning

confidence: 99%

Immunomodulation property of hexane fraction of leaves of Cinnamomum tamala Linn. in rats

Chaurasia

Mishra

Tripathi

2010

Cell Biochemistry & Function

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The leaves of Cinnamomum tamala Linn. (CT) (Lauraceae) clinically used in Ayurveda as antidiabetic and diuretic, but no reports are available towards immunomodulating property. Its hexane fraction (CTH) was orally given to rats for 10 days and delayed type of hypersensitivity (DTH), antibody production against sheep red blood cells (SRBCs), mitotic index in bone marrow cells and concanavalin A (Con A) mediated proliferation of lymphocytes were assessed. Further on 30 days treatment, change in body weight (BW), spleen weight, thymus weight, bone marrow cellularity and hematological changes were observed. It inhibited significantly the DTH response (IC(50) 1475 +/- 57.19 mg kg(-1) BW), antibody production, suppressed mitotic index in bone marrow cells along with the suppression of lymphocyte proliferation against Con A (IC(50) 63.33 +/- 1.95 microg mL(-1)). In all experiments, cyclophasphamide and dexamethasone had been used as reference drug for in vivo and in vitro studies, respectively. On 30 days treatment, the CTH (800 mg kg(-1) BW and above) significantly suppressed growth rate, increase of spleen and thymus weight and low bone marrow cellularity. In hematological examination, it inhibited total white blood cell and lymphocytes count and increased per cent of polymorphs. Thus, it could be suggested that the fraction possesses immunosuppressive property at doses, higher than 800 mg kg(-1) BW in rats.

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“…Tamra vshma (roasted copper) has hepatoprotective activity (Tripathi and Singh, 1996). Pharmacological investigations have reported the use of tamra bhasma for treating gastric ulcers and secretion, the management of lipid peroxidation in the liver of albino rats and as an antioxidant (Tripathi and Singh, 1996;Sanyal et al, 1982;Pattanaik et al, 2003). Abhra bhasma (mica/siliceous encrustation) was believed to be a rejuvenator and increase vitality; where gandhaka (sulphur) has some anti-inflammatory and immuno-stimulant activities (Dayrens et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Toxicological Studies of “Chondrokola rosh”, an Ayurvedic Preparation on Liver Function Tests of Rats

Nasrin¹,

Bachar²,

Choudhuri³

2011

Afr. J. Trad. Compl. Alt. Med.

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Chondrokola Rosh (CKR) is a traditional metallic Ayurvedic preparation widely used by the rural and ethnic people of Bangladesh in dysuria. It is a preparation of various roasted metals (Hg and Cu), non-metal (sulphur and Mica) and medicinal herbs. Considering the controversy over the risk of toxic heavy metals in Ayurvedic herbo-mineral preparations, toxicological parameters on liver functions were investigated. A single dose of 100mg/kg body weight of the preparation was administered orally to the rats of both sexes for ninety days. In this evaluation a statistically significant (p<0.001) increase of serum albumin levels in male (17%) and female (15%) rat groups were observed. On the other hand, the plasma bilirubin level was decreased 50% and 28% respectively in both rats groups. But no remarkable differences were observed in plasma protein, sGPT, sGOT and ALP activities from their corresponding control values. This study showed that CKR had no remarkable toxic effect on liver of the animals despite the presence of traces of transformed heavy metals.

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Toxicology and free radicals scavenging property of Tamra bhasma

Cited by 32 publications

References 5 publications

Antioxidant Activity of Tamra Bhasma and Tamra Yoga: An in Vitro Evaluation

Antioxidant Activity of Tamra Bhasma and Tamra Yoga: An in Vitro Evaluation

Immunomodulation property of hexane fraction of leaves of Cinnamomum tamala Linn. in rats

Toxicological Studies of “Chondrokola rosh”, an Ayurvedic Preparation on Liver Function Tests of Rats

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