During general anesthesia a large number of surgeries such as pilonidal sinus excision are conducted in prone position. The main purpose of this research is the application of laryngeal mask airway in prone position in pilonidal cyst excision after Atracurium injection. A doubleblind descriptive experiment was performed on 85 patients (ASA I-II), such that they reclined on the operating table in prone position. After preoxygenation, general anesthesia was induced by Midazolam, Fentanyl, Propofol, and Atracurium. At the same position, the laryngeal mask airway was placed. Heart rate, systolic and diastolic blood pressure was reduced significantly after anesthesia. Laryngeal mask airway insertion was successful in 78 patients on first try. Induction/incision time was reduced. Laryngospasm and pulmonary aspiration was not observed and rate of sore throat was 16/85 patients. Based on our data, it seems that for minor surgeries in prone position, laryngeal mask airway is applicable after the administration of muscle relaxant, although further studies are required.