Traditional antidiabetic plants from Indonesia

Hartanti, Dwi; Budipramana, Krisyanti

doi:10.32859/era.19.34.1-24

Cited by 7 publications

(11 citation statements)

References 37 publications

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“…The decrease in blood glucose levels in intervention group was caused by presence of bioactive compounds contained in extract of red betel leaf including flavonoid, alkaloid, tannin, and saponin, while bitter herb extracts contained andrographolid, flavonoid, saponin, phenolic total, and anthraquinone. 21,22,23 As antidiabetic agent, flavonoid and alkaloid are able to regenerate damaged pancreatic beta cells. 8 Red betel leaf extract could reduce blood glucose level in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Total and HOMA-IR of Diabetic Rats Given Crocatum piper and Andrographis paniculata Leaf Extracts

Rahmawati

Afifah

2021

J. Biomed. Transl. Res.

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Background: Type-2 diabetes mellitus (T2DM) is a silent killer which the prevalence continues to increase in every year. Increased oxidative stress occurs in T2DM. Red betel and bitter herb leaf extracts (RBBH) contain a lot of antioxidants. This combination is expected to provide better safety than if used singly because the content of andrographolid in bitter herb has effect such as nausea, vomiting, loss of appetite, and antifertility if consumed in high doses.Objective: The study aimed to prove the effect of red betel and bitter herb leaf extracts on antioxidant total and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in T2DM rats given high-fat diet and Streptozotocin (STZ) induction.Methods: Experimental randomized study with pre-post-test control group design using 25 Sprague Dawley male rats. T2DM model was conducted by providing high-fat feed for 14 days and induction of Streptozotocin-Nicotinamide, then given a combination of red betel and bitter herb leaf extracts at doses of 237.5 mg/kg BW, 225 mg/kg BW, and 212.5 mg/kg BW for 21 days. The measurement of antioxidant total used 2,2-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) method. HOMA-IR measured by ELISA (Enzyme-linked immunosorbent assay) method using insulin level equation and fasting blood glucose level measured by glucose oxidase-peroxidase aminoantrypirin (GOD-PAP). Data analysis used paired t-test, wilcoxon test, and ANOVA test to analyze differences in antioxidant total and HOMA-IR value among groups and followed by Bonferroni post-hoc test.Results: All treatments could reduce HOMA-IR and significantly increase antioxidant total (p<0.05). The most decrease in HOMA-IR and increase in antioxidant total at dose 237.5 mg/kg BW of red betel and bitter herb leaf extracts.Conclusion: The combination of red betel and bitter herb leaf extracts with dose 237.5 mg/kg BW, 225 mg/kg BW, and 212.5 mg/kg BW can improve blood glucose, insulin, and HOMA-IR levels in type-2 diabetes mellitus rats.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Total and HOMA-IR of Diabetic Rats Given Crocatum piper and Andrographis paniculata Leaf Extracts

Rahmawati

Afifah

2021

J. Biomed. Transl. Res.

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“…crispa has also been used for a long time in particularly Indonesian and Malaysian folk medicine as an ingredient of popular jamus for lowering elevated blood sugar levels [149]. As a result, some products prepared from the leaf of the plant have recently entered the health-food market as antidiabetic nutraceuticals in the form of sachets containing the raw crude powder (fermented and unfermented) for preparing a tea, as an additive in coffee, or as capsules for oral intake [150]. So far, no clinical data are available on the safety and side effects of the long-term use of these products, but several pharmacological studies reported that they do not exert acute toxicity [151,152].…”

Section: Acanthaceae: Strobilanthes Crispa (L) Blumementioning

confidence: 99%

“…Like Indonesians and other peoples from south-eastern Asian countries, Surinamese-Javanese use tea from S. crispa leaves (alone or together with those from certain other plants) to lower elevated blood sugar levels [51]. This traditional use is supported by the blood-glucose-lowering effects of hot water extracts of fermented and/or unfermented leaf in both normal and streptozotocin-induced diabetic rats [150]. Both preparations also improved lipid profile (total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol) in the animals [150].…”

Section: Acanthaceae: Strobilanthes Crispa (L) Blumementioning

confidence: 99%

“…This traditional use is supported by the blood-glucose-lowering effects of hot water extracts of fermented and/or unfermented leaf in both normal and streptozotocin-induced diabetic rats [150]. Both preparations also improved lipid profile (total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol) in the animals [150]. S. crispa leaf juice given together with a basic diet to streptozotocin-induced diabetic and normal rats produced comparable results, along with significantly increased glutathione peroxidase and superoxide dismutase activities in both groups of animals [153].…”

Section: Acanthaceae: Strobilanthes Crispa (L) Blumementioning

confidence: 99%

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Hypoglycemic Activity of Plant-Derived Traditional Preparations Associated with Surinamese from African, Hindustani, Javanese, and Chinese Origin: Potential Efficacy in the Management of Diabetes Mellitus

Mans¹

2022

Basics of Hypoglycemia

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Diabetes represents one of the most frequent causes of morbidity and mortality in the world. Despite the availability of a wide range of efficacious forms of treatment, many patients use traditional (plant-derived) preparations for treating their disease. The Republic of Suriname (South America) has a relatively high prevalence of diabetes. Due to its colonial history, the Surinamese population comprises descendants of all continents, the largest groups being those from enslaved Africans and from indentured laborers from India (called Hindustanis), Indonesia (called Javanese), as well as China. All these groups have preserved their cultural customs including their ethnopharmacological traditions, and are inclined to treat their diseases with plant-based preparations, either alone or together with allopathic medications. This chapter opens with some generalities about diabetes; subsequently provides some information about the history, worldwide epidemiology, diagnosis, types, and treatment of this disorder; then focuses on Suriname, giving some information about its geography, demographics, and economy, as well as the epidemiology of diabetes in the country; then extensively evaluates eight blood-glucose-lowering plants that are mainly associated with the four largest ethnic groups in Suriname by reviewing phytochemical, mechanistic, preclinical, and clinical literature data; and concludes with a consideration of the potential clinical usefulness of the plants against diabetes.

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“…Diabetes mellitus is a metabolic disorder disease that occurs chronically and is caused by many factors with characteristics of high blood sugar levels. Hyperglycemia and hyperlipidemia are one of the main characteristics of diabetes mellitus, which can trigger complications (Hartanti & Budipramana, 2020;Pappachan et al, 2019;Salehi et al, 2019). Therefore, efforts to control blood sugar levels are the primary goal to delay the development of complications in patients with diabetes mellitus (Sun et al, 2021;Febrinasari et al, 2020;Maruhashi & Higashi, 2021).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats

Sanik¹,

Yuliawati²,

Rahman³

et al. 2022

Pharmaciana

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Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0 th , 7 th , 10 th , and 14 th . Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14 th day. Results were analyzed by one-way ANOVA test. The followed by Duncan's test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.

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Traditional antidiabetic plants from Indonesia

Cited by 7 publications

References 37 publications

Antioxidant Total and HOMA-IR of Diabetic Rats Given Crocatum piper and Andrographis paniculata Leaf Extracts

Antioxidant Total and HOMA-IR of Diabetic Rats Given Crocatum piper and Andrographis paniculata Leaf Extracts

Hypoglycemic Activity of Plant-Derived Traditional Preparations Associated with Surinamese from African, Hindustani, Javanese, and Chinese Origin: Potential Efficacy in the Management of Diabetes Mellitus

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats

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