2015
DOI: 10.1016/j.fitote.2015.07.014
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Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?

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Cited by 22 publications
(20 citation statements)
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“…Aus phytochemischer Sicht ist die Droge Maisgriffel durch das Vorkommen von Flavonoiden, Tanninen, Phytosterolen, Chlorogensäure, Allantoin, Vitaminen, Mineralien, Kohlenhydraten und etwas ätherischem Öl gekennzeichnet [15][16][17][18][19]. Das Vorliegen ungewöhnlicher Flavonglykoside, wie etwa Maysin und seinen Derivaten wurde beschrieben [20].…”
Section: Inhaltsstoffeunclassified
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“…Aus phytochemischer Sicht ist die Droge Maisgriffel durch das Vorkommen von Flavonoiden, Tanninen, Phytosterolen, Chlorogensäure, Allantoin, Vitaminen, Mineralien, Kohlenhydraten und etwas ätherischem Öl gekennzeichnet [15][16][17][18][19]. Das Vorliegen ungewöhnlicher Flavonglykoside, wie etwa Maysin und seinen Derivaten wurde beschrieben [20].…”
Section: Inhaltsstoffeunclassified
“…Die Kontamination der Droge mit dem Biozid Benzethoniumchlorid wurde eben-falls kürzlich beschrieben und impliziert die Notwendigkeit des umfänglichen Einsatzes geeigneter Qualitätskontrollen auf Ebene des Drogenhandels (was aber in Deutschland -wie Untersuchungen zeigten -nur in beschränktem Ausmaß durchgeführt wird) [20].…”
Section: Inhaltsstoffeunclassified
“…Despite its wide spread use, there have been no reports which demonstrate its biological activities. Recently, it has been reported that corn possesses antiadhesive activity against uropathogenic E. coli [10], as well as antioxidant and antimutagenic activities [11]. In addition, no studies have examined the effects of Z. mays on inflammation-associated gene expression.…”
Section: Introductionmentioning
confidence: 99%
“…66 Preclinical in vivo data or clinical studies on positive effects of celery seed extracts for UTI 67 have not been published until now, but reports on potential antimicrobial effects under in vitro 68 conditions are available (Zhou et al, 2009;Shanmugapriya and Ushadevis 2014). Within the 69 last years investigations of new drug candidates with antiadhesive properties against 70 uropathogenic E. coli (UPEC) have been described, indicating that the blocking of bacterial 71 outer membrane adhesins (especially FimH) effectively prevents infection of eukaryotic host 72 cells by the pathogen (Beydokthi et al, 2017a;Beydokthi et al, 2017b;Rafsanjany et al, 2015a, 73 Rafsanjany et al, 2015b, Kleeb et al, 2016 (Hacker and Ott, 1986) were used in this study. Bacteria from the second passage were used for 118 all tests and cultivated from frozen stocks.…”
mentioning
confidence: 99%
“…The antiadhesive effect of CSE was additionally confirmed by a flow cytometric assay using 298 UPEC strains NU14 and UTI89. In principle FITC-labeled bacteria were coincubated with CSE 299 and T24 bladder cells for 2 h, non-adherent bacteria are washed off from the cell monolayer 300 which was subsequently trypsinzed and the fluorescence intensity of the individual cells was 301 determined by flow cytometry (Rafsanjany et al, 2015a;Rafsanjany et al, 2015b). As shown 302 in Fig.…”
mentioning
confidence: 99%